Bronchial asthma, the most prevalent chronic disease in adults and children, is characterized by airway obstruction and bronchial hyper-responsiveness, presenting symptoms such as difficulty breathing, cough, and rapid pulse. This study aimed to evaluate the anti-asthmatic properties of aethanolic extract of leaves of Gomphrena globosa using isolated goat tracheal preparations. Tracheal rings were exposed to histamine and acetylcholine to induce contractions, with the extract tested for bronchodilator activity. Phytochemical analysis, preliminary tests, DPPH assay, and assessments of phenolic and flavonoid content were performed. The leaves extract significantly inhibited induced contractions, indicating potent anti-asthmatic effects. The study supports the traditional use of these plants in treating asthma and validates the goat tracheal model for bronchodilator screening. These findings suggest potential clinical applications of the extract in asthma management.

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Simran Chaudhari Dr. D.Y. Patil College of Pharmacy, Akurdi (Affiliated to Savitribai Phule Pune University), Pune, Maharashtra, IndiaPlease cite this article in press as Simran Chaudhari et al. In-Vitro Evaluation of Gomphrena Globosa Leaves Extract fo