The current work aims to create and define a transdermal patch loaded with Econazole for its antifungal action. The Biopharmaceutical classification system (BCS) Class II drug Econazole is a broad-spectrum imidazole antifungal. Econazole drug exhibits weak solubility causes it to be only partially absorbed after oral administration and bioavailability varies from person to person. Thus, a transdermal patch containing Econazole was developed, and more antifungal research was conducted on Tinea Pedis (Trichophyton interdigitale).Infrared spectroscopy research on the drug with the polymers suggested there was no incompatibility. The physical properties of developed transdermal patches, including thickness, weight variation, drug content, tensile strength, folding endurance, moisture content, and other critical characteristics were assessed. The present formulation study on Econazole is an effort to prepare transdermal patches and to evaluate the performance indicating that it can be used effectively to treat Tinea Pedis. This research was also designed to investigate the chance of manufacturing Econazole transdermal patches.