Welcome to Indo American Journal of Pharmaceutical Research

MAY 2017

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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FORMULATION AND EVALUATION OF A NEW LIPOSOMAL DRUG-IN-ADHESIVE PATCH FOR TRANSDERMAL DELIVERY OF SUMATRIPTAN SUCCINATE

M. Srujan Kumar^1*, Anna Balaji²

¹Institute of Pharmaceutical and Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004.

²Pathfinder Institute of Pharmacy Education and Research, Warangal, Telangana, India-506005.

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The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

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The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

REVIEW ON ZIZYPHUS JUJUBA RED DATE PLANT DRUG

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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A REVIEW ON NOVEL MOLECULAR MARKER TECHNIQUES AND THEIR APPLICATIONS IN PLANT ORIGIN

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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A REVIEW ON GLYCYRRHIZA GLABRA LINN. - A TRADITIONAL VERSATILE PLANT DRUG

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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A REVIEW ON PRUNELLA VULGARIS SELF HEAL PLANT DRUG

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CILNIDIPINE AND TELMISARTAN IN BULK AND DOSAGE FORM

Lalit Thakare*, Sufiyan Ahmad, V. M. Shastry

Department of Quality Assurance, Gangamai College of Pharmacy, Nagaon, Dist. Dhule (M.S.), India.

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A STUDY ON PREVALENCE AND DRUG UTILIZATION PATTERN IN DEPARTMENT OF ONCOLOGY OF TERTIARY CARE HOSPITAL IN INDIA

A. Spandana¹, K.L.K. Sneha¹, Dr. Balaiah Sandyapakula¹, Dr. Vinay Kumar.T¹, Dr.Charan Tej. K², Dr.S.A.Rahaman¹

¹Nirmala College of pharmacy, Mangalagiri, Guntur.

²Medical Superintendent, Manipal Hospitals, Vijayawada.

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APPLICATION OF QUALITY BY DESIGN FOR DEVELOPMENT OF ANALYTICAL RP-HPLC METHOD FOR RANITIDINE HCL

Derle Deelip V., Patil Mahendra S*, Patil Yogesh, Derle Nikita D.

Department of Quality Assurance, MVP’s College of Pharmacy, Nasik- 422002.

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CRITICALITY OF SOLUBILIZER SELECTION DURING FORMULATION DEVELOPMENT OF POORLY WATER SOLUBLE CEFIXIME

Poonam Mogal, Deeliprao Derle

Department of pharmaceutics, M.V.P.S’ College of pharmacy, Nashik, India.

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FORMULATION DEVELOPMENT OF ROPINIROLE HYDROCHLORIDE MICROEMULSION FOR INTRANASAL DELIVERY

Shubhrajit Mantry^1*, Anna Balaji²

¹Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer, Rajasthan- 305004, India.

²Pathfinder Institute of Pharmacy Education & Research, Beside Mamnoor Camp, Khammam Road, Warangal, India.

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IDENTIFICATION, EVALUATION AND ANALYSIS OF DRPs IN PATIENTS WITH SEIZURE DISORDERS IN A TERTIARY CARE TEACHING HOSPITAL

Alan Raju George, Aleena Joseph, Bithin Francis, Rilly Anil Mathew, Muneerudeen J*

Department of Pharmacy Practice, Bapuji Pharmacy College, Davanagere, Karnataka, India.

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BIOLOGICAL FINGER PRINTING OF MICROBIAL DIVERSITY IN VERMICOMPOST OF DIFFERENT RAW MATERIALS

Aruna A.P¹, Purushothaman Balakrishnan^1,2, Kumaran Shanmugam¹, K. Rajendran^1*

¹Department of Biotechnology, Periyar Maniammai University, Vallam Thanjavur, Tamilnadu.

²TanBio R & D Solution, Periyar TBI, Periyar Maniammai University, Vallam Thanjavur, Tamilnadu.

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Every day there are millions of the organic wastes were produced around the world and the processing of organic waste in to useful product is the difficult process. There are number of techniques were used to convert the organic waste into the useful products like bio fuel, manure etc., among them the mesophilic process using earthworms named Vermi-composting is one of the most eminent technology to process large amount of organic waste at low cost. The most significant of the process is not only to improve the fertility of the soil but also improve the diversity of useful microorganism by eradicating the harmful one.The current study is to investigate the presence of the microbial diversity in vermicast feeded with different source (cow dung, slurry, and press-mud) and find the best one by compare among them. The vermicomposting unit used in this study was placed at the Periyar Maniammai University, Vallam, Thanjavur, Tamilnadu, india. The process was done by open bed method and six separate beds were constructed in the following sequence 1- slurry, 2- slurry with earthworms, 3-cow dung, 4-cow dung with earthworms, 5-pressmud, and 6-pressmud with earthworms. On the 42nd day the process was terminated for samples 2,4 & 6 and the samples were collected from each bed and proceeded to the meta-genomic analysis to observe the presence of different combination of microorganisms in different composting bed. The meta-genomics sequence results were categorized from higher order phylum to lower species level and it indicates that large quantity and diversity of microbes like Bacteroidetes, Proteobacteria etc., were present in all the vermicast when compare with the non compost samples. Finally, we concluded that our results indicate vermicast obtained from the night soil slurry did not have any pathogenic bacteria like Salmonella spp., Escherichia coli, Enterobacter spp., and Enterococcus spp. In addition to that, it had most harmless diversified bacteria useful for the plant growth and mostprominent one when compare with others in our study. In summary, analysis using meta-genomic sequencing is the most predominant technology for the characterization of microbial composition in vermicast and it should be the most supporting tool to determine necessary measures to handle manure safely.

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Every day there are millions of the organic wastes were produced around the world and the processing of organic waste in to useful product is the difficult process. There are number of techniques were used to convert the organic waste into the useful products like bio fuel, manure etc., among them the mesophilic process using earthworms named Vermi-composting is one of the most eminent technology to process large amount of organic waste at low cost. The most significant of the process is not only to improve the fertility of the soil but also improve the diversity of useful microorganism by eradicating the harmful one.The current study is to investigate the presence of the microbial diversity in vermicast feeded with different source (cow dung, slurry, and press-mud) and find the best one by compare among them. The vermicomposting unit used in this study was placed at the Periyar Maniammai University, Vallam, Thanjavur, Tamilnadu, india. The process was done by open bed method and six separate beds were constructed in the following sequence 1- slurry, 2- slurry with earthworms, 3-cow dung, 4-cow dung with earthworms, 5-pressmud, and 6-pressmud with earthworms. On the 42nd day the process was terminated for samples 2,4 & 6 and the samples were collected from each bed and proceeded to the meta-genomic analysis to observe the presence of different combination of microorganisms in different composting bed. The meta-genomics sequence results were categorized from higher order phylum to lower species level and it indicates that large quantity and diversity of microbes like Bacteroidetes, Proteobacteria etc., were present in all the vermicast when compare with the non compost samples. Finally, we concluded that our results indicate vermicast obtained from the night soil slurry did not have any pathogenic bacteria like Salmonella spp., Escherichia coli, Enterobacter spp., and Enterococcus spp. In addition to that, it had most harmless diversified bacteria useful for the plant growth and mostprominent one when compare with others in our study. In summary, analysis using meta-genomic sequencing is the most predominant technology for the characterization of microbial composition in vermicast and it should be the most supporting tool to determine necessary measures to handle manure safely.

PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW OF SURANJAN SHIREEN (Colchicum autumnale)

Shahid Suhail*, S. Shakir Jamil, Shazia Jilani, Shabnam Ansari, Amjad W.Yousuf

Department of Moalajat, School of Unani Medicine, Jamia Hamdard, New Delhi, India.

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PREPARATION AND IN VITRO EVALUATION OF SOLID DISPERSION OF FINASTERIDE

Jamal Ali Ashoor, Qasim Allawi Bader, Mohammed Fanokh Abo Khthr, Hasanain Shakir Mahmood

College of Pharmacy, Karbala University, Iraq.

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ASSESSMENT OF PRESCRIBING PATTERN OF ANTIBIOTICS AND WHO PRESCRIBING INDICATORS IN PAEDIATRICS DEPARTMENT

B.VinolyJeevan*, D. SaiSravani, AN. Anusha Reddy, Y. Vamseedhar, D. Giri Raja Sekhar, Chakka Gopinath

Assistant Professor, Department of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet-516115.

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EVALUATION OF ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF CLEOME VISCOSA L.

Chandrasekaran Swaminathan

Assistant Professor, Department of Microbiology, Vivekanandha College of Arts and Science for Women (Autonomous), Tiruchengode, India.

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FORMULATION OPTIMIZATION AND IN-VITRO EVALUATION OF NANOSTRUCTURED LIPID CARRIER CONTAINING ANTIPSYCHOTIC DRUG

Arpita Nath*, Vilasrao Kadam

Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, sector-8, C.B.D., Belapur, Navi Mumbai-400 614, Maharashtra, India.

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INFLUENCE OF TRICHODERMA HARZIANUM T22 TO ENRICH THE MINERALS REQUIRES FOR PLANT GROWTH IN VERMICAST

M. Agnes Sharmila, M. Jegadeesan*

Department of Environmental and Herbal Science, Tamil University, Thanjavur, Tamilnadu.

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MILK ADULTERATION A REVIEW

Justin K Joy¹, K. Krishnakumar²

¹Dept. of Pharmaceutical Chemistry, St James College of Pharmaceutical Sciences, Chalakudy.

²St James Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy, Kerala.

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ANALYTICAL, BIOLOGICAL AND PHYLOGENETIC STUDIES OF CLERODENDRUM PHLOMIDIS LINN. F. LEAVES

MK MohanMarugaRaja¹, Agilandeswari Devarajan^2*

¹Pharmacy Department, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India.

²Department of Pharmaceutics, Hillside College of Pharmacy and Research Centre, Bengaluru, Karnataka, India.

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A NOVEL UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION FOR DETECTION AND QUANTIFICATION OF VANCOMYCIN IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM

M.Susima*, Shaik Muneer, K.B. Chandra Sekhar, J. Komala Preethi, T. Latha, G. Koundilya, G.Ramesh

Department of Pharmaceutical Sciences, JNTUA- Oil Technological and Pharmaceutical Research Institute, Ananthapuramu- 515001, A.P, India.

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ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTI-PARKINSONS SCREENING OF AZOMETHINE ANALOGUES THROUGH HSP90 INHIBITION

Dr. M. Ganga Raju*, Divya N

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad.

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A REVIEW ON APPLICATIONS OF MOLECULAR DOCKING IN DRUG DESIGNING

M. Venkata Saileela¹*, Dr. M. Venkateswar Rao², Venkata Rao Vutla¹

¹Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur.

²Department of Pharmacology, Guntur Medical College, Guntur.

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STUDY OF GROWTH PROMOTION AND HEALTH BENEFITS OF AYU-809 GENERAL NUTRITIONAL SUPPLEMENT IN RATS

Priyanka Shrestha¹, Biplav Syngkli¹, Sri Vidya², Shanaz Tejani-butt³, Shivalinge Gowda KP.*

¹Department of Pharmacology, PES College of Pharmacy, Bengaluru, Karnataka, India.

²Ayurwin Pharma Pvt. Ltd, Bengaluru, Karnataka.

³University of the Sciences in Philadelphia, Philadelphia, PA, USA.

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SOLUBILITY AND DISSOLUTION ENHANCEMENT OF A BCS CLASS II DRUG BY CO-GRINDING WITH SUPERDISINTEGRANTS

Suraj N. Pattekari^1*, Dr. Ajit S. Kulkarni²

¹Indira Institute of Pharmacy, Sadavali. Tal: Sangameshwar, Dist: Ratnagiri, M.S., India, 415804.

²Satara College of Pharmacy, Satara. Plot No. 1539, Behind Spicer India Ltd., New additional M.I.D.C., At. Degaon, Satara, M.S., India, 415004.

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INGREDIENTS IDENTIFICATION, PHYSICO-CHEMICAL AND HPTLC EVALUATION OF VAJIGANDHADI TAILA A POLYHERBAL FORMULATION

Surendra Kumar*, K.S. Patel, A.B.Thakar, C.R. Harisha, Shukla V.J.

Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.

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