Abstract
Literature survey of coumarin reviles that coumarin showed various biological and therapeutic applications. Five membered heterocycles like thazolidinones are also important, because it show various applications. Present scheme comprises ofsynthesis of thaizolidinone heterocycles of coumarin. For total synthesis previously prepared1,2,4- triazole derivative of coumarin used as a basic molecule. This triazole derivative treated with choloroacetyl chloride to give chloro-acetyl derivative which on further treatment with KSCN generate thiocynate. Obtained derivative of thiocynate condensed with DMF and then with 2% HCl to yield thiazolidinone. The synthesized compounds have been confirmed by their elemental and spectral techniques. All the synthesized derivatives have been found significant to moderate activity against tested bacterial strains. Results obtained after spectral technique and antimicrobial study proves that we able to synthesize thaizolidinone derivatives of coumarin which also exhibit antimicrobial activity.
