Toxic epidermal necrolysis (TEN) is a rare, and life-threatening condition that affects people of all ages, causing peeling and blistering of skin over the body. The main cause for Toxic epidermal necrolysis is drugs, which can also be triggered by infections and malignancy. Also, the genetic background of the patient, the coexistence of cancer, or concomitant radiotherapy can have an impact on the incidence of SJS(Steven Johnson syndrome ) and TEN. Fluconazole is an antifungal medication indicated and belongs to the azole class of drugs, which work by reducing ergosterol synthesis by inhibiting the fungal cytochrome P450 enzyme. After taking the tablet fluconazole 150mg for 5 days a 40-year-old male patient presented with complaints of discharge from eyes & redness for 5 days, Asymptomatic red lesions all over the body for 5 days, painful lesions in the oral cavity for 3 days, Pins and needle sensation over both feet increased while walking, and fever for 1 day. When the patient admitting to TEN, the most important thing is to analyze the patient's past medical history and medication history. The patch test confirmed that the patient has an allergic reaction to T. Fluconazole, hence it was discontinued. Through effective systemic and topical therapy, the patient's condition is improved, also the weekly checkup will be helpful for further monitoring.