Abstract
Inflammation is the response to injury of cells and body tissues through different factors such as infections, chemicals, and thermal and mechanical process. COX-1 and COX-2 isoforms contribute to mucosal defense. Selective COX-2 inhibitors elicit less GI damage and bleeding than conventional NSAIDs. The current research focus is to develop less toxic drugs as early as feasible in the disease process. The present study was carried out to investigate the analgesic activity of Rasa Mezhugu (500mg/kg) in 2 % CMC against the standard drug Diclofenac sodium using acetic acid induce writhing in rats to create pain sensation. No other toxic symptoms were observed in any of the dose treated animals. The Writhing method was followed to evaluate the analgesic property of Rasa Mezhugu and the results revealed that it has statistically significant (P<0.01) analgesic activity by relieving painful conditions.
