Abstract
The challenges in Ocular drug delivery system are due to unique anatomy and physiology of eye. The conventional formulations like solutions, suspensions and ointments shows disadvantages such as rapid precorneal elimination, high variability, drainage by gravity and absence of controlled release. So overcome to these problems newer pharmaceutical ophthalmic formulation such as in-situ gel, nanoparticle, liposome, nanosuspension, microemulsion, iontophoresis and ocular inserts have been developed in last three decades increase the bioavailability of the drug as a sustained and controlled manner. Major improvements are required in each of the technologies discussed in this review. This review includes various recent strategies that are developed and under development stage so far.
