Welcome to Indo American Journal of Pharmaceutical Research

AUGUST 2017

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

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Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

AN IMPACT OF EDUCATIONAL INTERVENTION OF ADVERSE DRUG REACTIONS REPORTING TO AMC-PvPI AMONG NURSES IN TERTIARY CARE TEACHING HOSPITAL

Venkata RamaRao Nallani^*1, Dr.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, Paher University, Udaipur.
⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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CLINICAL PHARMACIST IS KEY ROLE OF THE PATIENT-CENTERED CARE IN TERTIARY CARE TEACHING HOSPITALS IN INDIAN SENERIO

Venkata Ramarao Nallani^*1, Prof.Rama Rao Nadendla², Dr. Khemchand Gupta³, Dr. Zahedabano⁴
¹Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
²Chalapathi Institute of Pharmaceutical Sciences, Guntur.
³Associate Professor, PAHER University, Udaipur.

⁴Dept of Pharmacology, Guntur Medical College, Guntur.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

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Pharmacist traditionally involving compounding, production and dispensing of drugs from ancient times. As the diseases and sedentary life style leads to complications to use of more medications to manage the disease and life style problems, this is the time to identify the unsafe and irrationalize medicine medical therapy has emerged. This has also contributed to clinical pharmacists being more involved in patient-centered pharmacotherapy. A large literature documents the multiple roles clinical pharmacists can play in a variety of health care settings. The main aim of the study is role of clinical pharmacist in modifying disease outcome by patient centered care in the medical wards.Clinical pharmacist role between physician and patient to provide drug information, economic benefits, patient compliance, drug related problems (DRP), to determine the effect of patient counseling on quality of life of patient. METHODOLOGY- The prospective observational study to conducts for a period of two and half years about 30 months in patient departments in a tertiary care hospital in South India. promoting better medication use, ensuring that patients receive appropriate pharmacotherapy, thus minimizing the risk of unfavorable outcomes of pharmacotherapy adherence scale. RESULTS & DISCUSSION- A total of 1263 patients out of 6548 inpatients of general medicine department were followed out of which having one or more drug related problems. Female (56.7%) [Table-22] predominance was noted over males (43.3%). Drug related problems were more commonly seen in patients aged between 41-60 years, (47.92 %). A total of 240 drug related problems were identified. Most of the DRP observed in the study resulted from the inappropriate drug dosing problems (25.42%) followed by drug selection (24.16%)[Table-23]. Majority of the clinical pharmacist recommendations were on drug discontinuation (29.58%) and drug doses change (22.6%). CONCLUSION- The study concludes that involving clinical pharmacist services in patients care can significantly helps to identify, resolve and prevent the DRPs in the hospital thereby enhancing the patients outcomes. Furthermore, the suggestions provided by the clinical pharmacist during the intervention were well accepted by the physician thus the collaborative approach of physician and clinical pharmacist can provide better patients centre care outcomes. The study stresses the importance of clinical pharmacist in health care sector and impeccable role in patients care.

FORMULATION AND EVALUATION OF A NEW LIPOSOMAL DRUG-IN-ADHESIVE PATCH FOR TRANSDERMAL DELIVERY OF SUMATRIPTAN SUCCINATE

M. Srujan Kumar^1*, Anna Balaji²

¹Institute of Pharmaceutical and Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004.

²Pathfinder Institute of Pharmacy Education and Research, Warangal, Telangana, India-506005.

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The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

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The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

ASSESSMENT OF DRUGS IN POST-OPERATIVE PAIN MANAGEMENT

Vinoothna Bavireddy, Harini Keesara, Prahalicka Myakala, Yaka Lavanya

Doctor of Pharmacy, Sree Dattha Institute of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, Sheriguda, Ibrahimptanam- 501510.

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IN VITRO STUDIES ON PRELIMINARY PHYTOCHEMICAL SCREENING OF PLEUROTUS FLORIDA CULTIVATED ON PADDY STRAW

K. MANIMARAN, S. MURUGESAN*, S. LAKSMIKANTH

Research Scholar, Department of Botany, Periyar University, Salem-11, Tamil Nadu, India.

*Assistant Professor, Department of Botany, Periyar University, Salem-11, Tamil Nadu, India.

PG Department of Botany, Periyar University, Salem-11, Tamil Nadu, India.

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Mushrooms are white rot fungi regarded as one of the well known food and possessing various kinds of biopharmaceuticals compounds. Mushrooms are superior to many vegetables based on their nutritional value and it contains 40 - 49% of proteins. The present study consolidates in the aspects of cultivation of Pleurotus florida mushroom with phytochemical analysis. Pleurotus florida mushroom was cultivated by using paddy straw. Oyster mushroom accounted for 14.2% of the total world production of edible mushroom.P. florida was successfully grown on PDA. The fresh fruit bodies of mushroom were harvested, dried, powdered and extracted (by using ethanol) using soxhlate apparatus. The phytochemical characters of Pleurotus florida of water and ethanol extract investigated.The aqueous extract of Pleurotus florida was found to contain alkaloids, flavonoids, terpenoids, steroids and cardiac glycosides. Whereas ethanol extract of Pleurotus florida showed, the presence of alkaloids, flavonoids, terpenoids, saponins and steroids. Aqueous, ethanolic and methanolic extracts contains high amount of phenolic compounds, glycosides and flavonoids based on the phytochemical screening. CONCLUSION: In the present investigation was carried out on cultivation of Pleurotus florida and screening of preliminary phytochemicals. Pleurotus florida was cultivated on sterilized paddy straw. Environmental factors of pH (6.5) and temperature (25– 300C) were maintained between mycelia growth to attain harvesting stage. Cultivation of the growth was observed in raw materials in 18-25 days and first harvest can be made on 19th day itself it implies that the growth of the mushroom. Total yield was one kg for one bed. Preliminary phytochemical compounds were screened of Pleurotus florida with different extract of aqueous and ethanol solvent. Alkaloids, flavonoids, terpenoids, steroids and cardiac glycosides were presence in aqueous extract of Pleurotus florida. Whereas ethanol extract of Pleurotus florida was contain alkaloids, flavonoids, terpenoids, saponins and steroids. Some phytochemical ingredients Phenols, tannins, pholobatannins and anthroquinones were absence in both extracts. Further study can be aimed at to identify the bioactive compounds and determine the cultivation of Pleurotus florida on paddy Straw.

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Mushrooms are white rot fungi regarded as one of the well known food and possessing various kinds of biopharmaceuticals compounds. Mushrooms are superior to many vegetables based on their nutritional value and it contains 40 - 49% of proteins. The present study consolidates in the aspects of cultivation of Pleurotus florida mushroom with phytochemical analysis. Pleurotus florida mushroom was cultivated by using paddy straw. Oyster mushroom accounted for 14.2% of the total world production of edible mushroom.P. florida was successfully grown on PDA. The fresh fruit bodies of mushroom were harvested, dried, powdered and extracted (by using ethanol) using soxhlate apparatus. The phytochemical characters of Pleurotus florida of water and ethanol extract investigated.The aqueous extract of Pleurotus florida was found to contain alkaloids, flavonoids, terpenoids, steroids and cardiac glycosides. Whereas ethanol extract of Pleurotus florida showed, the presence of alkaloids, flavonoids, terpenoids, saponins and steroids. Aqueous, ethanolic and methanolic extracts contains high amount of phenolic compounds, glycosides and flavonoids based on the phytochemical screening. CONCLUSION: In the present investigation was carried out on cultivation of Pleurotus florida and screening of preliminary phytochemicals. Pleurotus florida was cultivated on sterilized paddy straw. Environmental factors of pH (6.5) and temperature (25– 300C) were maintained between mycelia growth to attain harvesting stage. Cultivation of the growth was observed in raw materials in 18-25 days and first harvest can be made on 19th day itself it implies that the growth of the mushroom. Total yield was one kg for one bed. Preliminary phytochemical compounds were screened of Pleurotus florida with different extract of aqueous and ethanol solvent. Alkaloids, flavonoids, terpenoids, steroids and cardiac glycosides were presence in aqueous extract of Pleurotus florida. Whereas ethanol extract of Pleurotus florida was contain alkaloids, flavonoids, terpenoids, saponins and steroids. Some phytochemical ingredients Phenols, tannins, pholobatannins and anthroquinones were absence in both extracts. Further study can be aimed at to identify the bioactive compounds and determine the cultivation of Pleurotus florida on paddy Straw.

EXCIPIENT FUNCTIONALITY OF A NOVEL HYDROPHILIC BIOPOLYMER DERIVED FROM IPOMOEA BATATAS TUBERS

Kenneth Chinedu Ugoeze, Nkemakolam Nwachukwu*, Chidinma Chinaecherem Nwodo

Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria.

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REVIEW ON QUINOLINE ANALOGS AS POTENTIAL ANTI-HIV AGENTS

Kishore D. Deo^1*, I. J. Singhvi¹, Avinash V. Patil²

¹*Pacific Academy of Higher Education and Research University, Udaipur, India.

¹Academy of Higher Education and Research University, Udaipur, India.

²Smt. S. S. Patil College of Pharmacy, Chopda, District Jalgaon-425 107, Maharashtra, India.

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REVIEW ON IMIDAZOPYRIDINE DERIVATIVES AS POTENT REVERSIBLE INHIBITORS OF THE GASTRIC H+, K+-ATPASE

Ravindra S. Sonawane^1*, Avinash V. Patil²

¹Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India.

²Smt. S. S. Patil College of Pharmacy, Chopda, District Jalgaon-425 107, Maharashtra, India.

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ASSESSMENT OF IN VITRO ANTACID ACTIVITY OF DIFFERENT EXTRACTS OF ABRUS PRECATORIUS (L.)BY MODIFIED ARTIFICIAL STOMACH MODEL

Rupa Sengupta*¹, Dr. Maitreyi .N.Zaveri²

¹ROFEL, Shri G.M.B College of pharmacy, Vapi ,Gujarat.

²Kadi Sarva Institute of Pharmaceutical Education and Research (K.B.I.P.E.R), Sec-23, Gandhinagar, Gujarat.

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STUDY ON VARIOUS PARAMETERS FORTIFIED PANEER SPREAD

Divya Sharma, Hotam Singh Chaudhary*

Madhav Institute of Technology & Science, Gwalior – 474005, India.

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FORCED DEGRADATION STUDIES OF COMBINATION OF LEVOCETRIZINE, AMBROXOL AND MONTELEUKAST BY VALIDATED RP-HPLC METHOD

D Chaithanya Sudha Penta, Prof. Dannana Gowri Sankar

A.U.College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, A.P, India.

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PRELIMINARY QUALITATIVE SCREENING, PHYSICOCHEMICAL STANDARDIZATION AND ANTIMICROBIAL ACTIVITY OF A HERBO MINERAL SIDDHA FORMULATION GANDHAGA KARUPPU

D. Deepa Bai^1,2, Ashima Joshi^1,2, Geeta Tyagi^1,2, V. Vijaya Kumar¹, S. C. Verma*¹, M. B. Shankar¹

¹Pharmacopoeia Commission for Indian Medicine and Homoeopathy, Kamala Nehru Nagar, Ghaziabad, 201002. Uttar Pradesh, India.

²Central Council for Research in Siddha, Chennai-106.

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TOPICAL GEL FORMULATION OF DIAMINODIPHENYL SULFONE FOR ACNE VULGARIS

Venkateswaran Chidambaram Seshadri*, Packiaraj Jeyachandran Manohari, Janakiraman Kunchithapatham1, Jayanarayan Kulathingal

Department of Pharmacy, Annamalai University, Annamalai Nagar – 608002, Chidambaram, Tamil Nadu, India.

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OPHTHALMIC SOLUTION FORMULATION OF A PROSTAGLANDIN ANALOGUE FOR TREATING GLAUCOMA

Venkateswaran Chidambaram Seshadri*, Packiaraj Jeyachandran Manohari, Janakiraman Kunchithapatham, Jayanarayan Kulathingal

Department of Pharmacy, Annamalai University, Annamalai Nagar – 608002, Chidambaram, Tamil Nadu, India.

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EFFECTS OF PSYCHOEDUCATION ON ATTITUDES AND BELIEFS OF PATIENTS WITH UNIPOLAR DEPRESSION TOWARDS ANTI-DEPRESSANT THERAPY

Dhanush Pavuluri¹*, Vasireddy Krishna Sai¹, Jagadeesh Gogineni¹, Nadipena Ganesh Kumar¹, Annepu Manisha¹, Dr. Nalluri Murali Krishna², P. Sharmila Nirojini¹, Dr. Rama Rao Nadendla¹

¹Chalapathi Institute of Pharmaceutical sciences, Guntur.

²Department of Psychiatry, Guntur Medical College.

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The aim of the study was to provide psychoeducation for changing the attitudes and beliefs of patients with unipolar depression towards antidepressant treatment. The study was a prospective, comparative, randomized, interventional study conducted at psychiatry Out-patient Department in a Tertiary Care Hospital, Guntur which includes 89 patients with unipolar depression. Those patients who are receiving psychoeducation along with anti-depressant treatment are randomized into study group where as those patients only on anti-depressant therapy are grouped as control. The data was collected through Antidepressant Compliance Questionnaire at base level and after 2 months, where the study group received 3 sessions of psychoeducation with 15 days time interval between each session. Among 89 patients who participated in study, 08 could not be followed up in the study, hence dropped out. Out of 81 patients 38.2% were male and 61.7% were female. Majority of patients 44.4% were in the age group between 40 to 50 years and 87.6% of patients with 10th and below 10theducational status were found to have depression. Patient doctor relationship (Component 1 of ADCQ) had correlation of (r=0.68, p=0.0001) and have positive correlation with follow up (r=0.76, p=0.0001). The correlation is not significant at p=0.05. Correlation between positive belief on antidepressant (Component 3 of ADCQ) and follow up scores after psychoeducation (r=0.999, p=0.0001) which is significant at p=0.01. Correlation between partner's agreement (Component 4 of ADCQ) and follow up scores after psychoeducation (r=0.96, p=0.009) which is significant at p=0.05. By this we conclude that psychoeducation improves the attitudes and beliefs of the patients with unipolar depression towards antidepressants and it is main outcome is based on the patient doctor relationship where the sufficient time should be spent on the patient towards their feelings.

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The aim of the study was to provide psychoeducation for changing the attitudes and beliefs of patients with unipolar depression towards antidepressant treatment. The study was a prospective, comparative, randomized, interventional study conducted at psychiatry Out-patient Department in a Tertiary Care Hospital, Guntur which includes 89 patients with unipolar depression. Those patients who are receiving psychoeducation along with anti-depressant treatment are randomized into study group where as those patients only on anti-depressant therapy are grouped as control. The data was collected through Antidepressant Compliance Questionnaire at base level and after 2 months, where the study group received 3 sessions of psychoeducation with 15 days time interval between each session. Among 89 patients who participated in study, 08 could not be followed up in the study, hence dropped out. Out of 81 patients 38.2% were male and 61.7% were female. Majority of patients 44.4% were in the age group between 40 to 50 years and 87.6% of patients with 10th and below 10theducational status were found to have depression. Patient doctor relationship (Component 1 of ADCQ) had correlation of (r=0.68, p=0.0001) and have positive correlation with follow up (r=0.76, p=0.0001). The correlation is not significant at p=0.05. Correlation between positive belief on antidepressant (Component 3 of ADCQ) and follow up scores after psychoeducation (r=0.999, p=0.0001) which is significant at p=0.01. Correlation between partner's agreement (Component 4 of ADCQ) and follow up scores after psychoeducation (r=0.96, p=0.009) which is significant at p=0.05. By this we conclude that psychoeducation improves the attitudes and beliefs of the patients with unipolar depression towards antidepressants and it is main outcome is based on the patient doctor relationship where the sufficient time should be spent on the patient towards their feelings.

SCREENING AND DETECTION OF ALPHA AMYLASE INHIBITORS PRODUCED BY MARINE MICROORGANISMS BY MODIFIED TLC AND RPTLC METHODS

Nagamani. Bolla*¹, T. Prabhakar², G. Girija Sankar², M. Murali Krishna²

¹Viswanadha Institute of Pharmaceutical Sciences Visakhapatnam, Andhra Pradesh, India.

²Andhra University College of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh, India.

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STUDY ON ANTHELMINTIC ACTIVITY OF CURCUMA CAESIA

Vineela Chadalavada*, Soundarya Budala

SIMS College of Pharmacy, Guntur, Andhra Pradesh, India.

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IN VITRO EVALUATION OF ANTIMICROBIAL ACTIVITY OF Knema attenuata STEM BARK EXTRACT

Supriya Raja H¹*, Suku.J²

¹Department of Pharmacology, Jamia Salafiya Pharmacy College, Malappuram.

²Department of Pharmacology, College of Pharmaceutical sciences, Trivandrum.

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FORMULATION AND EVALUATION OF RABEPRAZOLE SODIUM AND DOMPERIDONE PELLETS

Department of Pharmaceutics, Malla Reddy College of Pharmacy, Hyd.

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EVALUATION OF ACTIVE COMPOUNDS OF FENUGREEK SEEDS OF WATER EXTRACT USING HPLC METHODOLOGY

Kavita Chaurasia¹, Dr. Pramod Singh^2*

¹Government Holkar Science College, Indore, M.P.

²Christian Eminent College, Indore, M.P.

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A REVIEW OF ANALYTICAL PERSPECTIVES OF LINAGLIPTIN

Shanmugakumar S.D*, Padmalatha K, Sadhu Venkateswara Rao, Veda Archana, Saipriya T, Tejaswi M1, Balakrishna M, Tejaswini, Uma Soundarya, Shymala G J

Vijaya Institute of Pharmaceutical Sciences, Enikepadu, Vijayawada, Andhra Pradesh-521108.

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A STUDY TO ASSESS AND EVALUATE THE PRESCRIBING PATTERN OF ANTI- HYPERTENSIVE DRUGS IN A TERITARY CARE TEACHING HOSPITAL

Deepa Teresa Mathew, Jubi Mathew, Pheba Thankam Moncy, Steffi John, Chaitanya Kumar T*.

Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

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PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF SHAWASAHARA DASHEMANI CHURNA

Kuldeep Kumar Soni*, Prof. K.S patel, Dr. V.K. Kori, Harisha C. R., V. J. Shukla

Department of Kaumarbhritya Pharmaceutical Chemistry Lab, I.P.G.T. & R.A, GAU.

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IMPLEMENTING OF ANALYTICAL QUALITY BY DESIGN FOR HIGH QUALITY PHARMACEUTICAL PRODUCTS

P. Abhinandana^1.2*, Ramarao Nadendla²

¹Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh-522510.

²Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh-522034.

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DRUG UTILIZATION PATTERN OF ANTIHYPERTENSIVE DRUGS IN A TERTIARY CARE TEACHING HOSPITAL IN DAVANGERE

Akhila James*¹, Sushilkumar Londhe², Dr. Jose John³

¹Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

²Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Karnataka, India.

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LIQUID CHROMATOGRAPHY MASS SPECTROMETRIC METHOD FOR QUANTIFICATION OF POTENTIAL GENOTOXIC IMPURITY 2, 6-DIAMINOPYRIDINE IN MINODRONIC ACID

Kotapati Nalini^1*2, Palnati Narmada¹, Adibhatla Kali Satya Bhujanga Rao¹, Gopal Vaidyanathan¹, Sanasi Paul Douglas²

¹Natco Pharma Limited, Natco Research Centre, B-13, Industrial Estate, Sanathnagar, Hyderabad-500018, Telangana, India.

²Department of Engineering Chemistry, Andhra University, Vishakhapatnam, Andhra Pradesh, India.

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