Abstract
Amirtha Kanthi Kukill Vallathy (AKKV), a Siddha herbal medicine is traditionally used for Osteoarthritis to manage pain and inflammation. So the study was carried out to test the analgesic and anti inflammatory effects of AKKV drug in animal models. Analgesic activity was evaluated by Tail flick method, acute and chronic anti-inflammatory activity was evaluated by carragneenan induced paw oedema and cotton pellet granuloma in Wistar albino rats. Diclofenac sodium and indomethacin were employed as reference drugs for analgesic and anti-inflammatory studies. In the tail flick method, AKKV dosage of 500mg orally increased the tail withdrawal time significantly (P<0.001) when compared to the control group. In carrageenan induced paw oedema model, AKKV drug showed significant (P<0.001) inhibition at 1st hr, 2nd hr, 3rd hr and 4th hr. At the 3rd hr, the test drug showed maximum percentage of (66.2%) inhibition than the standard drug. The results of cotton pellet granuloma method indicated that AKKV drug significantly (P<0.001) reduced the wet (30.57%) and dry weight (48.4%) of the cotton pellet granuloma. From the result it can be concluded that the trial drug AKKV has potent analgesic and anti inflammatory properties which confirmed the traditional use of this drug for clinical conditions.