Abstract
A series of novel 2-aminothiazole (1,3,5,7,9) and 2-aminooxazole (2,4,6,8,10) derivatives were synthesized by microwave assisted method as a green chemistry approach and were characterized by spectral methods (UV-visible, IR, and NMR) and elemental analysis. Molecular docking studies for the synthesized compounds were carried out against HPV 16 proteins. Further they were screened for their anticancer activity against HeLa cell lines by MTT assay. Compound 9, 5 and 2 showed marked binding scores in the docking studies and exhibited anticancer activity with an IC50 value of 19.5, 31.20 and 52.43 respectively.
