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SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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ONE POT SYNTHESIS OF 1, 8- DIOXO -OCTAHYDROXANTHENES IN AQUASE PHASE USING ? - CYCLODEXTRIN AS AN EFFICIENT AND GREEN CATALYST

Shankar P Hangirgekar*, Vijay V Kumbhar,Navanand B Wadwale
School of Chemical Sciences, S.R.T.M.University, Nanded-431606, Maharashtra India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Abstract

Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN IN RABBIT PLASMA BY RP-HPLC

Sandhya Pamu*^1,2, Subrahmanyam C V S², Rao Patnaik K S K¹

¹Department of Pharmacy,University College of Technology, Osmania University, Hyderabad 500 007, India.

²Gokaraju Rangaraju College of Pharmacy College, Bachupally, Hyderabad 500090, Telangana State, India.

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A COMPLETE PROFILE ON CYCAS BEDDOMEI - TRADITIONAL USES, PHARMACOLOGICAL ACTIVITES AND PHYTOCONSTITUENTS

Baggiya Selvi David¹, Raja Sundararajan²

¹Department of Pharmacognosy, Karnataka College of Pharmacy, Bangalore-560064, Karnataka-State, India.

²GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-500045, Andhra Pradesh, India.

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PRESCRIBING PATTERN IN PREGNANT WOMEN IN A TERTIARY CARE TEACHING HOSPITAL

Marla Kowndinya Kumar^1*, Randeep Raj V C¹, L. Ekaja Reddy¹, Dr. MD. Dhana Raju²

¹Department of Pharmacy Practice, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.

²Principal, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.

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SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF GATIFLOXACIN AND DEXAMETHASONE IN THEIR BINARY MIXTURE

Sawsan A. Abdel-Razeq¹, Manal M. Fouad¹, Manal K. Darwish², Hala E. Zaazaa³, Zeinab A. Nasr^*1

¹Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

²Pharmaceutics and Industrial Pharmay Department, Faculty of Pharmacy, Al-Azhar University,Cairo, Egypt.

³Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

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INCIDENCES OF WHITE FECES SYNDROME (WFS) IN FARM-REARED SHRIMP, LITOPENAEUS VANNAMEI, ANDHRA PRADESH

S. A. Mastan

P V S Laboratories Limited, Aqua Health Care Division, Kohinoor Apartments, Kalanagar, Benz Circle, Vijayawada-520 010 Andhra Pradesh.

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DESIGN AND EVALUATION OF TRANSDERMAL PATCH OF FELODIPINE

Sheetal Chauhan^1*, Dr. Uday B. Bolmal¹, Dr. Panchaxari Mallappa Dandagi¹, Dr. Ajit Singh²

¹Department of Pharmaceutics, KLEU’s College of Pharmacy, JNMC Campus, Nehru Nagar, Belgaum - 590 010, India.

²Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka- 576104, India.

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POTENTIAL ROLE OF VITAMIN-D IN DERMATOLOGICAL CONDITIONS

Dr K. Narotham Reddy, M. Venkata Subbaiah, R. Siddarama, H. Shree Hari

¹Assistant Professor, Department of Dermatology, Venereology, Leprosy, RIMS, Kadapa, India.

²Assistant Professor, P Rami Reddy Memorial College of Pharmacy, Kadapa, India.

³Department of Clinical Pharmacy, Rajiv Gandhi Institute of Medical Sciences, PRRMCP, Kadapa, India.

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ONE-POT SYNTHESIS OF HANTZSCH ESTERS AND POLYHYDROQUINOLINES CATALYZED BY LITHIUM BROMIDE

K. R.Gopinath¹, K. J. Rajendraprasad², B. M. Nagabhushana³, Manjula Krishnappa^4*

¹Research and Development Center, Bharathiar University, Coimbatore, Tamilnadu-641046, India.

²Department of Chemistry, Bharathiar University, Coimbatore, Tamilnadu-641046, India.

³ Department of Chemistry, M.S. Ramaiah Institute of Technology, Bangalore -560 054, India.

⁴Department of Chemistry, SSMRV College, Chemistry Research Center, 4th T-block, Jayanagar, Bangalor- 560 041, India.

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ELUCIDATING THE ROLE OF CARDIAC BIOMARKERS IN CHRONIC KIDNEY DISEASE

Raju DSSK¹, Kiranmayi Patnala^2*

¹Assistant Professor, Department of Biochemistry, MIMS, Nellimarla, Vizianagara.

²Assistant Professor, Department of Biotechnology, GITAM University, Visakhapatnam, India.

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IDENTIFYING EXPRESSION PROFILE OF MICRO RNA IN ARTHRITIS TO SPOT NOVEL BIOMARKERS

Syed Zafer Ali, Ruqiya Sultana, Fahmeena Fatima, Hussaini Begum, Mohd Khader, Syed Vazeer.

Dept. of Pharmacology, Deccan School of Pharmacy, Hyderabad.

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FORMULATION AND EVALUATION OF BILAYER TABLET OF FAMOTIDINE WITH ANTACID LAYER

Kamal Kumar Bhatt*, shivani kala, Divya juyal

Himalayan Institute of Pharmacy & Research Rajawala, Dehradun (Uttarakhand).

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SIMULTANEOUS ESTIMATION OF PARACETAMOL, IBUPROFEN AND FAMOTIDINE BY USING RP-HPLC METHOD

Allabasha Mumtaz, Mrs. Iffath Rizwana

Department of Pharmaceutical Analysis & QA, Deccan School of Pharmacy (Affiliated to Osmania University),Nampally,Hyderabad-500001.

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STUDY ON PRESCRIBING PATTERNS OF ANTI HYPERTENSIVES IN OUTPATIENTS

Lakshmi I, Bhargavi. D, Venkateswaramurthy. N*, SambathKumar. R

Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam,Tamilnadu-638183, India.

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Abstract

Background: Hypertension is one of the leading cause among the most of the cardiovascular diseases worldwide. Many clinical trials were conducted and number of guidelines was published regarding hypertension treatment. Whereas the prescribing patterns of these medicines doesn’t comply with the standard guidelines given by JNC-8. Many factors plays a key role during prescribing of medicines such as patient age, sex, occupation and blood pressure range which is major factor to be considered initially. So, all these factors and recommended guidelines should be linked up to prescribe the appropriate medicine to the patient according to his condition. If these factors were not taken into considerations before treatment then it remains unsatisfactory. Objective: The purpose of the study was to evaluate the prescribing patterns of antihypertensives in outpatients. And to evaluate whether the provided treatment comply with guidelines and is it satisfactory or not. Methods: It is an Observational, Prospective, Non-Interventional study. The study was conducted in outpatient department of a tertiary care hospital, Erode district. It was conducted for a period of six months and the prescriptions were collected during March-2014 to August-2014. The age group taken under study was 31-90years and size of the study population was 250 hypertensive patients. Results: Our research team found that commonly prescribed antihypertensives were monotherapy (74.8%) followed by two drug combination therapy (21.2%) whereas least prescribed was three drug combination therapy (04%). Under monotherapy calcium channel blockers (15.2%) were highly prescribed followed by β-blockers (14%) and loop diuretics (12%). Combination therapy consist of two antihypertensives as a co-formulation and most prescribed --blockers + loop diuretics (4.4%). Under three drug combination therapy most prescribed class of antihypertensives were ß-blockers + angiotensin converting enzyme inhibitors + calcium channel blockers and ß-blockers + calcium channel blockers + loop diuretics comprises of (1.2%) followed by ß-blockers + calcium channel blockers + α1- blockers and ß-blockers + angiotensin converting enzyme inhibitors + aldosterone antagonistscomprises of (0.8%) of total therapy. Conclusion: The study reported that overall highly prescribed class of antihypertensives were β-blockers (38.4%) followed by calcium channel blockers (37.6%). aldosterone antagonist and three drug combination therapy was under prescribed in this study. Hereby approaching to the final conclusion the prescribing pattern doesn’t comply with the provided JNC-8guidelines.