Abstract
The present communication attempts to synthesize a series of new carbazole derivatives through microwave assisted method by incorporating different pharmacophores at various positions to get therapeutically active compounds. For that fisher indolization carried out between phenyl hydrazine and cyclohexaone in the presence of glacial acetic acid to yield 1,2,3,4-tetrahydro carbazole 1(71%), which on treatment with maleic anhydride yielded compound 1a (72%) which on hydrolysis gives compound 1aˊ(76%). The compound 1 on treatment with chloroacetyl chloride yielded N9-(chloroacetylchloride)-1,2,3,4-tetrahydrocarbazole 1c (81%) which on treatment with hydrazinehydrate gives N9-(hydrazinoacetyl)-1,2,3,4-tetrahydrocarbazole 1c´(73.2%).compound 1cˊon reaction with benzaldehyde yielded N9-(benzylidine acetylhydrazino)-1,2,3,4-tetrahydrocarbazole 1cˊˊ(70%). All the synthesized compound(s) structure were confirmed by UV (λmax) and H1NMR spectral data along with elemental analysis. The synthesized compound(s) were screened for their in-vitro free radical scavenging activity using 1,1-Diphenyl-2-picrylhydrazyl (DPPH) assay showing moderate to good activity. Compound 1aˊ was found to be more active free radical scavenger at all concentrations among the other synthesized compound(s).