Abstract
Two simple and sensitive Visible Spectrophotometric methods (A, B) have been developed for the estimation of Triptans like (Eletriptan, Frovatriptan) and Asenapine maleate in pure and in pharmaceutical dosage forms. Method A is based on the reaction followed by Complexation between Potassium Ferri Cyanide and Triptans like Eletriptan and Frovatriptan in presence of Ferric chloride to form blue colored chromogen with λmax 719nm and 739.5nm, where as in Method B Triptans like Eletriptan, Frovatriptan and Asenapine maleate reacts with Folin ciocalteu (FC) reagent in an alkaline media to form blue colored chromogen with λmax 766.5nm, 767.5nm and 769nm respectively. Beer’s law is obeyed in the concentration range of 0.2-1.0µg/ml, 0.3-1.5 µg/ml for Method A and 10-50 µg/ml, 5-25 µg/ml and 4-20 µg/ml for Method B respectively. The results obtained are reproducible, statistically validated and found to be suitable for the assay of Triptans and Asenapine maleate in bulk as well as in Pharmaceutical dosage forms.