Teriflunomide is the active metabolite of leflunomide. It is an immunomodulatory agent used in the treatment of multiple sclerosis. UV spectrophotometric method has been developed for the estimation of teriflunomide in tablets using methanol as solvent. Teriflunomide has shown ? max at 293 nm. The method has been validated according to ICH Q2 (R1) guidelines. A linear response is observed (R2=0.9995) in the range of 4-20 ?g/ml, with recovery (100.68%) and precision (% RSD is 0.07).This method is simple and suitable for routine pharmaceutical analysis.