A Prospective observational study was carried out for the period of six months in inpatient Department of General Medicine at Vijayanagar Institute of Medical Sciences, Ballari. Objective: To study the antidiabetic drug utilization pattern in hospitalized patient with type II diabetes mellitus with or without complications. Results: A total of 200 patients were chosen for the study, 54% of the patients were males and 46% of the patients were females. Most of the patients were in the age group of 51-65 years (49.5%). The major co morbidities identified were 76 patients (38%) with cardiac complications, followed by 41 (20.5%) patients had other concurrent illness & 25 (12.5%) had nephritic complications. Antidiabetic drugs accounted for 338 of the total drugs prescribed. Among the antidiabetic, Insulin was prescribed in 159 patients, accounted for 47.04%, followed by Biguanides (Metformin) were prescribed in 114 patients, accounted for 33.73%, Sulfonylureas were prescribed in 60 patients, accounted for 17.75%, , ?- Glucosidase Inhibitor were prescribed in 02 (0.591%) patients and Meglitinide were prescribed in 03 (0.888%) patients. Antibiotics were widely used 170 (25.56%) of all prescribed drugs (n=665) followed by PPI/H2RA in 139 (20.90%) prescriptions. Conclusion: The prescribing pattern of drugs should be based on severity of disease condition, associated co morbid conditions and currently available evidences. The prescribing trend has been monotherapy with insulin followed by antidiabetic drugs in the form of Insulin and Metformin Combination.