Thrombolytic therapy is of proven and substantial benefit for patients with Acute Ischemic Stroke. But the intracranial haemorrhage associated with thrombolysis said to be the most dreaded complication. This is a case report of thrombolysis induced intracranial haemorrhage that lead to the death of a 65year old male patient with the history of Acute Ischemic Stroke. Factors that influence risk of thrombolytic therapy associated intracranial haemorrhage are low body weight, age greater than 65years, history of Hypertension, Diabetes Mellitus, use of anticoagulant drugs before admission, heparin therapy during admission, smoking and alcoholism. Therefore patients who are at increased risk should be recognised earlier. One suggestion would be to lower the dose of thrombolytic agents, recombinant tissue Plasminogen Activator (rtPA) in patients who are at greatest risk. If these risks can be minimised through better recognition of risk factors and appropriate dosing, then the thrombolytic therapy can be effectively used.