Novel pyrrolyl-pyrazoline methanone derivatives (5a-j) were synthesized by reacting mixture of substituted quinoline chalcones (3a-j) and 4-pyrrol-1yl benzoic acid hydrazide (4) in ethanol. The reaction mixture was heated under reflux for 16 h on a water bath followed by addition of ice cold water at room temperature and mixture was kept overnight resulting in the formations of substituted pyrrolyl-pyrazoline methanone derivatives. Purity of newly synthesized compounds were confirmed by TLC and melting point. The structure of the all newly synthesized compounds were confirmed by spectral study such as IR, 1H NMR and Mass spectroscopy. The title compounds were screened for their antibacterial and antitubercular activities.
