The present research work was aimed to discover anti-viral and anti-dengue activity of the phytochemicals present in Euphorbia hirta using Molecular docking studies. In this research work, we have screened anti-dengue and anti-viral activity of 10 chemical constituents from Euphorbia hirta through docking studies, the target enzymes were chosen for the study is 3P54, 2V33, 5B1C, 4M9K and 5FC8 using Argus lab 4.0.1 software. Among the 10 screened compounds of Euphorbia hirta, shows best to moderate (-9.49194kcal/mol to –5.61913kcal/mol) binding energy and various bonding interactions against the targeted proteins. On the basis of docking study results, it can be concluded that chemical constituents of Euphorbia hirta, serve as promising chemical probes to design therapeutic agents with anti-dengue and antiviral properties.