In the present Investigational work, fast dissolving tablets of Valsartan were planned to be prepared with a purposeof facilitating administration to patients experiencing problems with swallowing and improving its poor oral bioavailability,to get better disintegration, dissolution rate and bioavailability. The fast dissolving tablet will be prepared by spray drying method and are characterized for various quality control tests such as that of hardness, friability, weight variation, drug content uniformity, disintegration and dissolution.ODTs that are prepared by conventional methods usually have insufficient hardness, as well as they usually lack fast disintegration properties in the oral cavity of patient. Therefore, a fast disintegrating tablet having good mechanical strength and with required DT that could be achieved by using spray drying technique for formulation of ODT. Spray drying process and method provides a fast and cost effective way of evaporating solvents, subsequent drying and producing highly amorphous, spherical, fine powder suitable for Orodispersible tablet formulations.The ODT’s were prepared by using Crosspovidone, Crosscarmellose sodium and Sodium starch glycolate as superdisintegrants while spray dried mannitol and lactose were used as diluents. The tablet prepared by using 15% spray dried Mannitol as a diluent show lesser DT as compared to other spray dried diluents. Among all superdisintegrants 6% Crospovidone show lesser DT than other superdisintegrants, their efficiency was found in the order of CP >SSG >CCS.Batch F12 formulation containing Mannitol as a diluent and 6% Crospovidone as Superdisintegrant show lesser disintegration time i.e.15 seconds.