Welcome to Indo American Journal of Pharmaceutical Research

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

Graphical Abstract

Abstract Article Highlights Download PDF (57) Google Scholar

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

Graphical Abstract

Abstract Article Highlights Download PDF (11) Google Scholar

PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

Graphical Abstract

Abstract

Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

Article Highlights

The file does not exist in any folder.

Google Scholar

FORMULATION AND EVALUATION OF A NEW LIPOSOMAL DRUG-IN-ADHESIVE PATCH FOR TRANSDERMAL DELIVERY OF SUMATRIPTAN SUCCINATE

M. Srujan Kumar^1*, Anna Balaji²

¹Institute of Pharmaceutical and Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004.

²Pathfinder Institute of Pharmacy Education and Research, Warangal, Telangana, India-506005.

Graphical Abstract

Abstract

Abstract

The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

Article Highlights Download PDF (19) Google Scholar

Abstract

A REVIEW ON PRUNELLA VULGARIS SELF HEAL PLANT DRUG

Reshma Jain*, Sadhana Rajput

Faculty of Pharmacy, Kalabhavan Campus, The M.S.University of Baroda, Vadodara, Gujarat, India.

Graphical Abstract

Abstract Article Highlights Download PDF (20) Zenodo DOI Google Scholar

DOI Link

FORMULATION DEVELOPMENT OF ROPINIROLE HYDROCHLORIDE MICROEMULSION FOR INTRANASAL DELIVERY

Shubhrajit Mantry^1*, Anna Balaji²

¹Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer, Rajasthan- 305004, India.

²Pathfinder Institute of Pharmacy Education & Research, Beside Mamnoor Camp, Khammam Road, Warangal, India.

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Graphical Abstract

ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Graphical Abstract

PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Graphical Abstract

FORMULATION AND EVALUATION OF A NEW LIPOSOMAL DRUG-IN-ADHESIVE PATCH FOR TRANSDERMAL DELIVERY OF SUMATRIPTAN SUCCINATE

Graphical Abstract

A REVIEW ON PRUNELLA VULGARIS  SELF HEAL PLANT DRUG

Graphical Abstract

FORMULATION DEVELOPMENT OF ROPINIROLE HYDROCHLORIDE MICROEMULSION FOR INTRANASAL DELIVERY

Graphical Abstract

BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN IN RABBIT PLASMA BY RP-HPLC

Graphical Abstract

OPUNTIA FICUS  INDICA: AN ETHNOPHARMACOLOGY REVIEW

Graphical Abstract

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF METOPROLOL SUCCINATE AND CILNIDIPINE IN BULK AND PHARMACEUTICAL FORMULATION

Graphical Abstract

A RARE AND RECENT PANDEMIC VIRAL INFECTION  ZIKA DISEASE

Graphical Abstract

FORMULATION AND EVALUATION OF ACORUS CALAMUS GEL FOR TOPICAL CANDIDITIS

Graphical Abstract

EFFECT OF VITAMIN C ON HAEMATOBIOCHEMICAL PARAMETERS IN SODIUM FLUORIDE (NAF) INTOXICATED CHANNA PUNCTATUS FISHES

Graphical Abstract

FORMULATION AND EVALUATION OF TOPICAL MICROSPONGE BASED GEL OF BIFONAZOLE

Graphical Abstract

SCREENING OF TABUBEIA ROSEA DC: FOR ANTITUBERCULOSIS, ANTIBACTERIAL AND ANTIOXIDANT STUDIES; AN IN VITRO APPROACH

Graphical Abstract

INVESTIGATION OF MACROLICHENS FOR ANTIFUNGAL POTENTIALITY AGAINST PHYTOPATHOGENS

Graphical Abstract

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ANTI-MICROBIAL, ANTI-INFLAMMATORY AND ANTI-CANCER ACTIVITY OF DERIVATIVES OF ISOFLAVANOIDS

Graphical Abstract

SEARCH FOR BIOLOGICAL ACTIVE THIAZOLIDINEDIONE: A SHORT REVIEW

Graphical Abstract

IN VITRO AND IN VIVO CHARACTERIZATION OF CEFACLOR LOADED FLOATING MICROSPHERES

Graphical Abstract

A SELECTIVE AND STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ESTIMATION OF ISOMERS CONTENT IN DARUNAVIR DRUG SUBSTANCE

Graphical Abstract

IN VITRO MICROPROPAGATION, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF ORTHOSIPHON STAMINEUS BENTH

Graphical Abstract

VALIDATED HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ISOTRETINOIN AND ERYTHROMYCIN IN BULK DRUG FORM

Graphical Abstract

EVALUATION OF ANTIDIABETIC ACTIVITY OF AYU-DIA AN AYURVEDIC FORMULATION IN ALLOXAN INDUCED DIABETES MELLITUS IN RATS

Graphical Abstract

DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE ESTIMATION OF IRBESARTAN

Graphical Abstract

FORMULATION AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF A TOPICAL ANTIFUNGAL HERBAL GEL CONTAINING ETHANOLIC EXTRACT OF CASSIA ALATA LEAVES

Graphical Abstract

GASTRORETENTIVE DRUG DELIVERY SYSTEMS: A PROMISING APPROACH

Graphical Abstract

A SIMPLE UV- SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF TENELIGLIPTIN IN TABLET DOSAGE FORM

Graphical Abstract

IN VITRO MICROPROPAGATION OF ORORXYLUM INDICUM (L) KURZ AN ENDANGERED AND VALUABLE MEDICINAL FOREST TREE

Graphical Abstract

FORMULATION, EVALUATION AND ANTIBACTERIAL EFFICIENCY OF HERBAL HAND WASH

Graphical Abstract

DRUG UTILIZATION STUDY IN PEDIATRIC OUTPATIENTS AT OPD CLINICS IN SOUTH INDIAN METROPOLITAN CITY

Graphical Abstract

COMPARATIVE ANTIBACTERIAL ACTIVITY OF HYDROETHANOLIC EXTRACTS OF SOME INDIAN FLOWERS OF MEDICINAL IMPORTANCE

Graphical Abstract

A REVIEW ON PRUNELLA VULGARIS SELF HEAL PLANT DRUG

OPUNTIA FICUS INDICA: AN ETHNOPHARMACOLOGY REVIEW

A RARE AND RECENT PANDEMIC VIRAL INFECTION ZIKA DISEASE