Abstract

The present investigation concerns the development of Sustained release
matrix tablets of Captopril, which after oral administration are designed to
prolong the duration up to 12 hrs and thereby increase patient compliance,
reduced frequency of administration and increase therapeutic efficacy. Ten
batches of tablets were fabricated containing Captopril, polymers HPMC
K100M, ethyl cellulose, sodium CMC and other excipients. All the batches
were formulated by direct compression. The evaluation was done on the
granules which include compressibility, flow property. The tablets were
evaluated for appearance, thickness, hardness, assay, weight variation,
friability, and in vitro release studies. The results obtained were satisfactory
and complies with the Pharmacopoeial specifications. The formulation
containing HPMC K100M and ethyl cellulose (F7) showed slower release
as compare to other formulations. The in-vitro release data was treated with
mathematical equations. Thus the combination of HPMC K100M and ethyl
cellulose (1:1) shows satisfactory retarding release of Captopril from matrix
to 12 hrs.