Drug induced agranulocytosis is encountered in patients on anti-thyroid medications, ranging from mild forms to life threatening situations. Expeditious discontinuation of the offending drugs helps to resolve agranulocytosis. Various parametric values are evaluated to monitor the side effects of Carbimazole. One main parameter includes the evaluation of TLC (Total Leukocyte Count). In this case report we are going to emphasize carbimazole induced agranulocytosis. Clinicians should be extremely conscious about such events and complete blood count monitoring helps to circumvent such situations.