Abstract
Mucoadhesive drug delivery systems are delivery systems, which utilized the property of certain polymers. It is the subject of great interest during recent years because it provides the possibility of avoiding either destructing by GIT contents or hepatic first pass inactivation of drug , nearly about 40%of drugs are lipophilic and failed to reach market due to poor water solubility. The lesser bioavailability and first-pass metabolism is the reason for the suitable dosage form development containing Nifedipine. The Pre-formulation study such as, IR-study is carried out by using FT-IR apparatus which shows compatibility between Drug and different polymer. The different formulation of Nifedipine using different polymers were prepared and evaluated based on weight variation, Surface PH, Folding endurance, Drug content, Dissolving time, Disintegration time, Dissolution studies. Results shows satisfactory evaluation parameters including a higher percentage of Drug release .The main advantage of this formulation is that it contain a lower drug dose and by-pass its firs-pass metabolism.
