Siddha system of medicine is the renowned indigenous traditional system, provided for all the lives of earth by the scientific sages, Siddhars. The therapeutic methodology in Siddha is based mainly on three humors viz, vatham, pittham and kabam, which are when altered from its equilibrium, results in various ailments. In Siddha, etiology of a disease is mainly depicted with alterations in lifestyle, diet and environmental conditions. As a part of such modifications, PCOS is a major troublesome complication among female population in recent days. In Siddha literatures, Pararasasegaram, Yugimuni vaithiya kaaviyam, Gnanavettiyan -1500, PCOS and its associated complications may be related to sinaipai neer kattigal, soothagavaayu, soothaga kattigal, soothaga thadai, karparogam, karpa vaayu. PCOS, being a major restraint for healthy life, results in arising health issues such as hyperandrogenism, anovulatory menstrual cycle, sub-fertility, obesity, amenorrhoea and dysmenorrhoea along with insulin resistance. To overcome the adverse effects of available modern treatment, we are in need of implying the better methodology for the treatment of PCOS to sustain the growing female population of reproductive age. The objective of this review is to emphasize various Siddha formulations and available herbal-polyherbal practices for PCOS, which are depicted in the literatures possessing potential therapeutic values, are discussed with scientific validations. The management protocol ensures not only the treatment but also for the prevention and recurrence of the disease condition. The medicines practiced may be adopted for scientific validation in future for further clinical and research purposes.