Abstract
A series of piperazine nucleus contained novel chalcones (RC-7 to RC-8) are synthesized by using Clasien-Schimdt reaction, in which piperazine acetophenone was condensed with various aromatic aldehydes. The yields of synthesized chalcones were obtained between 66.6 and 80.7%. Their chemical structure was elucidated by means of FT-IR and 1H-NMR (CDCl3).The synthesized compounds were screened for their in vitro antimicrobial activity against standard pathological bacterial strains (Bacillus subtilis NCIM 2063, Bacillus pumilis NCIM 2327, and Escherichia coli NCIM 2067 and Proteus vulgaris NCIM 2027) using Cylinder-plate assay method. All the compounds (RC-7 to RC-8) and standard sparfloxacin were prepared at concentration of 50μg/ml and 100μg/ml in dimethyl sulphoxide (DMSO).The synthesized chalcones have good activity against both gram positive and negative bacterial strains in dose dependent manner. From these observations, it was concluded that these novel chalcones have potential antimicrobial properties against human pathogens.