Abstract
Schiff bases derived from isatin plays a vital role in biological and pharmacological activity. The synthesis and characterization of isatin Schiff bases have been reported previously. Our work aims to predict the biological activity of isatin Schiff bases by computational method using ACD/I Lab (Software for biological activity prediction). From this software we predict Acute Toxicity (LD50, mg/kg), Median Lethal Concentration (LC50, mg/L). Isatin Schiff base has more biological activity, our study showed that 2-{[(3Z)-2-oxo-2,3-dihydro- 1H-indol-3-ylidene]amino}benzoic acid , 4-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}benzoic acid, [(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]urea and (3Z)-3-[(pyridin-2-yl)imino]-2,3-dihydro-1H-indol-2-one have more toxic against Mouse/ Intraperitoneal. In oral administration, 2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}benzoic acid, 4-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}benzoic acid and (3Z)-3-[(pyridin-2-yl)imino]-2,3-dihydro-1H-indol-2- has more activity compared to other schiff base. No hazardous fragments have been found in all the compounds. [(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene] urea shows not reliable and borderline result that indicate this schiff base do not produce toxic to living organism essential for human beings.