Abstract
Solubility is one of the important parameter to attain desired concentration of drug in systemic circulation for pharmacological response to be shown. It is vital to improve the solubility and dissolution rate for poorly soluble drugs since these drugs possess low absorption and bioavailability. About 40% of all new chemical entity has poor bioavailability. Increasing the bioavailability of poorly soluble drugs will be one of the biggest challenges for formulation scientists in the future. This review is intended to discuss thoroughly the various traditional novel techniques like sono crystallization, spray freezing in to liquid, pearl milling, solid dispersion, salt formation and pH adjustment etc. for solubility enhancement of hydrophobic drugs for oral pharmaceutical formulation and also tried to focus on the polymers used for to achieve solubility enhancement, process of Solubilization and factor affects on it. In this article we focused on, solubility of the drug is the most significant factor and prime requirement for to achieve good bioavaibility after the absorption of drug so it is most critical factor in the formulation development.