For the purpose of performing simultaneous determinations of diclofenac sodium and rabeprazole sodium in tablet dosage form, an easy-to-use, cost-effective, accurate, precise and validated diffuse reflectance infrared fourier transform spectroscopy method has been developed. Measurement of the spectral wave number of the infrared band corresponding to the NH₂ group stretch at 3388 cm^-1 for diclofenac sodium and the S=O group at 1274 cm^-1 for rabeprazole sodium is included in the newly developed approach. The approach was found to be linear over the range of 1%-6% weight by weight for diclofenac sodium and 0.2%-1.2% weight by weight for rabeprazole sodium, and demonstrated a correlation coefficient (r²) of 0.991 and 0.991, respectively. The method that was developed was validated to ensure that it met the requirements set forth by the ICH regarding linearity, precision, accuracy, limit of detection, and limit of quantitation. In addition to this, the behaviours of deterioration of the solid state of diclofenac sodium and rabeprazole sodium were investigated by exposing them to photolysis, sunlight and thermal degradation.

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Please cite this article in press as Shaikh Naumaan Naeem et al. Quantum Dots and Their Multimodal Applications: an Overview. Indo American Journal of Pharmaceutical Research.2021:11(08).