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SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

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PHYTONUTRIENT COMPOSITION AND ANTIOXIDANT ACTIVITY OF PROCESSED FLAXSEED

Dharshini¹, Dr.S.Sumayaa², Dr.T.Thirunalasundari ³

¹Research Scholar, Department of Food Science and Nutrition, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

²Head of the Department, Department of Biotechnology, Bharathidasan University, Tiruchirappali, Tamil Nadu, India.

³Principal, Thassim Beevi Abdul Kader College for Women, Kilakarai, Tamil Nadu, India.

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Flax is a nutraceutical with many nutritional benefits. Aside from the vitamins, minerals, fiber and protein it contains some primary and secondary metabolites. Flaxseed is a good source of omega-3 fatty acids. Through its high concentration of alpha-linolenic acid, flax provides more omega-3 fatty acids than any other grain. (57% of its fatty acids are omega-3s.) As the health revolution continues to evolve, look for it to be added to more and more processed foods to attain the health smart claim. Flaxseed (FS), a whole grain used as a nutritional supplement, has gained popularity because it is a rich source of natural antioxidants. Dietary intake of polyphenols has been associated to reduce risk of chronic diseases, such as heart disease, stress induced diabetes and cancer. This is probably due to their antioxidant properties. Many phenolic compounds have been detected in Flaxseed. Hence with the objectives to analyze the phytonutrient composition, assess the non-antioxidant enzymes vitamin A, E and C and find the antioxidant activity of processed flaxseed the study was carried out. The flaxseed was subjected to various methods of food processing like roasting, pressure cooking and soaking. The processed flaxseed was further analysed the primary and secondary metabolites and their antioxidants activity. This study does not show much variation in primary and secondary metabolites between the raw and roasted seeds. The acceptance and palatability was high in the case of roasted soybean and flaxseed because of their nutrients nutty flavour, colour and texture than the unprocessed seeds. Non- antioxidant enzymes, vitamin A, vitamin E and vitamin C content was high in both soaked and roasted flaxseed. Antioxidant activity was high in roasted and soaked flaxseed. Thus the presence of these phytonutrient and antioxidant activity of processed namely roasted and soaked flaxseeds indicates that, it has a potential of being used in formulations prepared for food consumption. Flaxseed could also be a remedy for the major killer diseases like cancer, diabetes and cardiovascular diseases.

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Comparative Evaluation of Antidaibetic Activities of Miglitol alone and combination with Salacia Species in patients of Type II Diabetes Mellitus

A D Landge^1*, C R Pawar², S R Chaudhari¹, P R Gade³

¹Amrutvahini College of Pharmacy Sangamner 422605, Dist Amhednagar Maharashtra India

²Govt. Polytechnic College Dept of Pharmacy Jalgaon 425001 Maharashtra.

³Maharashtra Institute of Medical Science and Research Latur 413512 Maharashtra.

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COMPARATIVE EVALUATION OF ANTIDAIBETIC ACTIVITIES IN PATIENTS OF TYPE II DIABETES MELLITUS TREATED WITH ACARBOSE ALONE AND IN COMBINATION WITH SALACIA SPECIES

A D Landge¹*, C R Pawar², S R Chaudhari¹, P R Gade³

¹Amrutvahini College of Pharmacy Sangamner 422605, Dist Amhednagar Maharashtra India.

² Govt. Polytechnic College Dept of Pharmacy Jalgaon 425001 Maharashtra.

³Maharashtra Institute of Medical Science and Research Latur 413512 Maharashtra.

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SYNTHESIS, CHARACTERIZATION AND IN VITRO BIOLOGICAL EVALUATION OF 4-[(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)AMINO]-2-METHYLIDENE-4-OXOBUTANOIC ACID

Prakash S. Nayak¹, Badiadka Narayana¹* and Balladka Kunhanna Sarojini²

¹Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India.

²Industrial Chemistry- Division, Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India.

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PHOTOCATALYTIC DEGRADATION OF PROCION BRIGHT TURQUOISE MX-G DYE USING BIOGENIC SILVER NANOPARTICLES (AGNPS) SYNTHESIZED FROM ALPINIA CALCARTA ROSC

Sachindri Rana¹, K. Ghanapriya², K. Priadharsini², K. Rajagopal¹and P. T. Kalaichelvan²

¹ Department of Biotechnology, Vels University, Pallavaram, Chennai-600117, Tamil Nadu, India.

² Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai-600025, Tamil Nadu, India.

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STABILITY STUDIES OF RIBAVIRIN SYRUP

Dhanyakumar Chougule*, Nilofar Naikwade

Appasaheb Birnale College of Pharmacy, Sangli

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DEVELOPMETN AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE IN TABLET DOSAGE FORM

Sriveena G S¹, Chinna lalaiah Runja², Dr JVC Sharma², Soumya G², Sandeep M²

¹Department of pharmaceutical analysis and quality assurance, Joginpally BR pharmacy college, Yenkapally, Moinabad mandal P.O. Himayathnagar, R.R. District, Hyderabad-500075, Andhra Pradesh, India.

²Joginpally BR pharmacy college, Hyderabad-500075, Andhra Pradesh, India.

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PREPARATION AND BIOPHARMACEUTICAL EVALUATION OF PIROXICAM LIQUISOLID SYSTEMS

Srinivas Lankalapalli*, V S Vinai Kumar Tenneti, Ramya P, Manasa P

GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam, Andhra Pradesh State, India.

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SYNTHESIS AND CHARACTERIZATION OF PH-SENSITIVE POLY (METHACRYLIC ACID)-GRAFT-KARAYA GUM AS A MATRIX FOR CONTROLLED RELEASE TABLETS

*Momin Maruf¹, Maria Saifee¹, J N Sangshetti², Zahid Zaheer³

¹Department of Pharmaceutics, Y B Chavan College Of Pharmacy, Aurangabad, Maharashtra, India, 431001,

²Department of Pharmaceutical Chemistry, Y B Chavan College Of Pharmacy, Aurangabad, Maharashtra, India, 431001

³Department of Quality Assurance, Y B Chavan College Of Pharmacy, Aurangabad, Maharashtra, India, 431001

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CYANOBACTERIA: NATURAL OCCURRING UNTAPPED VALUABLE RESOURCE

Maheep Kumar

Department of Botany,Guru Ghasidas Vishwavidyalaya, Bilaspur-495009, India.

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TRADITIONAL PHYTO-THERAPY WITH HERBAL COMPOSITIONS USED BY FOLK-PRACTITIONERS OF TRIPURA (NORTH-EAST) FOR TREATMENT OF VARIOUS DISEASES

Prashanta Kumar Deb¹, Tejendra Bhakta², Tarun Kanti Ghosh², Rajat Ghosh^1*

¹Department of Pharmacy, Tripura University (A Central University), Suryamaninagar-799022, Tripura (W), India.

²Regional Institute of Pharmaceutical Science & Technology, Abhoynagar, Agartala–799005, Tripura (W), India.

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PRODUCTION OF BACTERIOCIN BY LACTOCOCCUS GARVIEAE AND INFLUENCE OF VARIOUS SUPPLEMENTS ON ITS ANTIMICROBIAL ACTIVITY

Suneel Dodamani^,Basappa Kaliwal*

Department of Biotechnology and Microbiology, Karnatak University, Dharwad, Karnataka, India.

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The aim of this study is to evaluate the production and antimicrobial potential of bacteriocins released by Lactococcus garvieae. Bacteriocins are extracellular in nature having inhibitory activity against other bacteria. The Lactococcus garvieae was isolated from cow’s milk which produces bacteriocins was evaluated by using different media such as MRS (Mann Rogasa Sharpe), M17, Soybean casein digest broth and Brain Heart Infusion (BHI) broth. Further, the effect of various supplements on antimicrobial activity of bacteriocins against gram-positive bacteria viz., Staphylococcus aureus, Bacillus subtilis and Bacillus cereus and gram-negative bacteria viz., Pseudomonas aeruginosa and Escherichia coli was also evaluated. The results indicate that Lactococcus garvieae yielded high level of bacteriocins 14363.6 AU/ml in M17 medium, where as 11064.5 AU/ml in Soyabean casein digest, 12119.3 AU/ml in BHI, and 13219.0 AU/ml in MRS media at 48 h of incubation. Addition of supplements viz., tween 20, tween 80, amylase, proteinase K and asparginase reduced the antimicrobial activity of bacteriocins. Whereas Urea, EDTA and NaCl have increased antimicrobial activity of bacteriocins. It is noticed that incubation period of 40, 50 and 60 h, at temperature of 30°C, 40 °C and pH of 6 was found to be an ideal for higher bacteriocins activity. In conclusion, the M17 medium was found to be best for bacteriocins production and the supplements such as Urea, EDTA, and NaCl were found to enhance the antimicrobial activity of bacteriocins. Whereas, pH of 6 was found to be best for bacteriocins production. Therefore, these results are encouraging since the inclination nowadays is to produce large quantities of bacteriocins/probiotics/Antimicrobial peptides (AMPs) which have immense clinical usage in manufacture of alternative types of antibiotics and in various drug preparations.

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FORMULATION BY 23 FACTORIAL DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF METOPROLOL SUCCINATE

G. Saravanan*¹, Sarath Chandiran Irisappan ², K.N. Jayaveera³

^1*Assistant Professor, Dr. Samuel George Institute of Pharmaceutical Sciences, Markapur-523316, Andhra Pradesh, India

²Professor & Principal, Gokula Krishna College of Pharmacy, Sullurpet-524121, Nellore dist, A.P, India.

³ Prof & Head, Department of Chemistry, JNTU Anantapur, Anantapuram – 515 002, Andhra Pradesh, India

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DESIGN AND DEVELOPMENT OF SOLID LIPID NANOPARTICLES OF THIOCOLCHICOSIDE BY BOX-BEHNKEN DESIGN

Mousumi Kar, Priyanka G.P. and Dinesh Kumar Jain

College of Pharmacy, IPS Academy, Indore, Madhya Pradesh

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Formulation and Evaluation of Clotrimazole Hydrotropic Starch Gel

Sayyed Nazim* , Siraj Shaikh , Tarique khan ,Shaikh Sabnam

Department Of Pharmaceutics, Ali Allana College Of Pharmacy Akkalkuwa. Dist- Nandurbar , Maharashtra,India.

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DEVELOPMENT AND VALIDATION OF RP -HPLC METHOD FOR THE DETERMINATION OF NIFLUMIC ACID IN HUMAN PLASMA

Jyothirmai ¹, Satyadev TNVSS², Tata Santosh³, B. Syama Sundar^* ⁴

¹. Jyothirmai, Research scholar, Dept of Chemistry, Acharya Nagarjuna University

^2. Lecturer, P B Siddhartha College of Arts & Science,Vijayawada

³. Corpuscle Research Solutions, Visakhapatnam.

⁴. Vice - Chancellor, Yogi Vemana University, Kadapa.

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HISTOPATHOLOGICAL MANIFESTATIONS IN COMMERCIALLY IMPORTANT FISH, CLARIAS BATRACHUS(L.) FOUND INFECTED WITH SAPROLEGNIA DICLINA.

Rekha Chauhan, Ashiq Hussian Beigh and Magid Hassan Bhat

Department of zoology and applied aquaculture, Barkatullah University, Bhopal.

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PHYTOCHEMICAL SCREENING AND IN VITRO ANTIBACTERIAL ACTIVITY OF CAMELLIA SINENSIS

JelamVazir*¹, Priyal Inamdar¹,Sharav Desai²,.Dhara Patel¹,Dhananjay Meshram¹

¹Department of Quality Assurance, Pioneer Pharmacy Degree College, Vadodara, Gujarat, India.

²Department of Pharmaceutical Microbiology and Biotechnology, Pioneer Pharmacy Degree College, Vadodara, Gujarat, India

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SCREENING OF STRESS RELATED FACTORS IN RURAL ADOLESCENT POPULATION

Praveen. D*, Ranadheer Chowdary.P, J. Divya Maria, Gthanmayi ,Satyanarayanan.G, S.Yeswanthi, G.Poojitha

School of Pharmaceutical Sciences, Vels University.

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SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND GUIAFENESIN IN PHARMACEUTICAL DOSAGE FORM BY VALIDATED RP-HPLC METHOD

Satyanarayana M.V^1*, Satyadev TNVSS², Anuradha V³

1. Dept of Freshman Engineering, PVP Siddhartha Institute of Technology, Kanuru, Vijayawadsa

2 .Lecturer, PG Department of Chemistry, P B Siddhartha College of Arts & Science,Vijayawada

3. Professor, Dept of Chemistry, Vignan PG College, Pedapalakaluru, Guntur, India

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ANTILEPTOSPIRAL POTENTIAL OF MARINE ACTINOMYCETES (MSU5) AGAINST Leptospira interrogans SEROVAR AUTUMNALIS

J.Thirumalairaj¹, K. Sivasankari², K. Natarajaseenivasan² and R. Balagurunathan^1*

¹ Actinobacterial Research Laboratory, Department of Microbiology, Periyar University Salem - 11

² Medical Microbiology Laboratory, Department of Microbiology, Bharathidasan University Tiruchirapalli - 24

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INFLUENCE OF DISOPYRAMIDE ON THE PHARMACODYNAMICS AND PHARMACOKINETICS OF GLICLAZIDE IN RABBITS

Abedulla Khan K*¹, Satyanarayana S ², Eswar Kumar K ³ and Anupama K ¹

¹ Sultan-ul-uloom College of pharmacy, Banjara hills, Hyderabad-34, A.P

² Avanti Institute of Pharmaceutical Sciences, cherukapally (V), Vizianagaram (Dt), A.P.

³ A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P.

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PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTHELMINTIC ACTIVITY OF LEUCAS INDICA VAR. NAGALAPURAMIANA

KOTHA ARUN KUMAR*, VELETI KOWMUDI, SREEKANTH.K, S.SHASHIDHAR REDDY

Pharmaceutical Quality Assurance Group, Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri ShivarathreeshwaraNagara, Mysore-570015, Karnataka, India.

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QUALITATIVE PHYTOCHEMICAL SCREENING & ACUTE TOXICITY STUDY AND LD50 DETERMINATION OF DATURA METEL.

Sarkar S*¹, Das S², Ghosh A³.

¹Pharmaceutical chemistry lab, Bengal College of Pharmaceutical Sciences & Research, B.R.B Basu Sarani, Bidhannagar

²Pharmacology lab, Bengal College of Pharmaceutical Sciences & Research, B.R.B Basu Sarani, Bidhannagar

³Pharmaceutics lab.Bengal College of Pharmaceutical Sciences & Research, B.R.B Basu Sarani, Bidhannagar, Durgapur-713212,West Bengal,India.

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HERBAL PLANTS IN PHOTO PROTECTION AND SUN SCREENING ACTION: AN OVERVIEW

Snehal.S Kulkarni^*, Rasika.D Bhalke, Vishal.V Pande, Prakash.N Kendre

Department of Pharmaceutics Sanjivani College of Pharmaceutical Education and research Kopargaon, Sahjanandnagar (M.S) India

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UNANI CONCEPT AND MANAGEMENT OF WAJA-UL-MAFASIL (ARTHRITIS) WITH SPECIAL REFERENCE TO HIJAMAH (CUPPING THERAPY)

Sheikh Haneef Mohammad, MD¹; Fasihuzzaman, MD²; Azhar Jabeen, MD³; M. A. Siddiqui, MD⁴

¹Lecturer, Department of Moalijat (Medicine), A & U Tibbia College, Karol Bagh, New Delhi

²Associate Prof, Department of Moalijat (Medicine), Jamia Hamdard, Hamdard Nagar, New Delhi-110062

³Azhar Jabeen MD (Unani), Asst. Prof, Department of Moalijat (Medicine), Jamia Hamdard, Hamdard Nagar, New Delhi-110062

⁴Head, Department of Moalijat (Medicine), Jamia Hamdard, Hamdard Nagar, New Delhi-110062

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Abstract*

Arthritis is described in Unani system of medicine under a broad term Waja-ul-Mafasil which encompasses entire joint disorders like inflammatory, non-inflammatory, infectious, metabolic and other musculoskeletal disorders. With the advent of science and technology, modern classification has separated these individually according to their etiopathology. On deep insight of Unani literature, arthritis can be correlated with various types of Waja-ul-Mafasil in resemblance to the predisposing factors, aggravating factors and pattern of joint involvement. Unani system of Medicine is based upon Hippocrates’s theory of four humours (Akhlat). According to Unani concept, the pathological changes in the joints are caused mainly by derangement of humoural temperament and accumulation of Mawad-e-Fasida (Morbid material) in the joint spaces. The derangement may be simple, causing only functional disturbance of articular surfaces, or it may be compound in which organic disturbance and quantitative changes take place in the joints. The aim of treatment for patient with Waja-ul-Mafasil is to reduce morbidity and disability. The principle of treatment aims at restoring the normal temperament, and correcting the imbalance in the Khilt (humour) through Imala (Diversion of morbid material) and Istifraagh (Evacuation of morbid material). Hijamah (Cupping therapy) is a regimenal mode of treatment recommended by eminent Unani physicians for the management of Waja-ul-Mafasil, serve the both purposes. Based on modern parameters, Hijamah (Cupping therapy) has been proven beneficial in the improvement of various signs and symptoms of the arthritis. As an adjuvant therapy Hijamah provides significant improvement in pain and has a marked effect in improving the quality of life. It has immunomodulatory effect that could be used as monitoring tool for disease activity and prognosis.

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PHYTOCHEMICAL INVESTIGATION OF ETHNO MEDICINAL PROSOPIS SPICIGERA LEAVES

Jameel Ahmed*, Vishvnath B. Bharkad¹ and Namdev Y. Gond²

Department of Pharmacognosy,Indira College of Pharmacy,Vishnupuri, Nanded-431606(M.S.) India.

Department of Pharmacognosy,CRPS, Nanded Pharmacy College,Shyam nagar, Nanded-431605(M.S.) India.

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EVALUATION OF FLOATING DRUG DELIVERY SYSTEMS OF FAMOTIDINE: STUDY OF EFFERVESCENT GRANULES AND FLOATING BEADS

Bhargavi Chinta¹, Madhavi Nannapaneni²*, Tata Santosh³

¹Lecturer, Dept of Chemistry, Andhra Loyola College, Vijayawada, A.P, India

²H.O.D, PG Department of Chemistry, J.K.C college, Guntur, A.P.

³Corpuscle Research Solutions, Visakhapatnam, A.P.

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SYNTHESIS, CHARACTERIZATION, AND IN-VITRO ANTI CANCER ACTIVITY OF SOME NEW 1,3,4 THIADIAZOLES ON (HT-29) COLORECTAL CELL LINES

Suddhasatwa Banerjee, Thonda V.S.S Swaroop, Ibel.C.Fredy, Apoorva Singh, M. Sowmya lakshmi, Dr. S. Mohan, Dr. J. Saravanan.

PESCP, Department of Pharmaceutical Chemistry PES College of Pharmacy Bangalore-560050

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