A
simple, rapid, precise and reproducible UV-Spectrophotometric method was
developed for determination of Azelnidipine (AZEL) in bulk and tablet dosage
form using UV Visible Spectrophotometer (UV-1700) using methanol and
ortho-phosphate buffer (pH 6.5) in ratio of 50:50 and the absorbance was
measured at 256nm. The method was validated as per ICH (Q2R1) guidelines and all
the parameters for validation were found to be within acceptance criteria
limit. The percentage assay for Azelnidipine
was found to be 100.89%w/w, indicating that the excipients in the tablet
formulation did not interfere with assay values in this method. Hence the method was found to be accurate,
precise, sensitive and robust and can be successfully used for the
determination of Azelnidipine in bulk and in pharmaceutical formulations
(tablets).
