The Siddha system of medicine is one of the ancient and primitive medical systems. The major strength of this Siddha system is its ease handiest, wide accessibility, naturalness of the products and cost effective. Siddha medicine has specialized therapeutic procedures for rejuvenation, health promotion and prevention. Siddha Materia Medica (Medicinal Plants Division) illustrates a safer and more potent poly herbal formulation Athimadhura Chooranam (AMC) comprised of three herbal ingredients such as Glycyrrhiza glabra, Pimpinella anisum and root bark of Plumbago zeylanica. This formulation is very effective an anti-inflammatory and analgesic. The aim of this systematic review of the literature was to summarize the literature on the safety and anti inflammatory and analgesic activity of the above herbs. Textbooks on medicinal plants, research papers and their bibliographies were also searched. These included studies on the anti-pyretic, anti-allergic, anti-bacterial, anti-viral, anti-hepatotoxic, anti-tussive & expectorant, antioxidant activity, etc, and also phyto compounds were identified. Conclusion of this review validates that all ingredients of AMC have anti inflammatory and analgesic activity based on research papers and Siddha literature.
