Abstract
Objective: To evaluate the anti-diabetic activity of ethanolic extract of Lygodium flexuosum (L) on alloxan induced diabetic rats. Methods: Diabetes was induced in Wistar rats by intraperitoneal injection of alloxan monohydrate (100mg/kg b.w/i.p). Ethanolic extract of Lygodium flexuosum (L) (100, 200mg/kg b.w/p.o) was prepared freshly, administered to alloxan induced diabetic rats for 14 days. Blood glucose levels monitored at 1, 3, 5, 7 and 14 days, serum lipid profile and Histopathological changes in pancreas were examined after 14 days. OGTT was performed by administration of 100 and 200 mg/kg b.w/p.o of ethanolic extract of Lygodium flexuosum (L) and 10 mg/kg b.w/p.o of Glibenclamide to different groups respectively in normal rats. Results: significant (p<0.001) results were observed in the estimated parameters like reduction in blood glucose, elevated cholesterol, triglyceride, VLDL, LDL levels and also increase in the levels of HDL were observed in diabetic rats treatment after 14 days of extract. Improved in regeneration of β-cells of langerhans of pancreas in rats by histopathological studies. Oral glucose tolerance test, blood glucose levels significantly lower at all time points (In extract and standard Wistar rats) that blood was sampled after oral glucose load. Conclusion: The results were suggested that the whole plant extract of Lygodium flexuosum (L) having potent Antidiabetic activity on alloxan-induced diabetic rats and this justifies its use in ethanomedicine and can be exploited in the management of diabetes.