Abstract
The conventional liposomes are present in market and having good release profile and patient compliance but they are also having some disadvantages which are overcome by making modifications in liposomes. Archaeosome is one of them and having good impact on stability related problem. Archeal lipid is obtained from the membrane lipid of the archeal domain bacteria. Varieties of bacteria are available in archaeal domain like halophiles, thermophiles, methanogens, etc. Lipid from which archaeosome is prepared, was extracted from the bacterial growth and it is a membrane lipid obtained from archaea species. For preparation of the archaeosome only two things are needed polar lipid and solvent for hydration. Evaluation of archaeosome can be done almost similar to liposome only stability test with the enzymes and lower pH is different. Application of archaeosome is also broader, it is able to incorporate both hydrophilic as well as hydrophobic drug, high as well as low molecular weight drug, vaccines, etc.