Abstract
The main objective was to synthesize and characterize novel 5-phenyl-1,2,4-triazolyl, benzothiazolyl and benzimidazolyl substituted pyrazoles and screen them for antimicrobial activity. The compounds were synthesized by green chemistry technique. A series of 1-(5-phenyl-1,2,4-triazol-3yl)-3,5-disubstituted pyrazoles (3a-c), 1-N-benzimidazol—2-yl-3,5-disubstituted pyrazoles (5a-c), 1-N-benzothiazol-2-yl-3,5-disubstituted pyrazoles (7a-c) were prepared from corresponding substituted 1,3-propanediones and 2-hydrazino heterocyclyl compound. Antimicrobial study of these series of compounds was implemented with respect to Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Klebsiella pneumonia. Structures of all the newly synthesized compounds were confirmed by the IR, 1HNMR and mass spectral analysis. In Antimicrobial study , the tested compound 1-(benzothiazol-2-yl)-3-(2-hydroxy- phenyl)-5-phenyl pyrazole (7c) showed potent activity against Salmonella typhi, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus and compound 1-benzimidazol-3-yl -3-(2 hydroxy-5-methyl phenyl)-5-phenyl pyrazole (5a) showed potent activity against Staphylococcus aureus, Escherichia coli. Salmonella typhi, Klebsiella pneumonia The selected compounds may be used to design more potent biologically active compounds.