Welcome to Indo American Journal of Pharmaceutical Research

JANUARY 2018

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ANTIVIRAL DRUGS, GRAZOPREVIR AND ELBASVIR, SIMULTANEOUSLY IN BULK AND IN TABLETS

Pallapati Suman^1,2*, Tirukkovalluri Siva Rao¹, Kallam Venkata Siva Rama Krishna Reddy²
¹Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India - 530003.
²Laurus Labs Limited, Visakhapatnam, Andhra Pradesh, India - 531021.

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AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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CLINICAL PHARMACIST IS KEY ROLE OF THE PATIENT-CENTERED CARE IN TERTIARY CARE TEACHING HOSPITALS IN INDIAN SENERIO

Venkata Ramarao Nallani^*1, Prof.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, PAHER University, Udaipur.

⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

HISTAMINE RECEPTORS IN CENTRAL NERVOUS SYSTEM

Nishant S. Jain*

Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur-495009 (C.G.), India

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EVALUATION OF ANTHELMINTIC ACTION OF EMBLICA OFFICINALIS LEAVES EXTRACT ON INDIAN EARTH WORM

Tanvi T. Sambre *1, Tushar K. Sambre 1, Shivprasad H. Majumdar 2

1Priyadarshani Yashodhara College of Pharmacy Chandrapur, Bangali Camp Mul Road Chandrapur.

2Satara College of Pharmacy, Satara.

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BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF NIRAPARIB IN PLASMA SAMPLES BY LC-MS/MS

Vamseekrishna Gorijavolu*1,2, Ajay Kumar Gupta1, Y.A.Chowdary2 , Raviteja .B3

1Institute of Pharmacy, C.S.J.M University, Kanpur,uttar pradesh , India.

2NRI College of Pharmacy, pothavarappadu, Andhrapradesh, India.

3M.A.M College of Pharmacy, Narasarao pet, Andhrapradesh, India.

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PHARMACOECONOMIC EVALUATION ON COST EFFECTIVE ANALYSIS OF ORAL HYPOGLYCAEMIC AGENTS IN A SOUTH INDIAN TERTIARY CARE TEACHING HOSPITAL

Thampi Anna Ammu, Vijayan Chippy, Ansel Dona, Shibu Sara Shilpa, Sushilkumar.P. Londhe*

Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

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Diabetes Mellitus is "A metabolic disorder characterized by hyperglycaemia resulting from defects in insulin secretion or insulin action or both". "Pharmacoeconomic analysis compares two or more medication options or strategies in terms of their cost and outcome or benefit".The objective of the study is to assess cost effective analysis of oral hypoglycaemic agents on the therapy of patients suffering from Type 2 DM[diabetes mellitus].A prospective observational study was conducted for a period of 6 months in the general medicine OPD[outpatient department] of SSIMS & RC[shammanur shivashankarappa instituteof medical science and research center]. Out-patients who were diagnosed with type 2 diabetes mellitus and receiving treatment specifically with oral hypoglycaemic agents were included in the study. After obtaining the approval from institutional ethical committee, a structured data collection form was developed to collect demographic datas, complete prescription details and other informations required in the study. Among all oral hypoglycaemic agents the most effective drug/combination in the region was identified.A total of 100 case records were identified and assessed in which 59% were males and 41% were females. Maximum number of patients with type 2 DM were from age group of 50-59 years followed by the age group of 40-49 years and then from 60-69 years.Metformin showed a highest difference in the FBS[fasting blood sugar] value of 4.30 mg/dl, while in combinational therapy Metformin + Glimepiride showed a highest difference in the FBS value of 5.94 mg/dl.In single anti-diabetic therapy, Glibenclamide showed a highest cost difference with 1233.2%, in combinational therapy Metformin + Glimepiride showed a maximum cost difference of 194.18%.Analysis of prescription data found that the single most commonly prescribed drug was Metformin and the most common combination used was Metformin + Glimepiride. Metformin alone and Metformin + Glimepiride showed maximum efficacy in control of glucose level. Glibenclamide alone and Metformin + Glimepiride showed most cost effectiveness.

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Diabetes Mellitus is "A metabolic disorder characterized by hyperglycaemia resulting from defects in insulin secretion or insulin action or both". "Pharmacoeconomic analysis compares two or more medication options or strategies in terms of their cost and outcome or benefit".The objective of the study is to assess cost effective analysis of oral hypoglycaemic agents on the therapy of patients suffering from Type 2 DM[diabetes mellitus].A prospective observational study was conducted for a period of 6 months in the general medicine OPD[outpatient department] of SSIMS & RC[shammanur shivashankarappa instituteof medical science and research center]. Out-patients who were diagnosed with type 2 diabetes mellitus and receiving treatment specifically with oral hypoglycaemic agents were included in the study. After obtaining the approval from institutional ethical committee, a structured data collection form was developed to collect demographic datas, complete prescription details and other informations required in the study. Among all oral hypoglycaemic agents the most effective drug/combination in the region was identified.A total of 100 case records were identified and assessed in which 59% were males and 41% were females. Maximum number of patients with type 2 DM were from age group of 50-59 years followed by the age group of 40-49 years and then from 60-69 years.Metformin showed a highest difference in the FBS[fasting blood sugar] value of 4.30 mg/dl, while in combinational therapy Metformin + Glimepiride showed a highest difference in the FBS value of 5.94 mg/dl.In single anti-diabetic therapy, Glibenclamide showed a highest cost difference with 1233.2%, in combinational therapy Metformin + Glimepiride showed a maximum cost difference of 194.18%.Analysis of prescription data found that the single most commonly prescribed drug was Metformin and the most common combination used was Metformin + Glimepiride. Metformin alone and Metformin + Glimepiride showed maximum efficacy in control of glucose level. Glibenclamide alone and Metformin + Glimepiride showed most cost effectiveness.

SOLUBILITY ENHANCEMENT OF DIACEREIN BY SOLID DISPERSION TECHNIQUES

Devidas Gulabrao Bachhav*1, Somashekhar S.Khadabadi2

1M.G.V.�s S.P.H.College of Pharmacy, Malegaon, Nashik (MS), India.

2Government College of Pharmacy, Amravati, (MS), India.

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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ELIGLUSTAT USING RP-HPLC METHOD IN BULK AND PHARMACEUTICAL DOSAGE FORM

Amena Tazeen1*, Dr. R. Vani2, Dr. M. Sunitha3

1Department of Pharmaceutical Analysis and Quality Assurance, Shadan Women�s College Pharmacy, Hyderabad, India.

2Department of Pharmaceutical Analysis, Shadan Women�s College Pharmacy, Hyderabad, India.

3Principal of Shadan Women�s College Pharmacy, Hyderabad, India.

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A STUDY TO ASSESS THE UTILIZATION PATTERN OF ANTIBIOTICS FOR THE TREATMENT OF LOWER RESPIRATORY TRACT INFECTION IN THE PEDIATRIC DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL

Mathew Rose Anie, Joseph Mary Navitha, Johnson Seena, J.Muneerudeen.*

Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

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Drug utilization research was defined by WHO in 1977 as the "marketing, distribution, prescription and the use of drugs in the society with special emphasis on the resulting medical, social and economic consequences". Drug utilization plays a significant role in helping the health-care system to understand, interpret and improve the prescribing administration and use of medications. Drug utilization research provides insight to different aspects of drug use and drug prescribing such as pattern of use, quality of use and outcomes of drug use. The objective of this study is to assess the prescribing and utilization pattern of antibiotics prescribed to the patients with LRTI admitted in Pediatric Department. A Prospective observational study was conducted for a period of 6 months. Ethical clearance was obtained from the Institutional Ethical Committee of Bapuji Pharmacy College, Davangere. Data of pediatric patients collected from the Pediatric ward were included in the study. The collected data was analyzed using Microsoft excel. The DDD/1000 inhabitants/day was also calculated. The medication order problem like possible drug-drug interaction is also evaluated. In our study a total of 150 patients were enrolled. Out of the 150 cases, 88patients (58.67%) were males and 62 patients (41.33%) were females. Pneumonia cases (97) were found to be more when compared to all other forms of LRTI.The most commonly found associated illness was anaemia.The average number of antibiotics per prescription was 1.23 and the average hospital stay was 5.7±2.3 days. The mostly prescribed antibiotic was Amoxicillin followed by Ceftriaxone. Most of the drugs were prescribed through parenteral route. That is, 96.22% of the drugs were prescribed through parenteral route and 3.78% were prescribed through oral route. Out of the 150 cases only 14 cases were subjected for performing culture sensitivity test. In our study, a total of 38 interactions were found. In that 4 major, 9 moderate and 25 minor interactions were found. The PDD and DDD of the antibiotics were also compared. Drug utilization studies have the potential to make objective evaluation and analysis of health professionals work and provide them with feedback to stimulate thinking about their practice and looking for ways to improve their own performance. These studies should become a method of increasing job satisfaction and means of education for health professionals, rather than being perceived as threat or another bureaucratic burden.

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Drug utilization research was defined by WHO in 1977 as the "marketing, distribution, prescription and the use of drugs in the society with special emphasis on the resulting medical, social and economic consequences". Drug utilization plays a significant role in helping the health-care system to understand, interpret and improve the prescribing administration and use of medications. Drug utilization research provides insight to different aspects of drug use and drug prescribing such as pattern of use, quality of use and outcomes of drug use. The objective of this study is to assess the prescribing and utilization pattern of antibiotics prescribed to the patients with LRTI admitted in Pediatric Department. A Prospective observational study was conducted for a period of 6 months. Ethical clearance was obtained from the Institutional Ethical Committee of Bapuji Pharmacy College, Davangere. Data of pediatric patients collected from the Pediatric ward were included in the study. The collected data was analyzed using Microsoft excel. The DDD/1000 inhabitants/day was also calculated. The medication order problem like possible drug-drug interaction is also evaluated. In our study a total of 150 patients were enrolled. Out of the 150 cases, 88patients (58.67%) were males and 62 patients (41.33%) were females. Pneumonia cases (97) were found to be more when compared to all other forms of LRTI.The most commonly found associated illness was anaemia.The average number of antibiotics per prescription was 1.23 and the average hospital stay was 5.7±2.3 days. The mostly prescribed antibiotic was Amoxicillin followed by Ceftriaxone. Most of the drugs were prescribed through parenteral route. That is, 96.22% of the drugs were prescribed through parenteral route and 3.78% were prescribed through oral route. Out of the 150 cases only 14 cases were subjected for performing culture sensitivity test. In our study, a total of 38 interactions were found. In that 4 major, 9 moderate and 25 minor interactions were found. The PDD and DDD of the antibiotics were also compared. Drug utilization studies have the potential to make objective evaluation and analysis of health professionals work and provide them with feedback to stimulate thinking about their practice and looking for ways to improve their own performance. These studies should become a method of increasing job satisfaction and means of education for health professionals, rather than being perceived as threat or another bureaucratic burden.

EVALUATION OF IN VIVO NEUROPROTECTIVE EFFECT OF ROOT OF CLITORIA TERNATIA AGAINST ETHIDIUM BROMIDE INDUCED DEMYELINATION RAT MODEL.

G. Neelamma1*, B. Duraiswamy1, Nehru Sai Suresh1, Ch. Vadivelan2, R. Sandhya2, Ch. Justin2

1Department of Pharmacognosy and Phytopharmacy, JSS College of Pharmacy, Ooty, Tamilnadu.

2Department of Pharmacology, JSS College of Pharmacy, Ooty, Tamilnadu.

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TOP DANGEROUS DRUG INTERACTIONS IN LONG TERM CARE AND THEIR MECHANISM, PREVENTION, MANAGEMENT

Dr.Gummalla Pitchaiah*1, Dr. D. Dachinamoorthi2, Dr. SK. Firoz1, Dr. Gaddam Chandrika1, Dr. M. Jyosthna Sri1, Dr. Nalluri Kranthi Koushik1

1Department of Pharmacy Practice, QIS College of Pharmacy, Vengamukkapalem, Ongole, India- 523 272.

2Department of Pharmaceutics, QIS College of Pharmacy, Vengamukkapalem, Ongole, India- 523 272.

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DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF VALSARTAN AND SACUBITRIL IN TABLET DOSAGE FORM

M.Madan Mohan Reddy1*, D.Gowri Sankar2, JVLN Seshagiri Rao2

1Eisai Pharmaceuticals India Pvt.Ltd, Ramky Pharma City(SEZ), Parawada, Visakhapatnam, Andhra Pradesh, India-531019.

2College of Pharmaceutical Sciences, Visakhapatnam, Andhra University, Andhra Pradesh, India- 530003.

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SOLUBILITY ENHANCEMENT TECHNIQUES SOLUTIONS TO SOLUBILITY PROBLEM

Shaikh Siraj Nawaj*, Saleem Mau Patel, G. J. Khan, Patel M Siddik

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India.

Ali-Allana College of pharmacy Akkalkuwa Dist, Nandurbar, Maharashtra, India.

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HYPROMELLOSE AND CARBOMER INDUCE BIOADHESION OF ACYCLOVIR TABLET TO VAGINAL MUCOSA

Nilesh M. Mahajan*, Ankit Pardeshi, Debarshi Kar Mahapatra, Arti J. Darode, Nitin G. Dumore

Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra, India.

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COMPARATIVE INVESTIGATION OF ANTIDIABETIC ACTIVITY OF ACARBOSE, MIGLITOL AND SALACIA OBOLNGA IN PATIENTS OF TYPE 2 DIABETES MELLITUS

Amol D. Landge*, Chaitali. R. Pawar2, Vishal S Lad1, Vijay. M. Sastry1, Prakash. R. Gade3

Gangamai College of Pharmacy Nagaon, Dhule 424001 (Maharashtra).

Government Polytechnic Jalgaon 425001 (Maharashtra). Maharashtra Institute of Medical Sciences and Research Latur 413 531 (Maharashtra).

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A LC-MS/MS METHOD FOR THE QUANTIFICATION OF CLAVULANATE IN HUMAN PLASMA BY NEGATIVE ION MODE AND ITS PHARMACOKINETIC APPLICATION

V.Satish Ramanatham*1,2, P.Venkateswarlu3

*1Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana State, India.

2Anacipher Clinical Research Organization, Ramanthapur, Hyderabad.

3Vimta Labs Limited, Cherlapally, Hyderabad-500 051, India.

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POTENTIAL ANTITUBERCULAR AND SAR STUDY OF SUBSTITUTED [2-(1-BENZOFURAN-2-YL) QUINOLIN-4-YL] METHANOL AND [2-(1-FURAN-2-YL) QUINOLIN-4-YL] METHANOL ANALOGUES

N. D. Satyanarayan*, Anantacharya R.

Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Centre, Kadur-577548, Chikkamagaluru Dt., Karnataka St. India.

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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF VILDAGLIPTIN IN BULK AND ITS DOSAGE FORM USING UV SPECTROPHOTOMETER

P. V. Prasad*, K. Divya, M.V. Ramana, A. Krishnaveni, J. Vinay, M. Mahadeswar

SVU College of Pharmaceutical Sciences, Sri Venkateswara University, Tirupati � 517502, Andhra Pradesh, India.

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IDENTIFICATION, ASSESSMENT AND ANALYSIS OF SUSPECTED ADVERSE DRUG REACTIONS IN A TERTIARY CARE TEACHING HOSPITAL AT SSIMS & RC, DAVANGERE

Theresa Anu, J Anusree, Jacob Merin, Londhe P Sushilkumar

Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

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PREPARATION AND EVALUATION OF ANTI HYPERTENSIVE IR GRANULES AND ANTI DIABETIC SR MINI TABLETS FILLED CAPSULE SYSTEMS

Dr. M. SUNITHA REDDY*, GUDUGUNTLA SRILATHA, S. MUHAMMAD FAZAL UL HAQ

CPS, IST, JNTUH.

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CORRELATION BETWEEN SERUM ZINC, INSULIN AND C-PEPTIDE IN PATIENTS OF TYPE 2 DM IN A TERTIARY HOSPITAL IN NORTH INDIA

Obaid M*1, Agrawal BK2

1Department of Biochemistry, Government Medical College, Srinagar, J&K, India.

2Department of General Medicine, MMIMSR, Mullana, Ambala, Haryana, India.

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A STUDY TO IDENTIFY, ASSESS AND EVALUATE THE INCIDENCE OF INTENTIONAL AND UNINTENTIONAL ORGANOPHOSPHOROUS POISONING IN A SOUTH INDIAN TERTIARY CARE TEACHING HOSPITAL AT DAVANGERE, KARNATAKA

Pious Mary Ann, T.J. Aparna, T.S. Reshma, Sam Shency, Sam .K. Gloria*.

Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

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PREPARATION AND EVALUATION OF IN SITU GELLING MICONAZOLE NITRATE LIQUID VAGINAL SUPPOSITORY

Ramandeep Kaur*, Sandeep Kumar, Ghanshyam Das Gupta

A.S.B.A.S.J.S. Memorial College of Pharmacy, Affiliated to I.K Gujral Punjab Technical University, Bela (Ropar), Punjab, India. Pin- 140111.

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DESIGN AND DEVELOPMENT OF SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF LURASIDONE HCl

Komal Rahevar*, Dr. Mukesh R. Patel, Dr. Kanu R. Patel

Gujarat Technological University, Gujarat.

Shri B. M. Shah College of Pharmaceutical Education and Research, College Campus, Dhansura Road, Modasa- 383 315. (Arvalli) Gujarat, India.

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IDENTIFICATION AND EVALUATION OF DRUG RELATED PROBLEMS AND ITS PREVALENCE IN MEDICAL AND EMERGENCY WARD OF ATERTIARY CARE TEACHING HOSPITAL

D.Amrutha, Johnson Feba, Mathew Nissy, Sam.K.Gloria*

Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

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