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APRIL 2018

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ANTIVIRAL DRUGS, GRAZOPREVIR AND ELBASVIR, SIMULTANEOUSLY IN BULK AND IN TABLETS

Pallapati Suman^1,2*, Tirukkovalluri Siva Rao¹, Kallam Venkata Siva Rama Krishna Reddy²
¹Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India - 530003.
²Laurus Labs Limited, Visakhapatnam, Andhra Pradesh, India - 531021.

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AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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CLINICAL PHARMACIST IS KEY ROLE OF THE PATIENT-CENTERED CARE IN TERTIARY CARE TEACHING HOSPITALS IN INDIAN SENERIO

Venkata Ramarao Nallani^*1, Prof.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, PAHER University, Udaipur.

⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL INDOLIZINE DERIVATIVES

Basavaraj M^1*, Giles D², Das AK², Sakharam AG²
¹Vivekananda college of Pharmacy, Rajajinagar, Bengaluru-55.
²Acharya and BM Reddy College of Pharmacy, Bengaluru-107.

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FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF MONTELUKAST SODIUM

Chamanpreet Kaur*, Sandeep Kumar
A.S.B.A.S.J.S. Memorial College of Pharmacy, Affiliated to I.K Gujral Punjab Technical University, Bela (Ropar), Punjab, India. Pin- 140111.

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STANDARDIZATION AND PHYSICOCHEMICAL INVESTIGATION OF TRIPHALA CHURNA

Sweta Kulkarni*, Deepika Bairagee, Neetu Choudhary
School of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore-452001, M.P.

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PRELIMINARY PHYTOCHEMICAL AND GC MS STUDY OF ONE MEDICINAL PLANT CARISSASPINARUM

Mudiganti Ram Krishna Rao^1*, Anisha G¹

Bharath Institute of Higher Eduction and Research, Bharath University, Chennai, 600 073, India.

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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ARTEMETHER AND LUMEFANTRINE

R. Margret Chandira*, B. S. Venkateshwarlu, A. Pasupathi, P. Palanisamy, K. Somu
Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s University, Salem (D.T), Tamil Nadu (State), India.

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ROLE OF VARIOUS NATURAL AND SYNTHETIC POLYMERS IN DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF ORAL CONTROLLED DRUG DELIVERY SYSTEM OF FEXOFENADINE

Muthadi Radhika Reddy*, Sajal Kumar Jha, Kondapuram Parameshwar
Dept. of Pharmaceutics, School of Pharmacy Guru Nanak Institutions Technical Campus, Ibrahimpatnam, Hyderabad-501506, India.

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A STUDY TO ASSESS DRUG UTILIZATION ON TYPE 2 D/M PATIENTS WITH OR WITHOUT COMPLICATIONS IN GENERAL WARD OF TERTIARY CARE TEACHING HOSPITAL AT VIJAYANAGAR INSTITUTE OF MEDICAL SCIENCES, BALLARI, KARNATAKA

Mr. Arun J^1*, Sharad Chand², B. Nagaraju² , Mukul Acharya² , R. Anusha².
¹Assistant Professor, Department of Pharmacy Practice, TVM College of Pharmacy, Ballari, Karnataka.
²Department of Pharmacy Practice, TVM College of Pharmacy, Ballari, Karnataka.

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SKELETAL MUSCLE RELAXANT ACTIVITY OF BOUGAINVILLEA GLABRA LEAVES IN SWISS ALBINO MICE

Sudheer K Dokuparthi^1*, Suresh Kandagatla², Yesubabu Maddala², Shiva Shankar P²
¹Department of Pharmacognosy, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, India.
²Doer Innovations, LB Nagar, Telangana, India.

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SYNTHESIS OF 1-SUBSTITUTED-2-THIO-4-AMINO-6-ETHYLFORMAMIDINO,1,3,5-TRIAZINES

D. T. Tayade* S. P. Ingole
Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444606.

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ESTIMATION OF PHYTOCONSTITUENTS AND COMPARATIVE EVALUATION OF ANTI-OBESITY ACTIVITY OF AYURVEDIC AND HOMEOPATHIC MEDICINES IN HIGH FAT DIET ANIMAL MODEL

Saravanan Jayaram, Sangeetha Govindaraj, Ariharasivakumar Ganesan, Ramasamy Muthu, Jeevanantham Appusamy, Rajasekaran Aiyalu, Arivukkarasu Ramasamy
KMCH College of Pharmacy, Coimbatore, Tamilnadu, INDIA-641048.

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EVALUATION OF ANTI-CANCER ACTIVITY IN METHANOLIC EXTRACT OF ENICOSTEMMA LITTORALE ON DEN INDUCED HEPATOCARCINOGENESIS IN RATS

Abarnadevika Alagiri, Thanga kokila Mookiah, Ariharasivakumar Ganesan, Manisenthil Kumar Thigarajan, Rajasekaran Aiyalu, Arivukkarasu Ramasamy*
KMCH College of Pharmacy, Coimbatore, Tamilnadu, India-641048.

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IN VITRO EVALUATION OF ANTHELMINTIC ACTIVITY OF JUICE OF EUPHORBIA LIGULARIA ROXB.

Akshay M Baheti^*1, Shikha A. Baheti², Suvarna Ingale³, Chinmay Deshmukh¹, Manish S.Wani¹
¹MAEER’s Maharashtra Institute of Pharmacy, Paud Road, Pune, India- 411038.
²Sohit Pharmacy, Bavdhan, Pune.
³SCES, Indira College of Pharmacy, Wakad.

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PROTEOMIC STUDIES OF CHEMICAL CONSTITUENTS OF EUPHORBIA HIRTA

Nagavalli Dhandapani*, Saranya sundaralingam, Anu Baskaran, Aruna Muthusamy, Brindha Vasudevan, Dhivya Murugan, Divya Gopalakrishnan, Sujaritha jayaraj.
Adhiparasakthi College of Pharmacy, Melmaruvathur.

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DETERMENATION OF SIMULTANEOUS ESTIMATION HPLC METHOD FOR ELITRAGRAVIR, TENOFOVIR DISPROXIL FUMARATE, EMTRICITABINE AND COBICISTAT ITS BULK AND TABLET DOSAGE FORM.

S. K. Godasu, S. A. Sreenivas
Mewar University, Chittorgarh, Rajasthan.

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CLUSTER HEADACHES- A REVIEW

Nakka Varshitha*, D.Sai Aravind, Dr.G.Susmitha, Dr.G.Ramesh, Dr.V.Tejaswi, Dr.P.Srinivasa Babu
Department of Pharmacy Practice, Vignan Pharmacy College, vadlamudi, GunturS-A.P.

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SIDDHA THERAPEUTICS FOR THE MANAGEMENT OF PCOS - A REVIEW

A. Faridha*, Gayathri Gunalan, A. Rajendra Kumar
Siddha Regional Research Institute (CCRS), Kuyavarpalayam, Puducherry – 605013.

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AN OVERVIEW OF THE SIDDHA POLYHERBAL FORMULATION - ATHIMADHURA CHOORANAM FOR MIGRAINE HEADACHE

Mathipriya T¹, Kasirajan N², Maanickha Chelvi KS²
¹Siddha physician, Sankarankovil, Tamilnadu.
²Siddha Regional Research Institute, Thiruvananthapuram.

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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRROLYL PYRAZOLINE METHANONE DERIVATIVES

C. S. Hallikeri*, Poul Rubeza, Sheshagiri R. Dixit, Venkatarao H. Kulkarni, Shrinivas D. Joshi
Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical chemistry, S.E.T’s College of Pharmacy, Sangolli Rayanna Nagar, Dharwad 580 002, India.

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EVOLUTION OF CRUDE EXTRACT AND FRACTIONS OF Camellia sinensis LEAVES AGAINST HUMAN PATHOGENIC BACTERIALSTRAINS

Ganesan S*, Rajakumar R
Department of Biotechnology, MarudhuPandiyar College, Thanjavur-613 403, Tamil Nadu, India.

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A COMPREHENSIVE PHYTOPHARMACOLOGICAL REVIEW OF STEVIA REBAUDIANA

Pankaj Khuspe^1*, Kishori Kokate¹, Trushali Mandhare¹, Ajay Kharche², Prashant Kumar Katiyar²
¹Navsahyadri Institute of Pharmacy, Naigoan, Nasrapur, Pune-412213.
²Ideal College of Pharmacy & Research, Bhal, Kalyan-421306.

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A STUDY ON PRESCRIBING PATTERN OF ANTIMICROBIAL AGENTS IN PATIENTS SUFFERING FROM PELVIC INFLAMMATORY DISEASE IN A TERTIARY CARE TEACHING HOSPITAL

Anju Paulose*, Bharathi D.R.¹, B. Shankar Reddy¹, Anju Arpana², Anto John¹, Anu Rajan¹, Rahul Jose¹, Y Satyakrishna¹
¹Department of Pharmacy Practice, SJMCP, Chitradurga, Karnataka, India.
²Department of OBG, BMCH & RC, Chitradurga, Karnataka, India.

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DEVELOPMENT AND APPLICATION OF LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF OMBITASVIR, PARITAPREVIR AND RITONAVIR IN FIXED TABLET DOSAGE FORM

Mrs. Parbati Kirtania1, Dr. Nemala Appala Raju
Sultan-ul-Uloom College of Pharmacy, Road No.3, Banjara Hills, Hyderabad 500034.

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CASE REPORT ON THROMBOLYTIC THERAPY ASSOCIATED PONTINE HAEMORRHAGE AND ITS RISK FACTORS.

Dr. Soniya Davis^1*, Dr. Anju Paul¹, Dr Chinnu Reeba George¹, Dr. Priya Thomas¹, Dr. Arun Kumar², Dr. Jessy Thomas³
¹Department of Clinical Pharmacy, Lisie Hospital.
²Department of Neurology, Lisie Hospital.
³Department of Paediatric, Lisie Hospital

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