Abstract
Timed release matrix suppositories as reliable rectal drug delivery by passing hepatic metabolism. Various bases like agar, sodium carboxy methyl cellulose (SCMC), polyethylene glycol used to formulate this. In addition, these bases if used in the formulation will have flexibility in storage conditions unlike suppositories formulated with conventional bases that necessitate exacting storage conditions in tropical climate. Unconventional, non-melting, non-disintegrating suppositories prepared and examined for physicochemical characteristics and in vitro release kinetics. Timed release matrix suppository adapting unconventional combinations of bases such as agar, polyethylene glycol for better prolonged release and mainly to reduce severe gastric ulceration, bleeding and hepatotoxicity.