Abstract

The main goal of present work is to design a colon specific drug delivery of Tramadol hydrochloride multiparticulate systems by using sodium alginate and pectin polymers. Beads are coated with eudragit polymer for achieving colon specific by combining both pH and polymer based drug delivery. Pectin sodium alginate beads were prepared by ionotropic gelation method by using calcium chloride as cross linking agent. Coating is carried out by oil in oil solvent evaporation method. Particle size analysis, entrapment efficiency, scanning electron microscopy studies, swelling studies and Invitro dissolution studies were carried out. The optimized formulation was used for determining the analgesic activity by using eddy’s hot plate technique and tail flicking method. The % drug release was highest for the formulation TCB1 i.e. 93.2% and the controlled release was shown by the formulation TCB9 i.e. 74%. Biological evaluation was carried out and the percentage increase in reaction time was found to be 81.3% for the eddy’s hot plate method and the tail flicking latency time was found to be 93.13% for the optimized formulation (TCB9). It suggests that the optimized formulation showed increased resistance than the standard. The studies had clearly indicated that Tramadol hydrochloride through the pectin sodium alginate beads were very effective to deliver the drug specifically to colon.