A Series of Bioactive compounds, 4,6-diphenyl pyridine-3(2H)-one(1a), 6-(4-cholo phenyl)-4-phenylpyridne-3(2H)-one(1b), 6-(4-amino phenyl)-4-phenyl pyridine-3(2H)-one(2a), 6-(4-nitro phenyl)-4-phenyl pyridine -3(2H)-one(2b), 6-(4-methoxy phenyl)-4-phenylpyridine-3(2H)-one(3a), were Synthesized according to the Literature methods. The Synthesized compounds were characterized by NMR, IR & Mass Spectroscopy.