Welcome to Indo American Journal of Pharmaceutical Research

FEBRUARY 2018

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ANTIVIRAL DRUGS, GRAZOPREVIR AND ELBASVIR, SIMULTANEOUSLY IN BULK AND IN TABLETS

Pallapati Suman^1,2*, Tirukkovalluri Siva Rao¹, Kallam Venkata Siva Rama Krishna Reddy²
¹Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India - 530003.
²Laurus Labs Limited, Visakhapatnam, Andhra Pradesh, India - 531021.

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AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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CLINICAL PHARMACIST IS KEY ROLE OF THE PATIENT-CENTERED CARE IN TERTIARY CARE TEACHING HOSPITALS IN INDIAN SENERIO

Venkata Ramarao Nallani^*1, Prof.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, PAHER University, Udaipur.

⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

HYPERTENSION: CAUSES AND PHARMACEUTICAL ISSUES

Devi Rajni*, Kumar Sandeep
Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab -140111, INDIA.

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FORMULATION AND EVALUATION OF HYDROGEL CONTAINING AZITHROMYCIN AND SILVER NANOPARTICLES

Shubhangi S. Kharat*, Vishal D. Yadav, Prakash D. Jadhav, Ganesh D. Mote
Department of Pharmaceutics and Pharmaceutical Chemistry, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharashtra (India) 415004.

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The main aim of the study is to formulate and evaluate hydrogel containing azithromycin and silver nanoparticles to treat wound dressing, burn infections, acne, Pharyngitis and Tonsillitis, psoriasis, etc. The Silver nanoparticles were prepared by green synthesis approach with the help of reduction of silver nitrate by Azadirachta indica leaves extract. Azithromycin was chosen as antimicrobial drug, however it shows adverse effect when administered in high dose, hence to reduce dose of azithromycin it was decided to make formulation containing silver nanoparticles and azithromycin. The drug loading and drug delivery techniques were searched for topical as well as bone grafting purpose. Initially mixing of Silver nanoparticles, Azithromycin and Bis acrylamide in ammonium persulphate were done and added N, N dimethyl amino ethyl methacrylate (DEM) to form semisolid mass that is hydrogel. Hydrogel formulation was found fantastic results with azithromycin and silver nanoparticles. The compatibility study was done for silver nanoparticles with polymer and azithromycin and all are found compatible with each other. All the formulations were characterized for consistency, spreadability, efficacy, safety and stability. From all F1-F12 Hydrogel Formulations F4 batch was optimized by parameters like pH measurement, spreadability, Drug content, Drug release and antimicrobial assay. So F4 batch was further evaluated for SEM, XRD, FTIR, skin Irritation study and showed good results. Hydrogel formulation of azithromycin and silver nanoparticles formulated for Azithromycin as a antimicrobial drug, however it shows adverse effect when administered in high dose, hence to reduce dose of azithromycin it was decided to make formulation containing silver nanoparticles and azithromycin. It was concluded that formulation was compatible with animal as well as human being with excellent evaluation results.

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The main aim of the study is to formulate and evaluate hydrogel containing azithromycin and silver nanoparticles to treat wound dressing, burn infections, acne, Pharyngitis and Tonsillitis, psoriasis, etc. The Silver nanoparticles were prepared by green synthesis approach with the help of reduction of silver nitrate by Azadirachta indica leaves extract. Azithromycin was chosen as antimicrobial drug, however it shows adverse effect when administered in high dose, hence to reduce dose of azithromycin it was decided to make formulation containing silver nanoparticles and azithromycin. The drug loading and drug delivery techniques were searched for topical as well as bone grafting purpose. Initially mixing of Silver nanoparticles, Azithromycin and Bis acrylamide in ammonium persulphate were done and added N, N dimethyl amino ethyl methacrylate (DEM) to form semisolid mass that is hydrogel. Hydrogel formulation was found fantastic results with azithromycin and silver nanoparticles. The compatibility study was done for silver nanoparticles with polymer and azithromycin and all are found compatible with each other. All the formulations were characterized for consistency, spreadability, efficacy, safety and stability. From all F1-F12 Hydrogel Formulations F4 batch was optimized by parameters like pH measurement, spreadability, Drug content, Drug release and antimicrobial assay. So F4 batch was further evaluated for SEM, XRD, FTIR, skin Irritation study and showed good results. Hydrogel formulation of azithromycin and silver nanoparticles formulated for Azithromycin as a antimicrobial drug, however it shows adverse effect when administered in high dose, hence to reduce dose of azithromycin it was decided to make formulation containing silver nanoparticles and azithromycin. It was concluded that formulation was compatible with animal as well as human being with excellent evaluation results.

A STABILITY INDICATING METHOD FOR THE SIMULTANEOUS ESTIMATION OF OFLOXACIN AND METRONIDAZOLE IN BULK AND DOSAGE FORM

Dr. Osman Ahmed*, Kauser Fathima, Syed Vakeeluddin
Department of Pharmaceutical Analysis, Deccan School of Pharmacy, Hyderabad.

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FORMULATION AND EVALUATION OF GASTRO RETENTIVE IN- SITU FLOATING GELS OF ATORVASTATIN CALCIUM CUBOSOMES

Dr. M. Sunitha Reddy*, M.Tejasri, S. Muhammad Fazal Ul Haq
Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

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FORMULATION AND EVALUATION OF HERBAL LIPSTICK CONTAINING ANTIFUNGAL AGENT

Tejashri A. Gore*, Priya Rodge
Rajarshi Shahu College of Pharmacy & Research, Pune – Mumbai Highway, Tathawade, Pune-411033, Maharashtra, India.

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FORMULATION AND EVALUATION OF 18-? GLYCYRRHETINIC ACID TRANSDERMAL PATCH FOR ANTI-SMOKING ACTIVITY

B.Bhuvana, S.Nagalakshmi*, S.Shanmuganathan, S.Nagalakshmi
Department of pharmaceutics, Sri Ramachandra University, Chennai.

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FREQUENCY OF DIASTOLIC HEART FAILURE AND ITS COMMON FACTORS IN PATIENTS WITH NEW ONSET HEART FAILURE

Dr. Syed Dawood Shah, Dr. Hazrat Ali, Dr. Noor Ahmed Khosa, Dr. Syed Abdul Bari, Dr. Sheikh Ahmed, Dr. Muhammad Samsoor Zarak, Mir Zaman Kasi

Sandeman Provincial Hospital Quetta, Balochistan Pakistan.

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Heart failure with preserved ejection fraction is the clinical syndrome of heart failure associated with normal or near normal systolic function. Ppatients who have heart failure present with dyspnea, orthopnea, paroxysmal nocturnal dyspnea and exercise intolerance, regardless of a preserved or an impaired ejection fraction. Diastolic dysfunction is the most important pathophysiological mechanism ultimately leading diastolic heart failure. Abnormal cardiomyocyte sodium and calcium handling within myocytes has been proposed as a potential mechanism that contributes to diastolic dysfunction. Risk factors for diastolic dysfunction are older age, female sex, hypertension, ischemia, obesity and coronary artery disease. The rates of death and illness among these patients are high and have not declined, as they have in patients with heart failure and a low left ventricular ejection fraction. The objective of this study is to determine the frequency of diastolic heart failure and its common factors in patients with new onset heart failure. This study was conducted at Bolan Medical College / SPH, Department of Cardiology, Hospital, Quetta. Study design was descriptive cross sectional study and the duration of the study was one years (2012-2013). The total sample size was 205 using 7%12 proportion of heart failure among general population, 95% confidence interval and 3.5% margin of error under WHO sample size calculation. More over non probability purposive sampling technique was used for sample collection. All patients both male and female of age more than 20 years admitted to Cardiology Unit with signs and symptoms of heart failure were included while patients having prior history of diagnosed heart failure and on treatment, patients having prior history of coronary artery disease, patients with acute pericarditis, acute myocarditis and unstable angina were excluded. In this study 4% patients were in age range 40-50 years, 28% patients were in age range 51-60 years, 35% patients were in age range 61-70 years and 33% patients were in age range 71-80 years. Mean age was 65 years with SD ± 1.26. Forty five percent patients were male and 55% patients were female. The frequency of diastolic heart failure was 8% in patients with new onset heart failure in which 60% patients were female gender, 70% patients had hypertension, 11% patients had atrial fibrillation. Our study conclude that the incidence of diastolic heart failure was 8% in patients with new onset heart failure in which 60% patients were female gender, 70% patients had hypertension, 11% patients had atrial fibrillation. Which shows that hypertension and gender in onset of diastolic heart failure was found to be an independent predictor of mortality.

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Heart failure with preserved ejection fraction is the clinical syndrome of heart failure associated with normal or near normal systolic function. Ppatients who have heart failure present with dyspnea, orthopnea, paroxysmal nocturnal dyspnea and exercise intolerance, regardless of a preserved or an impaired ejection fraction. Diastolic dysfunction is the most important pathophysiological mechanism ultimately leading diastolic heart failure. Abnormal cardiomyocyte sodium and calcium handling within myocytes has been proposed as a potential mechanism that contributes to diastolic dysfunction. Risk factors for diastolic dysfunction are older age, female sex, hypertension, ischemia, obesity and coronary artery disease. The rates of death and illness among these patients are high and have not declined, as they have in patients with heart failure and a low left ventricular ejection fraction. The objective of this study is to determine the frequency of diastolic heart failure and its common factors in patients with new onset heart failure. This study was conducted at Bolan Medical College / SPH, Department of Cardiology, Hospital, Quetta. Study design was descriptive cross sectional study and the duration of the study was one years (2012-2013). The total sample size was 205 using 7%12 proportion of heart failure among general population, 95% confidence interval and 3.5% margin of error under WHO sample size calculation. More over non probability purposive sampling technique was used for sample collection. All patients both male and female of age more than 20 years admitted to Cardiology Unit with signs and symptoms of heart failure were included while patients having prior history of diagnosed heart failure and on treatment, patients having prior history of coronary artery disease, patients with acute pericarditis, acute myocarditis and unstable angina were excluded. In this study 4% patients were in age range 40-50 years, 28% patients were in age range 51-60 years, 35% patients were in age range 61-70 years and 33% patients were in age range 71-80 years. Mean age was 65 years with SD ± 1.26. Forty five percent patients were male and 55% patients were female. The frequency of diastolic heart failure was 8% in patients with new onset heart failure in which 60% patients were female gender, 70% patients had hypertension, 11% patients had atrial fibrillation. Our study conclude that the incidence of diastolic heart failure was 8% in patients with new onset heart failure in which 60% patients were female gender, 70% patients had hypertension, 11% patients had atrial fibrillation. Which shows that hypertension and gender in onset of diastolic heart failure was found to be an independent predictor of mortality.

IN VITRO INHIBITORY EFFECTS OF MUCUNA PRURIENS AND VETIVERIA ZIZANOIDES ON SELECTED HUMAN BACTERIAL PATHOGENS

S.Selva Kumar*, Mudiganti Ram Krishna Rao, Saintani Choudhury
Department of Industrial Biotechnology, Bharath University, Chennai, 600073. India.

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PRELIMINARY PHYTOCHEMICAL INVESTIGATION OF VARIOUS EXTRACTS OF LEAVES OF KLEINIA GRANDIFLORA

S. Selvakumar*
Department of Industrial BioTechnology, Bharath University, Chennai-600073, India.

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DETERMINATION OF BIO ACTIVE COMPOUNDS OF A POLY HERBAL FORMULATION ACTP BY GC MS ANALYSIS

S. Selvakumar*, R. Valliammai
Department of Industrial Biotechnology, Bharath University, Chennai-600073, India.

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PHYTOCHEMICAL PROFILE OF VARIOUS EXTRACTS OF INDIGOFERA ASPALATHOIDES

S. Selvakumar*
Department of Industrial Biotechnology, Bharath University, Chennai-600073, India.

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EXTRACTION AND CHARACTERIZATION OF MUCILAGES FROM FRUITS OF CORDIA LATIFOLIA AND AEGLE MARMELOS FOR ITS MUCOADHESIVE BEHAVIOUR

Patil N. D.¹, Marathe R. P.², Patil K.S.^*1
¹Government College of Pharmacy, Kathora Naka, Amravati, Maharashtra- 444604, India.
₂Government College of Pharmacy, Aurangabad, Maharashtra-431005, India.

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FORMULATION AND EVALUATION OF TACROLIMUS LOADED LIQUID CRYSTALLINE NANOPARTICLES

Hiren Kodinariya*, Chintan Aundhia, Avinash Seth, Nirmal Shah, Vinod Ramani, Snehal Patel, Dipti Gohil
*Deparatment of Pharmacy, Sumandeep Vidyapeeth, Vadodara.

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The use of liquid crystalline nanoparticles is a novel approach in the field of controlled drug delivery. Tacrolimus, being a highly lipophilic drug, is easily incorporated in the hydrophobic core of these nanoparticles. Which are prepare by pseudo binary mixture technique by using polymers like monoolein and poloxomer 407 to extend the drug release for about 32 hours, there by improved bioavailability. Formulation optimization of tacrolimus loaded liquid crystalline nanoparticles was carried out by using different concentration of monoolein and poloxomer 407. Total 10 batches were formulated. The process optimization was carried out at three different stirring speeds i.e. 2200, 2500 and 2800 rpm for three different stirring time period i.e. 05mins, 10mins and 15mins. Out of all the batches S5 showed the spherical shape of liquid crystalline nanoparticles. All 10 batches were evaluated for entrapment efficiency (EE) and particle size (nm). Among all batches S5 shows maximum entrapment efficiency (EE) and uniform particle size and was considered as optimized formulation. Optimized batch S5 was evaluated for Zeta Potential, Particle Size Distribution which show -35.4mV and 126.1nm particle size, TEM Analysis. Batch S5 was charged for stability and were placed in glass vials container and stored at ICH storage condition (30 ± 2°C / 60% ± 5% RH , 40 ± 2°C / 75% ± 5% RH ) for a period of 30 days. The samples were analyzed for physical appearance, entrapment efficiency and particle size after 30 days. After 1 months samples were withdrawn and liquid crystalline nanoparticles showed no change in physical appearances, entrapment efficiency and particle size, which indicate that the liquid crystalline nanoparticles were stable. Therefore, study suggests the possible use of tacrolimus-loaded formulation for intradermal or topically delivery can be useful in the treatment of locally affecting autoimmune skin disease such as psoriasis.

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The use of liquid crystalline nanoparticles is a novel approach in the field of controlled drug delivery. Tacrolimus, being a highly lipophilic drug, is easily incorporated in the hydrophobic core of these nanoparticles. Which are prepare by pseudo binary mixture technique by using polymers like monoolein and poloxomer 407 to extend the drug release for about 32 hours, there by improved bioavailability. Formulation optimization of tacrolimus loaded liquid crystalline nanoparticles was carried out by using different concentration of monoolein and poloxomer 407. Total 10 batches were formulated. The process optimization was carried out at three different stirring speeds i.e. 2200, 2500 and 2800 rpm for three different stirring time period i.e. 05mins, 10mins and 15mins. Out of all the batches S5 showed the spherical shape of liquid crystalline nanoparticles. All 10 batches were evaluated for entrapment efficiency (EE) and particle size (nm). Among all batches S5 shows maximum entrapment efficiency (EE) and uniform particle size and was considered as optimized formulation. Optimized batch S5 was evaluated for Zeta Potential, Particle Size Distribution which show -35.4mV and 126.1nm particle size, TEM Analysis. Batch S5 was charged for stability and were placed in glass vials container and stored at ICH storage condition (30 ± 2°C / 60% ± 5% RH , 40 ± 2°C / 75% ± 5% RH ) for a period of 30 days. The samples were analyzed for physical appearance, entrapment efficiency and particle size after 30 days. After 1 months samples were withdrawn and liquid crystalline nanoparticles showed no change in physical appearances, entrapment efficiency and particle size, which indicate that the liquid crystalline nanoparticles were stable. Therefore, study suggests the possible use of tacrolimus-loaded formulation for intradermal or topically delivery can be useful in the treatment of locally affecting autoimmune skin disease such as psoriasis.

DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LAMIVUDINE AND DOLUTEGRAVIR IN DRUG PRODUCT BY RP-HPLC

B.Sowjanya^1*, Dr.K.Rambabu²
R V R & J C College of Engineering, Chowdavaram, Guntur, Andhra Pradesh – 522019.

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DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DACLATASVIR AND SOFOSBUVIR IN DRUG PRODUCT BY RP-HPLC

M. Srinivasa Rao*, Dr. K. Rambabu
Department of Chemistry, R V R & J C College of Engineering, Chowdavaram, Guntur, Andhra Pradesh – 522019.

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PREVALENCE OF MENTAL RETARDATION IN CHILDREN WITH ADHD, AN EPIDEMIOLOGICAL STUDY, AT SIR C.J.INSTITUTE OF PSYCHIATRY, HYDERABAD

Dr.Syed Qalb-I-Hyder Naqvi¹, Asra Qureshi², Prof; Moin Ahmed Ansari³, Dr.Saleem Uddin Rashed⁴, Dr.Zulfiqar Siddiqui⁵, Dr.Summaira Channa⁶, Dr.S.Nisar Ahmed⁷
¹Sir. Cowas Jee Institute Of Psychiatry Hyderabad.

²Department of Medicine (Cardiology), Faculty of Health Sciences, Medical College.

³The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan.
⁴Chairman Department of Psychiatry LUMHS Jamshoro.

⁵Muhammad Medical College Mirpur khas.

⁶Sir.C.J.Institute of Psychiatry.

⁷Sir. Cowas Jee Institute Of Psychiatry Hyderabad.

⁸District Headquater Hospital Matyari.

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FLOATING DRUG DELIVERY SYSTEMS: AN ALTERNATIVE APPROACH TO ENHANCE GASTRIC RESIDENCE TIME

R. Santosh Kumar, Ganesh Sai Myneni
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam-45.

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ROLE OF HYDROPHILIC POLYMERS ON THE STABILITY OF FORMULATIONS OF TENOXICAM SBE7-?-CD INCLUSION COMPLEX

Venkat Ramesh, Fasiha Shah, Omar Sarheed, Shahnaz Usman, Hemant Yadav and Quamrul Islam
Department of Pharmaceutics, RAK Medical & Health Sciences University, Ras Al Khaimah , United Arab Emirates.

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IN VITRO ANTIOXIDANT POTENCY STUDIES OF HYDRO ALCOHOLIC LEAF EXTRACT OF CASSIA UNIFLORA

Sujatha Jadi¹, Pratap Kumar Patra*, Anusha Sami Reddy²
¹St. Paul College of Pharmacy, Turkayamjal, Hyderabad, R.R. Dist.
²Mother Teresa Pharmacy College, Sathupally, Hyderabad.
*Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, Hyderabad, 501510.

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CHRONOTHERAPEUTICS: CIRCADIAN RHYTHM BASED THERAPY

R.Santosh Kumar, Mangesh Pradeep Kulkarni
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam-45.

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FAST DISSOLVING DRUG DELIVERY SYSTEMS: A NOVEL APPROACH FOR ENHANCED THERAPEUTIC ACTION

R.Santosh Kumar, Poluri Sesha Sai Kiran, Mangesh Pradeep Kulkarni
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam-45.

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DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF PARITAPREVIR, RITONAVIR AND OMBITASVIR IN FIXED TABLET DOSAGE FORM

Marakada Sridevi¹, T. Siva Rao^1*, Challa Gangu Naidu²
¹School of Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India – 530 003.
²Vignan's Foundation for Science, Technology & Research University (VFSTRU), Vadlamudi, Guntur, Andhra Pradesh 522213, India.

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DEVELOPMENT OF HERBAL FORMULATION WITH AJWA SEED (Phoenix dactylifera L.) EXTRACT AND ZAM-ZAM WATER FOR ANTICANCER ACTIVITY

Ibrahim Afsal V.T^1*, B.Arul²

¹Institute of Pharmaceutical Sciences and Research Centre, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India-305004.

²Department of Pharmaceutics, Vinayaka Mission College of Pharmacy, Salem, Tamil Nadu, India.

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