Abstract
Treating central nervous system diseases is very challenging because of the
presence of a variety of formidable obstacles that obstruct drug delivery.
The brain is very complicated as well as fragile organ and Nature has been
played a very efficient role to protect it. The brain is protected from many
toxic substances and various chemicals by the presence of two barriers
namely blood brain barrier (BBB) and blood cerebrospinal fluid barrier
(BCSFB). Various routes of drug targeting to the brain now become an
important tool in the pharmaceutical field because of many complicated
disease of the brain like Alzheimer, Huntington disease, epilepsy etc.
Therefore various routes like craniotomy, osmotic disruption, colloidal drug
delivery, intranasal route of administration and nanotechnology have been
proposed to favors brain drug delivery. Novel drug delivery is the decisive
part of this review. This review includes general methods that can enhance
drug delivery to the brain and discussed the appropriate route by which such
a drug delivery can be possible.
