Abstract
Loperamide HCL is an opioid receptor agonist and acts on the muopioid receptors in the myenteric plexus large intestines; it works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. Loperamide HCL is a synthetic antidiarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide HCl, fast dissolving tablets have been prepared by direct compression method by using kneading mixture of Loperamide HCl and Crospovidone, after incorporating superdisintegrants such as Ac-di sol, Sodium starch glycolate, in
different concentrations. All the formulation were evaluated for the influence of disintegrants and their concentrations on the characteristics of fast dissolving tablets mainly in terms of disintegration time and dissolution rate. Tablets containing Ac-di-sol at high concentration showed better disintegration character (10 seconds) along with rapid release (97.3%). The concentration of the superdisintegrants had also an effect on disintegration time and invitro dissolution. The resulting tablets were also evaluated for itshardness, thickness, wetting time and water absorption ratio.
