Welcome to Indo American Journal of Pharmaceutical Research

AUGUST 2019

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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SIMULTANEOUS DETERMINATION OF METFORMIN AND GLIBENCLAMIDE IN PHARMACEUTICAL PREPARATION BY RP-HPLC

Anitha K¹, T. M. Kalyankar², V. B. Ingale² and Ashok P Gingine³

¹Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram-515003, Andhra Pradesh, India.

²School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.

³School of Educational Sciences, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.

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A VALIDATED RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ARTESUNATE, SULFADOXINE AND PYRIMETHAMINE IN BULK AND TABLETS FORMULATION

Anitha K¹, T. M. Kalyankar², Khan Jawad S. A.² and Ashok P Gingine³
¹Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram-515003, Andhra Pradesh, India.
²School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.
³School of Educational Sciences, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.

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A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

FORMULATION DEVELOPMENT AND EVALUATION OF ORODISPERSIBLE TABLETS OF VALSARTAN USING SPRAY DRIED DILUENTS

MahaleNitin B^*1, Battase A.P².
¹Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
²GovindraoNikam College of Pharmacy, Sawarde, Tal ChiplunDistRatnagiri, (M.S), India.

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FORMULATION DEVELOPMENT AND EVALUATION OF NOVEL ORODISPERSIBLE TABLETS OF OLMESARTAN

Mahale Nitin B^*1, Battase A.P².
¹Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
²GovindraoNikam College of Pharmacy, Sawarde, Tal ChiplunDistRatnagiri, (M.S), India.

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ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLET OF AZATHIOPRINE

Kadam Sagar*, Abnave Dattatray, Landge Dhananjay
Hon. Shri. Babanrao Pachpute Vichardhara Trust’s, Group of Institutions, College of Pharmacy, Kashti, Ahmednagar, Maharashtra, India.

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FORMULATION AND EVALUATION OF HYDROXYAPATITE MICROSPHERES OF AN ANTIMICROBIAL DRUG FOR THE TREATMENT OF OSTEOMYELITIS

S. J. Shankar*, Jaswanth Gowda B. H., Nimitha A.G., Basavaraj Metikurki
Vivekananda College of Pharmacy, Dr. Rajkumar Road, Rajajinagar 2nd Stage, Bengaluru – 560 055.

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CO-CRYSTALLIZATION: A NOVEL APPROACH TO ENHANCE THE DISSOLUTION OF POORLY SOLUBLE DRUGS

S. J. Shankar1*, Jaswanth Gowda B. H.¹, Akshatha R. S.², Basavaraj Metikurki¹
¹Vivekananda College of Pharmacy, Dr. Rajkumar Road, Rajajinagar 2nd Stage, Bengaluru – 560 055.
²PES College of Pharmacy, 50 feet Road, Hanumanth nagar, Srinagara, Bengaluru – 560 050.

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MOLECULAR DOCKING STUDIES OF SOME NOVEL N-ARYLSUBSTITUTED PYRROLE ANALOGS

Shrinivas D. Joshi* S. R. Prem Kumar, and Venkatrao H. Kulkarni
Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, S. E. T’s College of Pharmacy, Sangolli Rayanna Nagar, Dharwad 580 002, Karnataka, India.

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FUTURE ASPECT OF NANOMEDICINE

Dhanashree B. Midgule, Sutaja L. Ingale, Sayali C. Dudhal, Geetanjali S. Mehetre
Department of Pharmaceutical Chemistry ,KasturiShikshanSanstha College of Pharmacy, Shikrapur, Pune-412208.
Department of Pharmaceutics, Kasturi Shikshan Sanstha College of Pharmacy, Shikrapur, Pune-412208.

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ANTIMICROBIAL POTENTIAL OF A NOVEL SIDDHA METALLO-MINERAL FORMULATION KAALAMEGA NARAYANA CHENDHOORAM AS MENTIONED IN ATHMARAKSHA MIRTHAM ENNUM VAITHIYA SAARA SANGERAHAM AGAINST A GRAM NEGATIVE ORGANISM E.Coli IN IN-VITRO STUDIES.

Dr. R. Abinaya, Dr. R. Vijaya Nirmala, Dr. R. Karolin Daisy Rani, Dr. M. D. Saravana Devi.
Government Siddha Medical College, Arumbakkam,Chennai, Tamil Nadu, India.

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AIM AND OBJECTIVE: The aim of this present study is to validate the Anti microbial potentials of a novel siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham against a Gram negative organism Escherichia coli in in-vitro Studies. METHODS: Siddha system of medicine was a fruitful gift offered by the siddhars. It contains plants, metals, minerals and animal products in their medicinal preparations. It involved in treating various acute and chronic diseases. Siddha system of medicine had a history of antimicrobial medicine before the prehistoric era of antibiotics. Due to the lack of proper validations of medicine, it was not accepted by the scientific world. Thus an attempt was made in this paper to screen the efficacy of anti microbial potentials of Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham, a novel siddha metallo-mineral formulation against a Gram negative organism Escherichia coli in In-vitro Studies of Muller Hinton Agar Medium with streptomycin as a standard drug and test drug with the different concentration of the drug as 250?g/ml, 500?g/ml, 1000 ?g/ml were added and zone of inhibitions were measured in mm. RESULTS: At the end of this research study, that the trail drug of a novel siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through Muller Hinton Agar Medium with streptomycin as standard drug. The gram negative organism showed the zone of inhibition in following concentration of Escherichia coli 250?g/ml, 500?g/ml, 1000 ?g/ml as 15mm,16mm, 19mm .On increasing the concentration of the drug there is a gradual increase in the zone of inhibition of micro organisms. CONCLUSION: The present in-vitro study of a potent siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a Muller Hinton Agar Medium with streptomycin as a standard drug was found to be a potent anti-microbial medicine.

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AIM AND OBJECTIVE: The aim of this present study is to validate the Anti microbial potentials of a novel siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham against a Gram negative organism Escherichia coli in in-vitro Studies. METHODS: Siddha system of medicine was a fruitful gift offered by the siddhars. It contains plants, metals, minerals and animal products in their medicinal preparations. It involved in treating various acute and chronic diseases. Siddha system of medicine had a history of antimicrobial medicine before the prehistoric era of antibiotics. Due to the lack of proper validations of medicine, it was not accepted by the scientific world. Thus an attempt was made in this paper to screen the efficacy of anti microbial potentials of Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham, a novel siddha metallo-mineral formulation against a Gram negative organism Escherichia coli in In-vitro Studies of Muller Hinton Agar Medium with streptomycin as a standard drug and test drug with the different concentration of the drug as 250?g/ml, 500?g/ml, 1000 ?g/ml were added and zone of inhibitions were measured in mm. RESULTS: At the end of this research study, that the trail drug of a novel siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through Muller Hinton Agar Medium with streptomycin as standard drug. The gram negative organism showed the zone of inhibition in following concentration of Escherichia coli 250?g/ml, 500?g/ml, 1000 ?g/ml as 15mm,16mm, 19mm .On increasing the concentration of the drug there is a gradual increase in the zone of inhibition of micro organisms. CONCLUSION: The present in-vitro study of a potent siddha metallo-mineral formulation Kaalamega Narayana Chendhooram as mentioned in Athmaraksha Mirtham Ennum Vaithiya Saara Sangeraham through a Muller Hinton Agar Medium with streptomycin as a standard drug was found to be a potent anti-microbial medicine.

A VALIDATED CHIRAL HPLC METHOD FOR THE ENANTIOMERIC PURITY OF ANAGLIPTIN

K. Durga Malleswar¹, B. Venugopala Rao^*1, S.Shylaja².
¹Stereokem Private Limited. Plot No-36/A, IDA, Uppal, Hyderabad, Telangana, India.
²Chaitanya Bharathi Institute of Technology ,Gandipet, Hyderabad, Telangana, India.

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DESIGN, DEVELOPMENT AND EVALUATION OF BUCCAL MUCOADHESIVE PATCH OF DEXAMETHASONE SODIUM PHOSPHATE FOR THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS, ULCERATION AND LICHEN PLANUS

Satish Polshettiwar², Saroj Valvi¹, Akshay Baheti², B. S. Kuchekar²
¹MAEERS, Maharashtra Institute of Pharmacy, MIT Campus, Kothrud, Pune-411038, Maharashtra, India.
²Dr Vishwanath Karad MITWPU, School of Pharmacy, Pune-411038.

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The objective of the present study was to develop mucoadhesive buccal patch of Dexamethasone for the treatment of oral submucous fibrosis. In formulation, chitosan is used as a polymer and PEG 400 as a plasticizer. Backing membrane was prepared by using ethyl cellulose and isopropyl alcohol. The solvent casting method was used for the preparation of mucoadhesive buccal patch as it is cost effective and efficient method. Preformulation studies of Dexamethasone were carried out. FTIR studies implied that there were no interactions between drug and polymers. The prepared batches were evaluated for visual appearance, thickness, folding endurance, weight variation, swelling index, surface pH, mucoadhesive time, % drug content, in-vitro diffusion and ex-vivo permeation study. Total nine batches of Dexamethasone mucoadhesive buccal patch were prepared successfully using chitosan as a polymer and PEG 400 as a plasticizer by solvent casting method. Based on results batch F2 was selected as optimized formulation. From invitro release of batches, F2 was found best, showing release of drug 64.53% in 4 hours. A clinical examination of the oral cavity was carried out under artificial light which includes extra oral examination and intra oral examination. The results of the present study of mucoadhesive semi-solid drug design for the treatment of OSMF will be useful for drug industry for the benefit of patients suffering from OSMF. The most important advantage of the Mucoadhesive buccal films is that it contains a lower drug dose, adequate for therapeutic effect as it is placed directly on the site of the inflammation, when compared to conventional administration. Moreover, this Mucoadhesive buccal patch is very convenient because it is non-irritant and self-administration is possible. Given promising therapeutic effects, the buccal film developed here could become a local drug delivery device for management of oral submucous fibrosis, ulceration and lichen planus.

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The objective of the present study was to develop mucoadhesive buccal patch of Dexamethasone for the treatment of oral submucous fibrosis. In formulation, chitosan is used as a polymer and PEG 400 as a plasticizer. Backing membrane was prepared by using ethyl cellulose and isopropyl alcohol. The solvent casting method was used for the preparation of mucoadhesive buccal patch as it is cost effective and efficient method. Preformulation studies of Dexamethasone were carried out. FTIR studies implied that there were no interactions between drug and polymers. The prepared batches were evaluated for visual appearance, thickness, folding endurance, weight variation, swelling index, surface pH, mucoadhesive time, % drug content, in-vitro diffusion and ex-vivo permeation study. Total nine batches of Dexamethasone mucoadhesive buccal patch were prepared successfully using chitosan as a polymer and PEG 400 as a plasticizer by solvent casting method. Based on results batch F2 was selected as optimized formulation. From invitro release of batches, F2 was found best, showing release of drug 64.53% in 4 hours. A clinical examination of the oral cavity was carried out under artificial light which includes extra oral examination and intra oral examination. The results of the present study of mucoadhesive semi-solid drug design for the treatment of OSMF will be useful for drug industry for the benefit of patients suffering from OSMF. The most important advantage of the Mucoadhesive buccal films is that it contains a lower drug dose, adequate for therapeutic effect as it is placed directly on the site of the inflammation, when compared to conventional administration. Moreover, this Mucoadhesive buccal patch is very convenient because it is non-irritant and self-administration is possible. Given promising therapeutic effects, the buccal film developed here could become a local drug delivery device for management of oral submucous fibrosis, ulceration and lichen planus.

SYNTHESIS, SPECTRAL AND MICROBIAL STUDIES OF QUINAZOLIN-4-ONE BASED SOME NEW CHALCONES DERIVATIVES.

Komal Savaliya and Pankaj S. Patel
Department of Chemistry, Sheth L.H. Science College, MANSA-382845, Gujarat, India.

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FORMULATION AND EVALUATION OF RANITIDINE SEMISOLID MATRIX CAPSULE BY LIQUID FILLING TECHNOLOGY

Kadam Sagar^*1, Dr. Kshirsagar Sandip², Shinde Vaishali²
¹Hon.Shri. Babanrao Pachpute Vichardhara Trust’s, Group of Institutions, College of Pharmacy, Kashti, Ahmednagar, Maharashtra, India
²Kasturi Shikshan Sanstha, College of Pharmacy, Shikrapur, Pune, Maharashtra, India.

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MICROSPONGES A COMPREHENSIVE REVIEW: SUCCESS AND CHALLENGES

G. Ravi, Valluru Ravi*, P. Subhash Chandra Bose, Damineni Saritha
Department of Pharmaceutics, MNR College of Pharmacy, Sangareddy-502294, TS, India.
Department of Pharmaceutics, Sultan-Ul-Uloom College of Pharmacy, Hyderabad, TS, India.

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A REVIEW ON QUALITY BY DESIGN APPROACHES TO ANALYTICAL METHOD DEVELOPMENT

Rajendra Phadke^1*, Dr. Amit Gosar², Rupali Mali², Deepesh Patil²
¹J.J.T University, Churu, Jhunjhunu Road, Rajasthan -333001.
²Indoco Remedies Limited, Analytical Research & Development Department, Navi Mumbai, 400701, Maharashtra, India.

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SYNTHESIS AND CHARACTERIZATION OF POTENTIAL IMPURITIES IN CHLOROQUINE PHOSPHATE

Ware Agasti L.*, Pekamwar S.S.¹
¹Sanjivani College of Pharmaceutical Education and Research, Kopargaon
²Swami Ramanand Teerth Marathwada University, Nanded.

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IMPURITY PROFILING AND QUALITY BY DESIGN

Ware Agasti L.*, Pekamwar S.S.
¹Sanjivani College of Pharmaceutical Education and Research, Kopargaon.
²Swami Ramanand Teerth Marathwada University, Nanded.

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DEVELOPMENT CHARACTERIZATION AND IN-VITRO EVALUATION OF POROUS NANOPARTICLES CONTAINING STATIN DRUG

Bharath G.J*, Yogananda R, Nagaraja T.S, Vitthal K Vijapure, Bharathi D.R
SJM College of Pharmacy SJM Campus, Chitradurga, Karnataka, India.

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BREAST CANCER: A GLOBAL CHALLENGE

Sandip S. Kshirsagar, Vaishali R. Shinde, Manjusha Nevase, Sayali Dudhal
Kasturi Shikshan Sanstha’s College of Pharmacy, Shikrapur, Pune-412207, Maharashtra, India.

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REVIEW ON BIOMARKERS: TOOL FOR DIAGNOSIS OF A DISEASE AND DRUG DEVELOPMENT

Sandip S. Kshirsagar, Vaishali R. Shinde, Manjusha Nevase, Sayali Dudhal
Kasturi Shikshan Sanstha’s College of Pharmacy, Shikrapur, Pune-412207, Maharashtra, India.

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TO ASSESS THE QUALITY OF LIFE IN PEDIATRIC LEUKEMIC PATIENTS

K.Yogendra*, S. Rajini, V.Mohana, G.V.Chari, P.Supraja, M.Prasada Rao
M.A.M College of Pharmacy, Narsaraopeta, Guntur District, A.P.

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Introduction: Quality of Life assessment has become increasingly common in the field of cancer and has been identified as the second most important outcome with survival being the most important. For patients and their family, a diagnosis of cancer brings challenges to many aspects of daily life, with a major concern being maintaining the highest quality of life possible during and after the experience. This study was carried out with the objective of measuring the quality of life of pediatric leukemic patients during their cancer treatment. Materials and Methodology: The data required for the study was collected from the patients at Primary Healthcare Hospital. The data is collected from Leukemic pediatric patients who were in the Oncology department. The Quality of Life was measured by using PedsQL, A prominent Quality assessing scale for pediatrics. The data was computed from the patient data collection forms. Data pertaining to physical functioning, emotional functioning, social functioning, school functioning characteristics of patients was stockpiled. Results: Physical Functioning ( P > 0.05), Emotional Functioning ( P > 0.05), Social Functioning ( P > 0.05), School functioning ( P > 0.05). The significance (2 tailed) values Emotional Functioning implicate that most of the patients have angry. The significance (2 tailed) values Social Functioning implicate that most of the patients getting teased by other children. The significance (2 tailed) values School Functioning implicate that most of the patients have problems with paying attention in classs, keeping up with school work, missing school because of not feeling well, missing school to go to doctor or hospital. Conclusion: Anxiety, irritability, worries, depression, and aggression were also sometimes a barrier to communicate with the patients and for them to complete the questionnaire. It should be noted that the approximate time to enter the study for this number of subjects (n = 49) was 3 months. Another limitation was the limited environment of the study; due to this limitation, studying patients with leukemia admitted in other hospitals at the same time was not possible. Based on the limitations of this study, including the small number of subjects, applying the study only in one hospital, and in only one section, and the problems of generalizability, it is recommended for further similar studies to be conducted in other hospitals with larger sample size.

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Introduction: Quality of Life assessment has become increasingly common in the field of cancer and has been identified as the second most important outcome with survival being the most important. For patients and their family, a diagnosis of cancer brings challenges to many aspects of daily life, with a major concern being maintaining the highest quality of life possible during and after the experience. This study was carried out with the objective of measuring the quality of life of pediatric leukemic patients during their cancer treatment. Materials and Methodology: The data required for the study was collected from the patients at Primary Healthcare Hospital. The data is collected from Leukemic pediatric patients who were in the Oncology department. The Quality of Life was measured by using PedsQL, A prominent Quality assessing scale for pediatrics. The data was computed from the patient data collection forms. Data pertaining to physical functioning, emotional functioning, social functioning, school functioning characteristics of patients was stockpiled. Results: Physical Functioning ( P > 0.05), Emotional Functioning ( P > 0.05), Social Functioning ( P > 0.05), School functioning ( P > 0.05). The significance (2 tailed) values Emotional Functioning implicate that most of the patients have angry. The significance (2 tailed) values Social Functioning implicate that most of the patients getting teased by other children. The significance (2 tailed) values School Functioning implicate that most of the patients have problems with paying attention in classs, keeping up with school work, missing school because of not feeling well, missing school to go to doctor or hospital. Conclusion: Anxiety, irritability, worries, depression, and aggression were also sometimes a barrier to communicate with the patients and for them to complete the questionnaire. It should be noted that the approximate time to enter the study for this number of subjects (n = 49) was 3 months. Another limitation was the limited environment of the study; due to this limitation, studying patients with leukemia admitted in other hospitals at the same time was not possible. Based on the limitations of this study, including the small number of subjects, applying the study only in one hospital, and in only one section, and the problems of generalizability, it is recommended for further similar studies to be conducted in other hospitals with larger sample size.

FORMULATION AND EVALUATION OF NIOSOMES OF MIRTAZAPINE FOR NASAL DELIVERY

Sayeda Salma .S .A^*, Asha A N, V Kusum Devi

Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore, Hosur Road, Opposite Lalbagh Main Gate, Karnataka, India.

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LIPOSOMES: RECENT INSIGHT FOR BRAIN TARGETING

Zahid Anwer1, Pankaj Nerkar1*, Shailesh Chalikwar1
R C Patel Institute of Pharmaceutical Education and Research, Shirpur.

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DEVELOPMENT AND VALIDATION OF NEW ANALYTICAL METHOD FOR THE SIMULTANEOUSS ESTIMATION OF PANTOPRAZOLE AND DOMPERIDONE BY UV-SPECTROPHOTOMETRY

Barri Swathi*, B.Subramanyam, B.Dharmateja, M.Hari Babu, D.Kiran
Rao`S College of Pharmacy, Buja Buja Nellore, Nellore, AP, India.

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TO ASSESS THE DRUG ADHERENCE, FACTOR AFFECTING ADHERENCE AND MANAGEMENT OF ACUTE ASTHMA CHILDRENS IN TAMILNADU

Arulprakasam K C^1*, Senthilkumar N²
¹Research Scholar, PRIST University, Tanjavuor, Tamilandu.
²JKKMMRFS Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam, Namakkal DT, Tamilnadu.

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The prevalence and associated burden of disease due to asthma, it is mandatory to obtain an optimal control of the disease and to improve outcomes for these patients. But it has been observed that there is very poor adherence to the therapy which leads to the suboptimal control of the disease. To study the adherence for therapy in asthma patients and to assess the impact of health education and self action plan in improving the adherence to the therapy. A prospective study was done in a total of 986 asthma patients over a period of 3 years. Once included in the study, the patients were followed up for a total of 12 weeks for calculation of non-adherence to the therapy. In non-adherent patients, we employed various health education strategies to improve the adherence in these cases. A total of 986 patients of asthma who were started on therapy over duration of 6 months were included in the study. At the end of 12 weeks, it was observed that, only 108 patients (10.95%) had regular adherence and 878 patients (89.05%) were non adherence to the therapy as prescribed for asthma. Factors that were associated with poor adherence were: Lower educational level status, poor socioeconomic status, cumbersome regimens, dislike of medication, Fears about side effects, beliefs, changing in regimen, and patients ill attitudes toward health. After employing the various strategies for improving the adherence in these patients, the adherence increased in patients (61.32%) among the earlier defaulted patients, while the remaining 188 patients (38.68%) were found to be non-adherence even after various educational techniques. Nonadherence in asthma management is a fact of life and no single adherence improving strategy probably will be as effective as a good physician and patient relationship. Optimal self-management allowing for optimization of asthma control by adjustment of medications may be conducted by either self-adjustment with the aid of a written action plan or by regular medical review. Individualized written action plans based on peak expiratory flow are equivalent to action plans based on symptoms.

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The prevalence and associated burden of disease due to asthma, it is mandatory to obtain an optimal control of the disease and to improve outcomes for these patients. But it has been observed that there is very poor adherence to the therapy which leads to the suboptimal control of the disease. To study the adherence for therapy in asthma patients and to assess the impact of health education and self action plan in improving the adherence to the therapy. A prospective study was done in a total of 986 asthma patients over a period of 3 years. Once included in the study, the patients were followed up for a total of 12 weeks for calculation of non-adherence to the therapy. In non-adherent patients, we employed various health education strategies to improve the adherence in these cases. A total of 986 patients of asthma who were started on therapy over duration of 6 months were included in the study. At the end of 12 weeks, it was observed that, only 108 patients (10.95%) had regular adherence and 878 patients (89.05%) were non adherence to the therapy as prescribed for asthma. Factors that were associated with poor adherence were: Lower educational level status, poor socioeconomic status, cumbersome regimens, dislike of medication, Fears about side effects, beliefs, changing in regimen, and patients ill attitudes toward health. After employing the various strategies for improving the adherence in these patients, the adherence increased in patients (61.32%) among the earlier defaulted patients, while the remaining 188 patients (38.68%) were found to be non-adherence even after various educational techniques. Nonadherence in asthma management is a fact of life and no single adherence improving strategy probably will be as effective as a good physician and patient relationship. Optimal self-management allowing for optimization of asthma control by adjustment of medications may be conducted by either self-adjustment with the aid of a written action plan or by regular medical review. Individualized written action plans based on peak expiratory flow are equivalent to action plans based on symptoms.

ANTI-HYPERLIPIDEMIC ACTIVITY OF ACACIA NILOTICA PODS EXTRACT AGAINST FRUCTOSE INDUCED HYPERLIPIDEMIA

Shrinivas K Sarje*, Varsha Kadam, Snehal Rasale, Vikas Shiradhonkar, Nitin B Ghiware
Department of Pharmacology, Nanded Pharmacy College, Nanded, Maharashtra.

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