Cluster headache is a neurological disorder characterized by recurrent, severe headaches on one side of the head, typically around the eye. This condition usually first occurs between 20 and 40 years of age. Men are affected about four times more often than women. Based on the duration cluster headaches can be classified in to acute or episodic cluster headache and chronic cluster headache. The exact cause of cluster headache is unknown. The activation of trigeminovascular,cranial parasympathetic and Internal carotid artery dilation may lead to painful vascular changes within the cavernous sinus, secondary involvement of the sympathetic plexus overlying the cavernous ceratoid artery, and stimulation of secretory function of the lacrimal and other mucosal glands. Common signs and symptoms during a headache include Excruciating pain, generally situated in or around one eye, but may radiate to other areas of your face, head, neck and shoulders ,One-sided pain. Differential diagnosis is necessary. Triptans and supplemental oxygen are first-line abortive therapies for cluster headache. Verapamil and lithium are the mainstays of treatment for chronic cluster headache. Prophylactic therapy is intended to shorten the duration of episodic cluster attacks, in addition to reducing the frequency and severity of attacks in both episodic and chronic cluster headache.