Over-the-counter medicines play a key role in public health, as they provide readily available and convenient options for self-medication. This review examines the safety, accessibility, and regulatory aspects of over-the-counter medicines. Safety considerations include the potential risks and benefits of self-medication, including side effects, interactions with other medications, and the importance of appropriate use. Accessibility examines the widespread availability of over-the-counter medicines, enabling people to manage minor health problems independently. Regulatory aspects include the regulatory framework for the manufacture, distribution and sale of over-the-counter medicines and emphasize the need for strong regulatory oversight to ensure product efficacy and consumer protection. A thorough understanding of these aspects is important for health care providers, regulators, and consumers to make informed decisions, promote responsible use of over-the-counter medications, and promote overall public health.