Welcome to Indo American Journal of Pharmaceutical Research

JANUARY 2017

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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FORMULATION AND EVALUATION OF A NEW LIPOSOMAL DRUG-IN-ADHESIVE PATCH FOR TRANSDERMAL DELIVERY OF SUMATRIPTAN SUCCINATE

M. Srujan Kumar^1*, Anna Balaji²

¹Institute of Pharmaceutical and Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004.

²Pathfinder Institute of Pharmacy Education and Research, Warangal, Telangana, India-506005.

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The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

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The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

REVIEW ON ZIZYPHUS JUJUBA RED DATE PLANT DRUG

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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A REVIEW ON NOVEL MOLECULAR MARKER TECHNIQUES AND THEIR APPLICATIONS IN PLANT ORIGIN

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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A REVIEW ON GLYCYRRHIZA GLABRA LINN. - A TRADITIONAL VERSATILE PLANT DRUG

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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A REVIEW ON PRUNELLA VULGARIS SELF HEAL PLANT DRUG

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

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FORMULATION DEVELOPMENT OF ROPINIROLE HYDROCHLORIDE MICROEMULSION FOR INTRANASAL DELIVERY

Shubhrajit Mantry^1*, Anna Balaji²

¹Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer, Rajasthan- 305004, India.

²Pathfinder Institute of Pharmacy Education & Research, Beside Mamnoor Camp, Khammam Road, Warangal, India.

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LIFESTYLE MODIFICATION: KNOWLEDGE, ATTITUDE AND PRACTICE AMONG DIABETIC PATIENTS HAVING CHRONIC FOLLOW UP IN HIWOT FANA SPECIALIZED UNIVERSITY HOSPITAL, EASTERN ETHIOPIA

Ousman Ahmed¹, Jemal Abdela², Mekonnen Sisay^2*

¹College of Health Sciences, Woldiya University, Wollo, Ethiopia.

²School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

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Diabetes mellitus is a chronic metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with the risk of developing micro-and macro-vascular complications. This study was aimed at assessing the knowledge, attitude and practice on life style modification of diabetic patients having chronic follow up at the diabetic clinic. Hospital based cross-sectional study was conducted in Hiwot Fana Specialized University Hospital (HFSUH) from March 1-30, 2015 G.C. Convenience sampling technique was applied to select eligible diabetic patient. Data, regarding the knowledge, attitude and practice on lifestyle modification (LSM) of eligible diabetic patients on chronic follow up at HFSUH, was collected prospectively using interview with the help of a structured questionnaire. Data was entered into SPSS version 16 for analysis. Some statistical associations using Pearson chi-square test were made as necessary and P value < 0.05 was considered statistically significant. Concerning the knowledge of the diabetic patients towards LSM; majority of them were found to be knowledgeable and accounts 64.2% followed by 27.2% patients who were averagely knowledgeable. Regarding the attitude of patients towards non pharmacological therapeutic approaches, majority of those (96%) had very good attitude followed by good attitude (1.2%) and poor attitude (2.9%) towards LSM. The large proportion of respondents have been with very good practice (74.6%) followed by those with average practice (20.5%). There is a significant association between knowledge and educational status (p=0.000), occupation (p=0.000) as well as area of residence (p=0.000). In addition, a significant association was observed between attitude and occupation (p=0.010) as well as residence (p=0.006). Similarly, statistically significant association was also shown between practice and occupation (p=0.040) and area of residence (p = 0.007). Generally, the majority of respondents has very good knowledge, while in the case of attitude and practice, majority of them have a good attitude and practice. Since LSM plays a pivotal role in the management of chronic diseases like DM, the health care professionals should give great emphasis for it for betterment of the overall therapeutic outcome.

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Diabetes mellitus is a chronic metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with the risk of developing micro-and macro-vascular complications. This study was aimed at assessing the knowledge, attitude and practice on life style modification of diabetic patients having chronic follow up at the diabetic clinic. Hospital based cross-sectional study was conducted in Hiwot Fana Specialized University Hospital (HFSUH) from March 1-30, 2015 G.C. Convenience sampling technique was applied to select eligible diabetic patient. Data, regarding the knowledge, attitude and practice on lifestyle modification (LSM) of eligible diabetic patients on chronic follow up at HFSUH, was collected prospectively using interview with the help of a structured questionnaire. Data was entered into SPSS version 16 for analysis. Some statistical associations using Pearson chi-square test were made as necessary and P value < 0.05 was considered statistically significant. Concerning the knowledge of the diabetic patients towards LSM; majority of them were found to be knowledgeable and accounts 64.2% followed by 27.2% patients who were averagely knowledgeable. Regarding the attitude of patients towards non pharmacological therapeutic approaches, majority of those (96%) had very good attitude followed by good attitude (1.2%) and poor attitude (2.9%) towards LSM. The large proportion of respondents have been with very good practice (74.6%) followed by those with average practice (20.5%). There is a significant association between knowledge and educational status (p=0.000), occupation (p=0.000) as well as area of residence (p=0.000). In addition, a significant association was observed between attitude and occupation (p=0.010) as well as residence (p=0.006). Similarly, statistically significant association was also shown between practice and occupation (p=0.040) and area of residence (p = 0.007). Generally, the majority of respondents has very good knowledge, while in the case of attitude and practice, majority of them have a good attitude and practice. Since LSM plays a pivotal role in the management of chronic diseases like DM, the health care professionals should give great emphasis for it for betterment of the overall therapeutic outcome.

ASSESSMENT OF MODERN FAMILY PLANNING USE AND ASSOCIATED FACTORS AMONG MARRIED WOMEN IN REPRODUCTIVE AGE, IN ILU ABABORA ZONE OROMIYA REGION, SOUTH WEST ETHIOPIA, 2014.

Alebachew Birhan, Bikela Tesfa.

Department of Midwifery, Faculty of Public Health and Medical Science, Mettu University. Ethiopia.

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Background: Family planning services are an essential part of reproductive health care and it is among the top internationally agreed interventions of safe motherhood that enable developing countries achieving millennium development goals through increasing its use thereby decreasing maternal and child mortality and morbidity. Family planning service enables couples to decide the number and spacing of their children which is crucial to safe motherhood and healthy families. While the use of modern contraceptive methods has increased globally to 55%, many of the developing countries are still experienced with low utilization of modern contraceptives. Sub-Saharan African countries have the lowest contraceptive use in which only 17% of women in reproductive age group use modern contraceptives methods. Studies were also conducted elsewhere in different countries to identify factors influencing the utilization of family planning services and have identified socio cultural, socio economic, reproductive and facility related factors affecting the utilization. Despite these efforts made, still the utilization of modern family planning is very low in developing world and sub-Saharan countries particularly in Ethiopia. So that conducting this study in Alle, Darimu, Hurumu, Didessa districts and Bedelle town, Ilu Aba Bora Zone is mandatory to get factors affecting modern contraceptive use since no study was conducted on similar topic. Methods:- A community based cross-sectional study design was conducted in Ilu Aba Bora Zone, Oromiya region, south-West Ethiopia from February to March 2014. Reproductive age women (15-49 years), currently married were participated in the study. Structured interviewer administered questionnaire were used to collect the data which is developed after reviewing different relevant literatures and similar studies. Data were entered, cleaned (explored) for outliers, missed values and missed variables were analyzed using SPSS version 20. Different frequency tables, graphs and descriptive summaries were used to describe the study variables. Bivariate analyses were performed to see the existence of association between dependent and independent variables. Results: - Six hundred fifteen married women were included in the study with a response rate of 92.2%. Majority of the women 467(79%) are using modern family planning. From this more than half of the women 392 (84.3%) are Depo-Provera users whereas 50(10.8%), 18(3.9%) and 4(1%) are Norplant, pills and IUCD users respectively. Multiple logistic regression analysis shows that modern family planning was significantly associated with residence of the respondents in which those who live in urban has 29% more likely to have history of using (AOR/95%CI =0.29/ .150-.54/0.001) than who live in rural area. Conclusion and recommendations:- in the zone modern contraceptive methods use among currently married women of reproductive age group is high. However, women’s demand for more children has a negative effect on the use of modern contraceptive methods.so community awareness about modern contraceptive family planning methods and family size is important.

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Background: Family planning services are an essential part of reproductive health care and it is among the top internationally agreed interventions of safe motherhood that enable developing countries achieving millennium development goals through increasing its use thereby decreasing maternal and child mortality and morbidity. Family planning service enables couples to decide the number and spacing of their children which is crucial to safe motherhood and healthy families. While the use of modern contraceptive methods has increased globally to 55%, many of the developing countries are still experienced with low utilization of modern contraceptives. Sub-Saharan African countries have the lowest contraceptive use in which only 17% of women in reproductive age group use modern contraceptives methods. Studies were also conducted elsewhere in different countries to identify factors influencing the utilization of family planning services and have identified socio cultural, socio economic, reproductive and facility related factors affecting the utilization. Despite these efforts made, still the utilization of modern family planning is very low in developing world and sub-Saharan countries particularly in Ethiopia. So that conducting this study in Alle, Darimu, Hurumu, Didessa districts and Bedelle town, Ilu Aba Bora Zone is mandatory to get factors affecting modern contraceptive use since no study was conducted on similar topic. Methods:- A community based cross-sectional study design was conducted in Ilu Aba Bora Zone, Oromiya region, south-West Ethiopia from February to March 2014. Reproductive age women (15-49 years), currently married were participated in the study. Structured interviewer administered questionnaire were used to collect the data which is developed after reviewing different relevant literatures and similar studies. Data were entered, cleaned (explored) for outliers, missed values and missed variables were analyzed using SPSS version 20. Different frequency tables, graphs and descriptive summaries were used to describe the study variables. Bivariate analyses were performed to see the existence of association between dependent and independent variables. Results: - Six hundred fifteen married women were included in the study with a response rate of 92.2%. Majority of the women 467(79%) are using modern family planning. From this more than half of the women 392 (84.3%) are Depo-Provera users whereas 50(10.8%), 18(3.9%) and 4(1%) are Norplant, pills and IUCD users respectively. Multiple logistic regression analysis shows that modern family planning was significantly associated with residence of the respondents in which those who live in urban has 29% more likely to have history of using (AOR/95%CI =0.29/ .150-.54/0.001) than who live in rural area. Conclusion and recommendations:- in the zone modern contraceptive methods use among currently married women of reproductive age group is high. However, women’s demand for more children has a negative effect on the use of modern contraceptive methods.so community awareness about modern contraceptive family planning methods and family size is important.

BUDD-CHIARI SYNDROME; A CASE REPORT IN GENERAL MEDICINE DEPARTMENT

Dr. S. Chandrababu¹, Dr. S. Kavitha¹, C. V. Jagadishwar*¹, A. Lokesh², P. Venkataramana³, M. Sam jeeva kumar³, G. Mahesh²

¹General Medicine Department, Rajiv Gandhi Institute of Medical Sciences(RIMS), Kadapa, India- 516003.

²Rajiv Gandhi Institute of Medical Sciences (RIMS), PRRMCP, Kadapa, India-516003.

³P. Rami Reddy Memorial College of Pharmacy, Kadapa, India-516003.

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DEPRESSION AND ASSOCIATED FACTORS AMONG ADULT PEOPLE LIVING WITH HIV/AIDS ATTENDING METU KARLI HOSPITAL ILUABABOR ZONE , SOUTH WEST ETHIOPIA

Geremew Tolessa Dugul, Fikadu Balcha, Melese Workneh

Department of Nursing, Mettu University, Medical and Health Sciences Faculty.

Department of Nursing, Jimma University, College of Public Health and Medical Sciences, Jimma, Ethiopia.

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HIV is major public problem in the world and in Sub-Saharan Region in particular. The literature has shown that mental disorders and particularly depression are common among people living with HIV/AIDS, but that little is known about the prevalence, level of depression and factors associated with it, among people living with HIV/AIDS. The main objective of this study is to assess depression and associated factors among HIV/AIDs patients attending Metu Karl hospital, Ilu Ababora Zone, South west Ethiopia. Institution based cross-sectional study was performed to examine depression and associated factors among PLWHA attending Metu Karl Hospital. 387 PLWHA were selected using Simple random sampling technique with response rate of 98%. Data were collected using structured and pre-tested questionnaire. Five data collectors and one supervisor were trained and involved in data collection process. Data were coded, numbered, entered and analyzed using SPSS version 16.0. Binary and multivariate Logistic regression was performed to determine each factor and how they are associated with depression. The level and prevalence of depression was determined in this study. According to this finding the overall depression was 48% of these, 15%, 24% and 9%were mild, moderate, and severe depression respectively the rest were normal for depression as well as some associated factors were internalized stigma, having CD4 less than 250, being female and less social support. For all the socio-demographic factors, psychosocial factors and HIV medical related factors that were studied, it emerged that being a female and lack of social support, internally stigmatized being single, divorced and widowed were statistically associated with depression. Also the numbers of CD4 counts bellow 250 were statistically associated with depression. Nursing practice and Nursing and public health research and PLWHA are recommended on giving health education for clients, doing research on this area.

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HIV is major public problem in the world and in Sub-Saharan Region in particular. The literature has shown that mental disorders and particularly depression are common among people living with HIV/AIDS, but that little is known about the prevalence, level of depression and factors associated with it, among people living with HIV/AIDS. The main objective of this study is to assess depression and associated factors among HIV/AIDs patients attending Metu Karl hospital, Ilu Ababora Zone, South west Ethiopia. Institution based cross-sectional study was performed to examine depression and associated factors among PLWHA attending Metu Karl Hospital. 387 PLWHA were selected using Simple random sampling technique with response rate of 98%. Data were collected using structured and pre-tested questionnaire. Five data collectors and one supervisor were trained and involved in data collection process. Data were coded, numbered, entered and analyzed using SPSS version 16.0. Binary and multivariate Logistic regression was performed to determine each factor and how they are associated with depression. The level and prevalence of depression was determined in this study. According to this finding the overall depression was 48% of these, 15%, 24% and 9%were mild, moderate, and severe depression respectively the rest were normal for depression as well as some associated factors were internalized stigma, having CD4 less than 250, being female and less social support. For all the socio-demographic factors, psychosocial factors and HIV medical related factors that were studied, it emerged that being a female and lack of social support, internally stigmatized being single, divorced and widowed were statistically associated with depression. Also the numbers of CD4 counts bellow 250 were statistically associated with depression. Nursing practice and Nursing and public health research and PLWHA are recommended on giving health education for clients, doing research on this area.

ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF CHONEMORPHA FRAGRANS AND ERYTHROXYLUM MONOGYNUM COMBINED ETHANOLIC LEAF EXTRACT IN ALLOXAN INDUCED DIABETIC WISTAR RATS

KAUSAR FATIMA*, KONDE ABBULU

Department of Pharmacology, CMR College of Pharmacy, Medchal, Hyderabad, Telangana.

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A REVIEW ON ANTI-MICROBIAL PROPERTIES OF MURRAYA KOENIGII

Shanmuga Sundari Ilangovan, Pranit Krishna, Koushika Das, Shampa Sen*
School of Biosciences and Technology, VIT University, Vellore, India.

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EVALUATION OF SYNERGISTIC EFFECT OF GREEN TEA AND HORSE GRAM POWDER EXTRACT ON THE TREATMENT OF DIABETES INDUCED RATS

Dhanalaxmi Mohan Raj^1*, Dr.K. Bhaskar Reddy²

¹Pacific Academy of Higher Education and Research University, Udaipur, Rajsthan, India.

²Sri Venkateswara College of Pharmacy, R.V.S Nagar, Tirupati Road, Chitoor-517127, Andhra Pradesh, India.

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IN VITRO ANTICANCER ACTIVITY OF ETHANOLIC LEAF EXTRACT OF HYBANTHUS ENNEASPERMUS L., AGAINST HEp-2 CELL LINE

Jaikumar K, Sheik Noor Mohamed M, Marimuthu S, Anantha Padmanabhan S, Anand D, Saravanan P*

P.G & Research Department of Botany, Ramakrishna Mission Vivekananda College, Mylapore, Chennai-600 004, Tamil nadu, India.

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TITRIMETRIC ASSAY OF RANITIDINE HYDROCHLORIDE USING MERCURY(II) NITRATE REAGENT AND MERCURY(II) THIOCYANATE-IRON(III) NITRATE INDICATOR SYSTEM

Shivaji Rangnath Labhade^1*, Kailas Rangnath Labhade², Pravin Dinkar Harak³, Vishwas Bhaskar Gaikwad⁴

¹K.R.T.Arts, B.H. Commerce and A.M. Science (K.T.H.M.) College, Nashik- 422 002, Maharashtra, India.

²S.V.K.T. Arts, Science and Commerce College, Deolali Camp, Nashik- 422 401, Maharashtra, India.

³Food and Drug Inspector, Government of Maharashtra, Aurangabad Division, Maharashtra, India.

⁴Director, BCUD, Savitribai Phule Pune University, Ganeshkhind, Pune-411 007, Maharashtra, India.

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DEVELOPMENT OF ODT OF ATORVASTATIN CALCIUM β CYCLODEXTRIN COMPLEX

Y. Sowmya, G. Uma Rani

RBVRR Womens College of Pharmacy, Barkatpura, Hyderabad, Telangana.

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METHOD DEVELOPMENT AND VALIDATION OF IXAZOMIB CITRATE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY RP- HPLC

S. V. Saibaba^*1, Dr. P. Shanmuga Pandiyan²

¹Research Scholar, Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan.

²Reseacrh Supervisor, Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan.

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ASSESSMENT OF ANTIHYPERLIPIDEMIC ACTIVITY FOR METHANOLIC EXTRACT OF NYCTANTHES ARBOR-TRISTIS (LINN.) LEAVES

Sneha J Anarthe*, M. Swetha, P. Spoorthisudha, M. Ganga Raju

Department of Pharmacology Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad- 500090, India.

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PHARMACEUTICAL APPLICATION AND IMPLEMENTATION OF MICROEMULSION AS A CARRIER SYSTEM FOR INSOLUBLE COMPOUNDS

Pallavi P. Pawar, Nilam Tawre, Rahul H. Kirange*

S. Zhaveri Pharmakem Pvt Ltd, Dombivli Midc. Dombivli (E), Maharashtra, India 421 203.

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A SURVEY ON REQUIERED FACILITY AND TREATMENT IN EMERGENCY IN HOSPITAL OF DEHRADUN CITY

Popin Kumar*, Indu Tiwari, Tulsi Bisht

Gyani Inder Singh Institute of Professional Studies, Opp. Malsi Deer Park, Post: Sinola, Dehradun, Uttarakhand, 248003.

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APPLICATION OF HOT MELT EXTRUSION TO ENHANCE THE DISSOLUTION OF BOSENTAN MONOHYDRATE

Ranga Harish, Dr. T. E. G. K. Murthy, Dr. K. B. Chandrasekhar.

Matrix Laboratories, Hyderabad.

Department of Pharmaceutics, Bapatla College of Pharmacy, Oil Technological and Pharmaceutical Research Institute, JNTUA, Ananthapuramu.

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EVALUATION OF ANTIOXIDANT POTENTIAL OF KINNOW FRUIT JUICE ON COGNITIVE IMPAIRED ALBINO RATS

Kumar Neeraj^*1, Sharma Sanjay²

¹Jodhpur National University, Jodhpur (Raj.).

²School of Pharmacy and Technology Management, SVKM’ S NMIMS, Shirpur (Maharashtra).

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A NOVEL VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF MIRABEGRON IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS

Srikanth Inturi^*, Prameela Rani A, Venkata Pavan Kumar G

Dept .of Pharmacy, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur-522 510, A.P, India.

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FORMULATION AND EVALUATION OF COMPRESSION COATED PIROXICAM TABLETS FOR COLON SPECIFIC DRUG DELIVERY

Chitta Venkateswararao^*1, J. Venkata Suresh², Mr. G. Nagarujanareddy³

KLR Pharmacy College, Palvoncha, Khammam-507115.

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MALIGNANCIES ASSOCIATED WITH IMMUNOSUPPRESSANT IN DERMATOLOGY

Arjan Aryal

Department of Pharmacy Practice, Krupanidhi College of Pharmacy, Bangalore- 560035, Karnataka, India.

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SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NOVEL QUINOLINE BASED PYRAZOLINES

Naqui Jahan Siddiqui*¹, Supriya Majumdar², Mohammad Idrees¹

¹Government Institute of Science, Nagpur-440001, Maharashtra, India.

²Government Science College, Gadchiroli-442605, Maharashtra, India.

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