Abstract
Fast disintegrating tablets are the solid dosage forms consists of drugs that disintegrate in the oral cavity within less than one minute leaving an easy to swallow residue and becomes convenient especially for elderly &children who have swallowing difficulties. Loratidine is a long acting tricyclic peripherally acting histamine antagonist with selective peripheral H1 antagonist activity. It is usually used alone or in combination with pseudoephedrine sulphate for the symptomatic relief of seasonal allergic rhinitis, pruritis, erythemia & urticaria associated with chronic idiopathic urticaria. The oral bioavailability of Loratidine is around 40% due to its less solubility with biological half life of 8.4 hrs. In the present work FDT of Loratidine were prepared primarily using solid dispersion to enhance solubility & then FDT’s were prepared using synthetic superdisintegrants viz crosspovidone & Mcc. The prepared tablets were evaluated for Pre & post compressional parameter . The FDT’s using solid dispersion & synthetic superdisintegrants passess weight variation in the range of 100 ± 0.65 SD to 103 ± 0.86 SD & hardness was 2.6 to 2.8. % Friability 0.819 to 1.157 disintegration time was 30-53 seconds & in-vitro drug release 73.05 to 94.14% at the end of 30mins & which was fitted to pharmacokinetic model & it shows zero order drug release. From FTIR study reveals that there is no interaction between drug & the excipients used for FDT. The results concluded that FDT of Loratidine showing increased dissolution rate may lead to increased bioavailability by using solid dispersion.