Abstract
A series of 5-substituted phenyl-N-(6-(propylthio)-1H-benzo[d]imidazol-2-yl)-1, 3, 4-oxadiazol-2-amines were prepared by treating substituted 2-benzylidene-N-(6-(propylthio)-1H-benzo[d]imidazol-2-yl) hydrazine carboxamides with Chloramine T. The newly synthesized derivatives were screened against cytotoxic activity using MTT assay method using MCF, HEPG2 and HCT-116. The compounds showed dose dependent activity. Among the compounds showed IVC (4-Cl) was active against MCF, IVB (4-OH) was active against HCT-116,IVA (H) was active against HEPG2 cell lines.