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SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Abstract

Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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FORMULATION AND EVALUATION OF A NEW LIPOSOMAL DRUG-IN-ADHESIVE PATCH FOR TRANSDERMAL DELIVERY OF SUMATRIPTAN SUCCINATE

M. Srujan Kumar^1*, Anna Balaji²

¹Institute of Pharmaceutical and Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004.

²Pathfinder Institute of Pharmacy Education and Research, Warangal, Telangana, India-506005.

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Abstract

The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. In this study a transfersomal gel was fabricated using liposome-based nano carrier transfersome. Transfersomes as ultra-sfigurabile liposomes are prepared by rotary evaporation method with the composition of soyalecithin as lipid and propylene glycol as surfactant. Sumatriptan was selected as model drug for the treatment of migraine. Migraine is a chronic disease and the first line agents useful in treatment include NSAID’S and triptans .In recent years, most of the triptans have been designed to deliver the drug in the form of transdermal application to avoid gastrointestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The present study describes the effect of sonication on size of transfersomes for future fabrication of transfersome into Lipo-drug-In-Adhesive Patch. Transfersomes were evaluated for vesicle size; polydispersity index, zeta potential, SEM, entrapment efficiency and transfersomal gel were evaluated for In Vitro Diffusion Studies. Optimized formulation of transfersomes are further are further fabricated into patch system. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, kinetic modeling, adhesion properties and stability studies. Formulation T1 showed desirable permeation of about 99.15 at the end of 12 hours with transdermal flux of 9.288 (μg/cm2/h) and permeability coefficient 1.54 (cm/h) Patch system might follow zero-order kinetics as it was evident by correlation coefficients R2 (0.924), better fit than first order R2 (0.783) and Higuchi model R2 (0.991).

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Abstract

FORMULATION DEVELOPMENT OF ROPINIROLE HYDROCHLORIDE MICROEMULSION FOR INTRANASAL DELIVERY

Shubhrajit Mantry^1*, Anna Balaji²

¹Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer, Rajasthan- 305004, India.

²Pathfinder Institute of Pharmacy Education & Research, Beside Mamnoor Camp, Khammam Road, Warangal, India.

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

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ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

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FORMULATION AND EVALUATION OF A NEW LIPOSOMAL DRUG-IN-ADHESIVE PATCH FOR TRANSDERMAL DELIVERY OF SUMATRIPTAN SUCCINATE

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FORMULATION DEVELOPMENT OF ROPINIROLE HYDROCHLORIDE MICROEMULSION FOR INTRANASAL DELIVERY

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BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN IN RABBIT PLASMA BY RP-HPLC

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DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE DELIVERY SYSTEM OF LOSARTAN POTASSIUM

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A NEW METHOD DEVELOPMENT AND VALIDATION OF DUAL WAVELENGTH UV SPECTRO- PHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF METAXOLONE AND DICLOFENAC POTASSIUM IN COMBINED DOSAGE FORM

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PHYTOCHEMICAL STUDIES AND ANTIOXIDANT ACTIVITY OF BACOPA MONNIERI PLANT LEAVES PROTEINS

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REDISCOVERY OF IGF-1R TARGETED INHIBITORS FROM AN APPROVED DRUGS DATABASE THROUGH RECEPTOR-BASED PHARMACOPHORE MODELLING AND DOCKING

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SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF POORLY WATER SOLUBLE DRUG BY USING UREA AS HYDROTROPIC AGENT

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A OVERVIEW ON EPILEPSY AND ANTI-EPILEPTIC THERAPY

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MICROEMULSION BASED GEL DRUG DELIVERY SYSTEM

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HERB-DRUG INTERACTION BETWEEN ETHANOLIC EXTRACT OF ALOE VERA WITH GLIPIZIDE IN STREPTOZOTACIN INDUCED DIABETIC RATS

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EVALUATION OF IN VITRO ANTI-INFLAMMATORY AND IN VIVO ANTIARTHRITIC ACTIVITY OF CLINACANTHUS SIAMENSIS

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FORMULATION OF DOXORUBICIN LOADED SOLID LIPID NANOPARTICLES IN ORDER TO IMPROVE ORAL BIOAVAILABILITY

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URSANES FROM SALVIA SPECIES

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COMPREHENSIVE ADVERSE DRUG REACTION MONITORING IN DERMATOLOGY DEPARTMENT

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CHALCONES -VERSATILE AND EMERGING LEAD MOLECULES: SYNTHESIS, STRUCTURE DIVERSITY: A REVIEW

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SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES USING ALLIUM CEPA AND ITS ANTI-INFLAMMATORY ACTIVITY AGAINST HUMAN BLOOD CELLS

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STABILITY-INDICATING STRESS DEGRADATION STUDIES OF RILPIVIRINE HYDROCHLORIDE USING UV SPECTROPHOTOMETRIC METHOD

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PRODUCTION AND OPTIMIZATION OF PECTINASE BY BACILLUS SP. ISOLATED FROM VEGETABLE WASTE SOIL

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FORMULATION AND EVALUATION OF OXYBUTYNIN CHLORIDE EXTENDED RELEASE MATRIX TABLETS

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RED ALGAE DIVERSITY FROM THOOTHUKUDI AND ITS THERAPEUTIC POTENTIALS: A SEARCH

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EFFECT OF SUPERDISINTEGRANTS ON IN-VITRO DRUG RELEASE OF ACECLOFENAC AND PARACETAMOL TABLET

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FORMULATION AND EVALUATION OF CONTROLLED RELEASE GASTRO-RETENTIVE MUCO-ADHESIVE MICROSPHERES FOR DILTIAZEM HYDROCHLORIDE

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ENHANCEMENT OF SOLUBILITY BY USING HYDROXYPROPYL B-CYCLODEXTRINS OF LIPOPHILIC DRUG AND FORMULATION OF FAST DISSOLVING TABLET

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TO INVESTIGATE ANTI-ARTHRITIC ACTIVITY OF PSORALEA CORYLIFOLEA EXTRACT AND CLOZAPINE IN RATS

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FORMULATION DEVELOPMENT OF RIVAROXABAN LIPID SOLID DISPERSION USING DIFFERENT TECHNIQUES FOR THE DISSOLUTION ENHANCEMENT

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HEPATO AND NEPHRO  PROTECTIVE EFFECT OF TINOSPORA CORDIFOLIA AGAINST SODIUM NITRITE  INDUCED OXIDATIVE STRESS

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URSANES FROM SALVIA SPECIES

HEPATO AND NEPHRO PROTECTIVE EFFECT OF TINOSPORA CORDIFOLIA AGAINST SODIUM NITRITE INDUCED OXIDATIVE STRESS