Welcome to Indo American Journal of Pharmaceutical Research

MAY 2018

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ANTIVIRAL DRUGS, GRAZOPREVIR AND ELBASVIR, SIMULTANEOUSLY IN BULK AND IN TABLETS

Pallapati Suman^1,2*, Tirukkovalluri Siva Rao¹, Kallam Venkata Siva Rama Krishna Reddy²
¹Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India - 530003.
²Laurus Labs Limited, Visakhapatnam, Andhra Pradesh, India - 531021.

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DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF LETROZOLE IN PURE AND PHARMACEUTICAL DOSAGE FORM

Siddharth M. Patil^*, Sunil T.Galatage, Avinash U.Choudhary
Department of Pharmaceutics, KLE’S College of Pharmacy, Nippani, Karnataka, India.

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A REVIEW ON TOPICAL LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM

Lalita Devi^*, Punam Gaba, Dr. Sandeep Kumar
Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Ropar).

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AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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CLINICAL PHARMACIST IS KEY ROLE OF THE PATIENT-CENTERED CARE IN TERTIARY CARE TEACHING HOSPITALS IN INDIAN SENERIO

Venkata Ramarao Nallani^*1, Prof.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, PAHER University, Udaipur.

⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

RECENT ADVANCES IN PILOT PLANT SCALE UP TECHNIQUES - A Review

AvinashV.Dhobale^*1, Arun M.Mahale², Mrunal Shirsat³, Shriram Pethkar⁴, Vijay Chakote⁵
¹LCOP Hasegaon.
²SNIOP,Pusad.
³Dr. N. JPaulbudhe College of Pharmacy Ahamadnagar.
⁴Latur College of Pharmacy (B.Pharm), Hasegaon.
⁵Atsvp College of Pharmacy Hatta.

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LIPID LOWERING ACTIVITY OF A POLYHERBAL FORMULATION ON TRITON WR-1339 (TYLOXAPOL) INDUCED HYPERLIPIDEMIA IN WISTAR RATS

Sudharshan Reddy Dachani, Kenneth Nelson
Department of Pharmacy Practice, College of Pharmacy-Boys, Shaqra University, Al-Dawadmi, K.S.A-1678.

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ANTIHYPERGLYCEMIC ACTIVITY OF HOLOSTEMMA ANNULARIS K. SCHUM ROOT EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

Srinivasa Rao Avanapu¹, Sudharshan Reddy Dachani^*2
¹Bhaskar Pharmacy College, Department of Pharmacology, Yenkapally (Vi) Moinabad (Mo), Hyderabad.
²Nizam Institute of Pharmacy, Deshmuki (Vi), Pochampally (Mo), Nalagonda (Di) 508284, Andhra Pradesh, India. Hyderabad.

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NEW APPROACHES FOR SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG: - AN OVERVIEW

Shruti Jaswal, Rajeev Garg*
Department of Pharmaceutics, A.S.B.S.J.S.M. College of Pharmacy, Bela, 140111(Punjab), India.

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A Comparative Study of Metformin plus Sulfonylureas Versus Metforminalone for Its efficacy In Type 2 Diabetes patients In South Indian Tertiary Care Teaching Hospital

Narasimha Rao.B¹, Lokesh .A¹, Lahoor Basha. S^1*, Prashanth.M¹, Vijaya Narasimha Reddy.P².
¹P.Ramireddy Memorial College of Pharmacy, Cuddapah, Andhra Pradesh-506003, INDIA.
²Rajiv Gandhi Institute of Medical Sciences, Cuddapah, Andhra Pradesh-506003, INDIA.

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NEUROBLASTOMA AND ITS THERAPY - A REVIEW

Sk. Seshma Ifthulla*, P. Hari Priya*, Dr. G. Susmitha, Dr. G. Ramesh, Dr. V. Tejaswi, Satheesh. S. G, Dr. P. Srinivasa Babu
Department of Pharmacy Practice, Vignan Pharmacy College, Guntur.

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STUDY OF DRUG-DRUG INTERACTIONS IN INPATIENTS ADMITTED TO DEPARTMENT OF GENERAL MEDICINE AT A TERTIARY CARE TEACHING HOSPITAL, BALLARI KARNATAKA

Dr. RoopaShree P.M^*, Dhruba Rana Chhetri, Varun Lal, Sujit Kumar Sah, Sahithi Reddy D, Kotha Ashok Guptha
Department of Pharmacy Practice, TVM College of Pharmacy, Ballari, Karnataka.

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PREDNISOLONE INDUCED CUSHINGS SYNDROME IN SEROPOSITIVE INFLAMMATORY ARTHRITIS: A CASE REPORT

Sharad Chand^*, Ramesh Bhandari, Varun Lal
Department of Pharmacy Practice, TVM College of Pharmacy, Ballari, Karnataka-583103.

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AN ATTITUDE & KNOWLEDGE OF PHARMACISTS TOWARDS PHARMACOVIGILANCE & ADR REPORTING AND BARRIERS - A CURRENT SCENARIO IN TAMILNADU

D. Krishnarajan*, Mathiyazhagan G, Tamilselvan A, A. Srinivasan, Sivasakthi K, B. Shiva Ranjini, S. Kalaivani
JKKMMRFs AJKK SA College of Pharmacy, Komarapalayam, Namakkal - 638183, Tamilnadu, India.
The Tamilnadu Dr.MGR Medical University, Chennai, Tamilnadu.

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FORMULATION DEVELOPMENT AND EVALUATION OF CHEWABLE TABLET OF BENZOCAIN BY DIFFERENT BINDER CONCENTRATION

Mr. Sonawane M.P.¹, Miss Gangurde R. R.¹, Miss Bagul P.K.¹, Mrs. Sonawane B. M.²
¹Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy. Manur, Kalwan.
²Department of Pharmacognosy, Loknete Dr. J. D. Pawar College of Pharmacy. Manur, Kalwan.

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A REVIEW OF ADULTERATION IN HERBAL MEDICINE WITH DIFFERENT CLASS ALLOPATHIC DRUGS

Ajay I Patel^1*, NP Jivani²
¹B.K. Mody Government Pharmacy College, Rajkot, Gujrat, India.
²Smt, R.B. Patel Mahila Pharmacy College, Atkot, Rajkot, Gujrat, India.

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PROTECTIVE EFFECT OF AERVA LANATA LINN., FLOWER EXTRACT AGAINST IMMOBILISATION STRESS INDUCED GASTRIC ULCERS IN RATS

Mr. Balakrishna Vuyyala*, Dr. Takkalapally Lakshmi
Department of Pharmacology, GNITC-School of Pharmacy, Ibrahimpatnam, Hyderabad.

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The purpose of this study was to assess the effect of ethanolic extract of Aerva lanata linn., flower in experimentally immobilization stress induced Gastric ulcers in rats. Rats were divided into six different groups each having six. Group 1 served as a control, Group 2 received immobilisation stress (daily 1hr), Group 3, 4 and 5 served as extract treatment groups and received 50, 100, & 200 mg/kg orally, ethanolic extract of Aerva lanata flower and Group 6 served as standard group was received Ranitidine (20 mg/kg) orally. All the treatment protocols followed 15 days and after which rats were sacrificed, blood and stomach were taken for biochemical and Ulceration studies, respectively. The immobilisation stress treated group rats (G2) showed variable increase in serum Total protein, Total cholesterol, Triglycerides, Glucose, ALT, and ALP levels. Administration of ethanolic extracts of Aerva lanata linn., flower significantly prevented immobilisation stress induced elevation in the levels of serum diagnostic enzymes alanine amino transferase (ALT) and alkaline phosphatase (ALP), levels in experimental groups of rats. Moreover, total protein levels were significantly increased in treatment groups. The effect of extract was compared with a standard drug (Ranitidine). The changes in biochemical parameters were supported by histological profile. It is concluded that the ethanolic extract of Aerva lanata flower protects against immobilisation stress induced gastric ulcers in rats. In the present study treatment with Aerva lanata flower extract significantly decreased the elevated levels of Glucose, ALT, ALP, Triglyserides, glucose and increased the levels of Total proteins. From the results indicated that the ulcer protective activity of Aerva lanata flower may be due to the presence of several biochemical compounds. It is thus apparent that Aerva lanata possesses an ulcer protective activity.

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The purpose of this study was to assess the effect of ethanolic extract of Aerva lanata linn., flower in experimentally immobilization stress induced Gastric ulcers in rats. Rats were divided into six different groups each having six. Group 1 served as a control, Group 2 received immobilisation stress (daily 1hr), Group 3, 4 and 5 served as extract treatment groups and received 50, 100, & 200 mg/kg orally, ethanolic extract of Aerva lanata flower and Group 6 served as standard group was received Ranitidine (20 mg/kg) orally. All the treatment protocols followed 15 days and after which rats were sacrificed, blood and stomach were taken for biochemical and Ulceration studies, respectively. The immobilisation stress treated group rats (G2) showed variable increase in serum Total protein, Total cholesterol, Triglycerides, Glucose, ALT, and ALP levels. Administration of ethanolic extracts of Aerva lanata linn., flower significantly prevented immobilisation stress induced elevation in the levels of serum diagnostic enzymes alanine amino transferase (ALT) and alkaline phosphatase (ALP), levels in experimental groups of rats. Moreover, total protein levels were significantly increased in treatment groups. The effect of extract was compared with a standard drug (Ranitidine). The changes in biochemical parameters were supported by histological profile. It is concluded that the ethanolic extract of Aerva lanata flower protects against immobilisation stress induced gastric ulcers in rats. In the present study treatment with Aerva lanata flower extract significantly decreased the elevated levels of Glucose, ALT, ALP, Triglyserides, glucose and increased the levels of Total proteins. From the results indicated that the ulcer protective activity of Aerva lanata flower may be due to the presence of several biochemical compounds. It is thus apparent that Aerva lanata possesses an ulcer protective activity.

TO DEVELOP AND VALIDATE UV-SPECTROSCOPIC METHOD FOR THE ESTIMATION OF ?-LIPOIC ACID AND L-GLUTATHIONE REDUCED USING METHYLENE BLUE AS A DERIVATIZING AGENT

Pooja. D Dhruv*, Parula. B Patel*
S. J. Thakkar Pharmacy College, Opp. Seasons Hotel, Near N.R.I. Bunglows, Avadh Road, Kalawad Road, Rajkot-360005, Gujarat, India.

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FOURIER TRANSFORM-INFRARED SPECTROSCOPIC STUDIES ON EDIBLE Punica granatum FLOWERS

Suja Pandian. R*, Yuvaranjani .V
Department of Biochemistry, Rabiammal Ahamed Maideen College for Women, Tiruvarur, Tamil Nadu, India.

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DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING REVERSED-PHASE LIQUID CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND CANAGLIFLOZIN IN PRESENCE OF THEIR DEGRADATION PRODUCTS

Nidhi Kotecha^*1,2,3, Jayvadan Patel^2,3
¹University of Colorado, Anschutz medical campus, Denver, USA – 80045.
²Gujarat Technological University, Ahmedabad, Gujarat, India.
³Nootan Pharmacy College, Visnagar, Gujarat, India.

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DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN AND CANAGLIFLOZIN IN BULK AND COMBINED DOSAGE FORM

Nidhi Kotecha^1,2, Jayvadan Patel^2,3
¹University of Colorado, Anschutz medical Campus, Denver, USA – 80045.
²Gujarat Technological University, Ahmedabad, Gujarat, India.
³Nootan Pharmacy College, Visnagar, Gujarat, India.

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DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR ESTIMATION OF ARGATROBAN IN BULK AND IN PHARMACEUTICAL DOSAGE FORM

Varsha Rajkumar Jamakhandi, Dr. M.S. Kalshetti, Prof. R.Y. Patil
Department of Quality Assurance, College of Pharmacy, Solapur, Maharashtra, India.

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SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL INDOLIZINE DERIVATIVES

Basavaraj M^1*, Giles D², Das AK², Sakharam AG²
¹Vivekananda college of Pharmacy, Rajajinagar, Bengaluru-55.
²Acharya and BM Reddy College of Pharmacy, Bengaluru-107.

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FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF MONTELUKAST SODIUM

Chamanpreet Kaur*, Sandeep Kumar
A.S.B.A.S.J.S. Memorial College of Pharmacy, Affiliated to I.K Gujral Punjab Technical University, Bela (Ropar), Punjab, India. Pin- 140111.

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STANDARDIZATION AND PHYSICOCHEMICAL INVESTIGATION OF TRIPHALA CHURNA

Sweta Kulkarni*, Deepika Bairagee, Neetu Choudhary
School of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore-452001, M.P.

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PRELIMINARY PHYTOCHEMICAL AND GC MS STUDY OF ONE MEDICINAL PLANT CARISSASPINARUM

Mudiganti Ram Krishna Rao^1*, Anisha G¹

Bharath Institute of Higher Eduction and Research, Bharath University, Chennai, 600 073, India.

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